Allergy to insulin, liver, pituitary, pancreas, estrogens, enzymes, and similar substances

Harten, Max; Walzer, Matthew

doi:10.1016/s0021-8707(40)90396-3

Cited by 20 publications

(2 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 ' 18 We found the mean time of onset was 13 days from the first injection. 17 ' 18 We found the mean time of onset was 13 days from the first injection.…”

Section: Time Of Onset and Durationmentioning

confidence: 87%

Dermal Reactions to Insulin Therapy

Paley

Tunbridge

1952

Diabetes

View full text Add to dashboard Cite

One of the earliest papers on insulin therapy by Banting and his colleagues described a slight induration of the subcutaneous tissue and reddening of the skin immediately surrounding the point of injection. At this time Joslin and his co-workers stated that induration had been seen frequently at the site of insulin injections and described four cases of urticaria developing among the first 83 diabetic patients treated. Later, redness and swelling were observed to follow the injection of protamine insulin, and similar reactions have been described following the use of globin insulin.

show abstract

“…17 ' 18 We found the mean time of onset was 13 days from the first injection. 17 ' 18 We found the mean time of onset was 13 days from the first injection.…”

Section: Time Of Onset and Durationmentioning

confidence: 87%

Dermal Reactions to Insulin Therapy

Paley

Tunbridge

1952

Diabetes

View full text Add to dashboard Cite

show abstract

“…In fact, the 3 individuals who produced no precipitating antibody whatever despite high titers of non-precipitating antitoxin, denied any history of personal or familial allergy. This is not particularly surprising in view of the findings of others (27,28) that the development of allergy in patients under treatment with liver extract, insulin, and other materials cannot be predicted on the basis of the patient's past history.…”

Section: Discussionmentioning

confidence: 91%

Immunochemical Studies of Antitoxin Produced in Normal and Allergic Individuals Hyperimmunized With Diphtheria Toxoid: I. Relationship of Skin Sensitivity to Purified Diphtheria Toxoid to the Presence of Circulating, Non-Precipitating Antitoxin

Kuhns

Pappenheimer

1952

Journal of Experimental Medicine

View full text Add to dashboard Cite

The present study is the first of a series designed to use hypersensitivity of the immediate type to diphtheria toxin or toxoid as a model for the study of the hay-fever type of allergy. The use of the toxin-antitoxin system in the experimental study of allergy possesses several distinct advantages over less well characterized systems such as are encountered in patients sensitive to pollens, grasses, etc. In the first place, diphtheria toxin and toxoid are available in a high state of purity and are reasonably well characterized proteins. Secondly, it is possible to measure by means of the sensitive rabbit intracutaneous test both toxin and antitoxin with considerable accuracy even when they are present in very low concentration. Finally, it has been demonstrated that administration of a single dose of purified diphtheria toxoid into Schick-negative adults is frequently followed by a rapid and high antitoxin response. Quantitative studies (1) have shown that no other antibody is formed in appreciaable amount and therefore the toxin-antitoxin reaction in human beings immunized in this way closely approximates a single antigen-antibody system. Prausnitz and Kustner in 1921 (2) first demonstrated in an allergic individual a serum factor which was capable of causing local sensitivity of the wheal and erythema type in the skin of normal human subjects. (Sensitivity to fish was passively transferred in the original experiments.) Prausnitz and Kustner showed that the reaction was highly specific but they were unable to demonstrate either precipitating or complement-fixing antibodies in the patient's serum, nor was it capable of passively sensitizing guinea pigs to anaphylactic shock. Moreover, they were unable to demonstrate by means of skin tests neutralization of the allergen in extracts of fish by the patient's serum. Most of the original observations were subsequently confirmed and extended to include passive transfer of sensitivity to a variety of antigenic materials.

show abstract

Allergy

Rackemann¹

1942

Arch Intern Med (Chic)

View full text Add to dashboard Cite

Allergy to insulin, liver, pituitary, pancreas, estrogens, enzymes, and similar substances

Cited by 20 publications

References 77 publications

Dermal Reactions to Insulin Therapy

Dermal Reactions to Insulin Therapy

Immunochemical Studies of Antitoxin Produced in Normal and Allergic Individuals Hyperimmunized With Diphtheria Toxoid: I. Relationship of Skin Sensitivity to Purified Diphtheria Toxoid to the Presence of Circulating, Non-Precipitating Antitoxin

Allergy

Contact Info

Product

Resources

About