Allergie Diseases in Animals

Wittich, F W

doi:10.1159/000313566

Cited by 6 publications

(6 citation statements)

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“…Chronic asthma has only rarely been reported in animals [1,2], Antigen challenge of actively or pas sively immunized animals is commonly used to inves tigate immediate allergic bronchoconstriction. A number of investigators have attempted to produce a model of asthma by repeated exposure of animals to specific antigens [3][4][5][6][7], In a previous study we chroni cally exposed immunized guinea pigs to aerosolized ovalbumin (OA) and showed that repeated exposure resulted in a progressive decrease in responsiveness and a diminution of the pulmonary function abnor malities produced by aerosol challenge [8].…”

Section: Introductionmentioning

confidence: 99%

Physiological and Immunological Effects of Chronic Antigen Exposure in Immunized Guinea Pigs

Andrew¹,

Schellenberg²,

Hogg³

et al. 1984

Int Arch Allergy Immunol

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Antigenic tolerance was induced in previously sensitized guinea pigs by challenging with ovalbumin (OA) aerosol 1 h/day, 5 days/week for 6 weeks. Reactivity was assessed visually and by lung mechanics. Sera from tolerant and sensitized animals showed comparable titers of antigen-specific antibody by passive cutaneous anaphylaxis with 6-hour, 4-day (heated serum) and 7-day sensitizations. In vitro contractile responses of airway smooth muscle revealed comparable histamine responses in sensitized and tolerant guinea pigs but decreased OA sensitivity in smooth muscle from tolerant animals. Although lung histamine content was equivalent in the two groups, antigen-induced histamine release from chopped lung preparations was significantly less in tolerant animals at a low antigen concentration. We conclude that antigen-induced histamine release is impaired in tolerant animals.

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Section: Introductionmentioning

confidence: 99%

Physiological and Immunological Effects of Chronic Antigen Exposure in Immunized Guinea Pigs

Andrew¹,

Schellenberg²,

Hogg³

et al. 1984

Int Arch Allergy Immunol

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“…As early as 1941, Wittich described spontaneous asthma in a dog due to ragweed that was associated with an antibody capable of sensitizing the skin of dogs [82]. As early as 1941, Wittich described spontaneous asthma in a dog due to ragweed that was associated with an antibody capable of sensitizing the skin of dogs [82].…”

Section: Anaphylactic-type Antibodies In Experimental Animalsmentioning

confidence: 99%

“…The conceptual climate expressed by this question was undoubtedly strengthened by the work proceeding at the same time on the nature of anaphylactic-type antibodies in experimental animals. As early as 1941, Wittich described spontaneous asthma in a dog due to ragweed that was associated with an antibody capable of sensitizing the skin of dogs [82]. In 1943, Weil and Reddin reported that cattle with skin sensitivity to ragweed possessed a heat-labile antibody that could sensitize the skin of cattle (cited in [82]).…”

Section: Anaphylactic-type Antibodies In Experimental Animalsmentioning

confidence: 99%

Elements of the history of our present concepts of anaphylaxis, hay fever and asthma

Becker

1999

Clin Experimental Allergy

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“…The dog was chosen for these studies because naturally occurring al lergies are well documented in this species [3,26,30,38,43,50,53]. Naturally occur ring pollenosis has been studied more exten sively in the dog than in any species other than man [30,31,[33][34][35][36] and resembles pollenosis in man.…”

Section: Introductionmentioning

confidence: 99%

Respiratory Allergy in the Dog: Induction by the Respiratory Route and the Effect of Passive Antibody

Faith¹,

Hessler²,

Small³

1977

Int Arch Allergy Immunol

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A technique for inducing hypersensitivity to prairie sage pollen (Artemisia gnopheles) in the dog was developed. The allergen induced skin reactivity in most dogs and respiratory hypersensitivity in 7 of the 17 animals tested. The respiratory hypersensitivity resembled naturally occurring respiratory allergies in both man and dog. The route of allergy induction resembles the natural route and it is felt that this system provides a useful model system for the study of respiratory allergies. Animals in which respiratory hypersensitivity was induced were used to investigate the role of passive ‘blocking’ antibody in respiratory allergy. It was observed that passive antibody will greatly inhibit the respiratory response to inspired allergen while completely inibiting the cutaneous response. The results of these studies are discussed in relation to other studies.

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Allergie Diseases in Animals

Cited by 6 publications

References 0 publications

Physiological and Immunological Effects of Chronic Antigen Exposure in Immunized Guinea Pigs

Physiological and Immunological Effects of Chronic Antigen Exposure in Immunized Guinea Pigs

Elements of the history of our present concepts of anaphylaxis, hay fever and asthma

Respiratory Allergy in the Dog: Induction by the Respiratory Route and the Effect of Passive Antibody

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