Allergy to latex in spina bifida: A multivariate study of associated factors in 100 consecutive patients☆, ☆☆, ★

Estornell, F.; Mazón, Ángel; Reig, Celia; Nieto, Antonio; García-Ibarra, F

doi:10.1016/s0091-6749(96)70082-9

Cited by 102 publications

(54 citation statements)

References 26 publications

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“…Demographic data, such as age (37,40) and gender (6), contact with latex products, including number of surgical interventions (7,29,30,33,37,(39)(40)(41)(42)(43) performing cystourethrograms and bladder catheterization (37), existence of hydrocephalus with ventriculoperitoneal shunt (37,41,49), atopy (7,29,30,37,40,41), fruit sensitization (7) and high levels of total IgE (7, 37) have been identified as risk factors. Some of these characteristics are related to each other.…”

Section: Discussionmentioning

confidence: 99%

“…There are few studies performing logistic regression analysis, allowing the identification of significant and independent risk factors (7,37,40). The importance of a high number of surgeries in latex sensitization was documented in most studies (7,29,30,33,37,(39)(40)(41)(42)(43), although the value from which there is a risk is not usually mentioned. Bernardini et al (7), in a population of 59 patients with spina bifida, identified 5 or more surgical interventions as a risk factor.…”

Section: Discussionmentioning

confidence: 99%

“…Several published studies found prevalences between 4.3 % and 73.3 % (table I) (5)(6)(7)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). The variability of results can be related with differences in the methodology, namely variables related with the population in study (dimension and age group) or the diagnostic method (SPT and/or serum IgE determination, absence of allergenic extract standardization and different methodology of SPT).…”

Section: Introductionmentioning

confidence: 99%

“…The high prevalence of sensitization seems to be a result, mainly, of early (33,34,(39)(40)(41) and frequent contact with latex products (7,29,30,33,37,(39)(40)(41)(42)(43). The exposure begins, frequently, in the first day of life, with myelomeningocele surgical closure, and continues during several surgical procedures to correct neurologic, urologic and orthopedic congenital malformations.…”

Section: Introductionmentioning

confidence: 99%

“…The predisposition to produce high levels of specific IgE in response to allergenic exposure, related to a high atopic risk, has been a factor frequently associated to latex sensitization in this population (7,29,30,37,40,41).…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for latex sensitization in children with spina bifida

Pires

Morais‐Almeida

Gáspár

et al. 2002

Allergologia et Immunopathologia

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SUMMARYBackground: Children with spina bifida represent the major risk group for latex sensitization.Purpose: To determine the prevalence of latex sensitization in these children and to identify risk factors.Material and methods: We studied 57 patients with spina bifida. The mean age was 5.6 years and the male/female ratio was 0.8/1. In all patients a questionnaire, skin prick test (SPT) with latex (UCBStallergènes, Lofarma and ALK-Abelló), common aeroallergens and fruits (UCB-Stallergènes) and serum determination of total IgE (AlaSTAT) were performed.Results: The prevalence of latex sensitization was 30 %; only two sensitized children (12 %) had symptoms after exposure. Risk factors for latex sensitization were age Ն 5 years (p = 0.008; OR = 6.0; 95 % CI = 1.7-22.1), having at least four previous surgical interventions (p < 0.0001; OR = 18.5; 95 % CI = 3.6-94.8), having undergone surgery in the first 3 months of life (p = 0.008; OR = 5.4; 95 % CI = 0.7-29.2) and total serum IgE Ն 44 IU/ml (p = 0.03; OR = 3.8; 95 %CI = 1.1-13.1). Multiple logistic regression analysis showed that only a history of four or more surgical interventions (p < 0.0001; OR = 26.3; 95 %CI = 2.9-234.2) and total serum IgE Ն 44 IU/ml (p = 0.02; OR = 8.6; 95 % CI = 1.4-53.4) were independently associated with latex sensitization. Sex, family and personal allergic history, hydrocephalus with ventriculoperitoneal shunt, cystourethrograms, intermittent bladder catheterization and atopy were not related to latex sensitization. Conclusions:In children with spina bifida, significant and independent risk factors identified for latex sensitization were multiple interventions and higher levels of total serum IgE. A prospective study will clarify the clinical evolution of assymptomatic children sensitized to latex.

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