Allergy to lansoprazole: study of cross‐reactivity among proton‐pump inhibitors

Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors

“…We have found only a previous case report of hypersensitivity to lansoprazole and a possible cross-reactivity with rabeprazole, on the evidence of a positive intradermal test, although it was performed from the commercially available formulation. 6 The clinical features of the reactions to PPIs described in most reports suggest an IgE-mediated mechanism, as demonstrated by positive skin test results, 4,6-10 including our case.…”

“…Lansoprazole has been reported as a cause of few hypersensitivity reactions. [1][2][3][4][5][6][7] We report here a case of reproducible allergy to lansoprazole with cross-reactivity to rabeprazole, but tolerance to omeprazole and pantoprazole.…”

Hypersensitivity to proton pump inhibitors: Lansoprazole-induced Kounis syndrome

“…A recent literature review [14] has shown that only the newest proton pump inhibitors rabeprazol and esomeprazol are free, so far, of such reactions. Crossreactivity between the various brands has been also reported [12].…”

“…Few proton pump inhibitors used in everyday practice have been incriminated in rare occasions to induce hypersensitivity reactions. The older preparations omeprazole [6][7][8][9][10], lansoprazole [11][12][13][14] and pantoprazole [15][16][17] have all been, although rarely, associated with hypersensitivity reactions. A recent literature review [14] has shown that only the newest proton pump inhibitors rabeprazol and esomeprazol are free, so far, of such reactions.…”

Anaphylactic reaction to omeprazole

“…Although hypersensitivity reactions are rare, several anaphylactic reactions have been reported [2][3][4][5] .Some reports describe the presence of cross-reactivity between different members of the group, although no definite pattern has emerged [6][7][8][9] . We present a case of omeprazole induced anaphylactic reaction which was managed uneventfully.…”