Allergy and Mucosal Eosinophil Infiltrate in Ulcerative Colitis

D’Arienzo, A.; Manguso, Francesco; Astarita, C.; D’Armiento, Francesco Paolo; Scarpa, Raffaele; Gargano, Domenico; Scaglione, Giuseppe; Vicinanza, G; Bennato, R.; Mazzacca, G

doi:10.1080/003655200750023598

Cited by 34 publications

(42 citation statements)

References 32 publications

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“…The coexistence of IBD and allergy has become more frequent in recent decades, and many studies indicate a connection between these two pathologies [4,5,6,7,8,9,10,11,12,13,20,21,22]. At present, we do not know whether food sensitization is a risk for or a result of intestinal inflammation.…”

Section: Discussionmentioning

confidence: 90%

“…They found a low rate of sensitization in UC patients before the appearance of clinical symptoms was demonstrated. This observation, together with the finding that the first appearance of intestinal symptoms in most UC patients occurs simultaneously with or precedes allergic symptoms [13], suggests that UC facilitates the onset of allergic symptoms in subjects sensitized to environmental antigens. Moreover, many patients with celiac disease are sensitized to many other food proteins.…”

Section: Introductionmentioning

confidence: 99%

“…The involvement of allergy as a cause or consequence of UC was further analyzed by D'Arienzo et al [13]. They found a low rate of sensitization in UC patients before the appearance of clinical symptoms was demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, the incidence of cow's milk protein allergy in IBD patients is higher than that observed in a healthy population (20.9% in UC and 8.5% in CD patients compared to 2.8% in the normal population) [12] or even higher and reaching 50% of prevalence in UC patients when referring to general allergic diseases not limited to cow's milk protein allergy [13]. …”

Section: Introductionmentioning

confidence: 99%

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Active Colitis Exacerbates Immune Response to Internalized Food Antigens in Mice

Cueto-Sola

Bailón²,

Utrilla³

et al. 2013

Int Arch Allergy Immunol

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Background: Previous studies have indicated that colitis increases intestinal permeability to food antigens. This condition also generates an immunoreactive milieu in the gut, which may exacerbate or counteract allergy reactions. This, along with the fact that both colitis and allergy are being codiagnosed more frequently, means the scientific interest on the immune relation between these pathologies is increasing. We evaluated the immune response to an internalized food antigen that was initiated during a concomitant active intestinal inflammatory response. Methods: An ovalbumin (OVA)-induced immune response was analyzed in healthy mice and in mice suffering from colitis induced by the administration of dinitrofluorobenzene/dinitrosulfonic acid (DNFB/DNS) at the moment of OVA challenge. The OVA-induced clinical score and allergy response both in plasma and in splenocyte cultures from these animals were compared. Results: Although no differences were observed in the allergy clinical score, the concomitant active colitis led to an increase in the immune response to OVA antigen, as shown by increased spleen size and OVA-induced splenocyte proliferation, exacerbated expression of total and OVA-specific IgG1 levels, increased colonic IL-4 expression and OVA-induced IL-4 and IL-5 cytokine expression in spleen cells. Conclusions: Our results indicate that animals with active colitis undergo an exacerbated immune response to an internalized antigen. This finding could be relevant for the allergy management of patients presenting simultaneously with chronic colitis.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Active Colitis Exacerbates Immune Response to Internalized Food Antigens in Mice

Cueto-Sola

Bailón²,

Utrilla³

et al. 2013

Int Arch Allergy Immunol

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“…All these observations suggest that the eosinophils and their mediators are actively involved in the inflammatory process of both Crohn's disease and ulcerative colitis Their role is certainly more than that of an Ôinnocent bystanderÕ (95). However, Crohn's disease bears many features of a T H1 type inflammation, whereas ulcerative colitis is closer aligned with allergies (98). It must therefore be expected that the functional role of the eosinophils is different in these two entities.…”

Section: Eosinophilia Associated With ôNoneosinophilicõ Inflammationsmentioning

confidence: 92%

The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract

Straumann

Simon

2003

Allergy

107

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Eosinophils and the gastrointestinal tract interact in an intimate and enigmatic relationship. Under healthy conditions, the presence of eosinophils is limited almost exclusively to the digestive tract mucosa where they exert several effector and immunoregulatory functions. While their precise function in the gastrointestinal tract is not completely understood, it is likely that, together with different T cell subsets, eosinophils are involved in maintaining the immunologic homeostastis across the mucosal barrier under resting conditions. Eosinophils also play a role in several inflammatory conditions, such as intestinal infections, hypersensitivity reactions, primary eosinophilic inflammations and several other chronic intestinal disorders. Depending on the responsible trigger, their effects may be beneficial or detrimental. Here, we discuss the available information regarding the physiological and pathological functions of eosinophils within the gastrointestinal tract.

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Evaluation of tissue eosinophilia in the pouch and afferent limb in patients with restorative proctocolectomy

Shen

Plesec

Remzi

et al. 2008

Inflammatory Bowel Diseases

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Allergy and Mucosal Eosinophil Infiltrate in Ulcerative Colitis

Abstract: UC patients frequently show several markers of allergy. In particular, our data suggest an association between ulcerative colitis, tissue eosinophilia, and type-I allergy.

Cited by 34 publications

References 32 publications

Active Colitis Exacerbates Immune Response to Internalized Food Antigens in Mice

Active Colitis Exacerbates Immune Response to Internalized Food Antigens in Mice

The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract

Evaluation of tissue eosinophilia in the pouch and afferent limb in patients with restorative proctocolectomy

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