Allergic Rhinitis and Asthma Among Adolescents with Psoriasis: A Population-based Cross-sectional Study

Abstract

In a population-based cross-sectional study among adolescents, psoriasis was shown to be significantly associated with allergic rhinitis and asthma. The association between psoriasis and asthma was found only in moderate-to-severe psoriasis, while the association with allergic rhinitis was not dependent on psoriasis severity. Few studies have reported an association between psoriasis and atopic comorbidity in adults.A population-based cross-sectional study was performed to investigate the possible association of psoriasis with allergic rhinitis or asthma among adolescents. Adolescents (16-18 years of age) medically evaluated for military service between 1999 and 2014 were included. Medical records were obtained from the database of the Israeli Defense Forces. Of the 887,765 adolescents studied, 3,112 patients had psoriasis (56.1% mild; 43.9% moderate-to-severe). Psoriasis was significantly associated with allergic rhinitis (adjusted odds ratio (aOR) 1.3; 95% confidence interval (CI) 1.2-1.5) and asthma (aOR 1.2; 95% CI 1.0-1.3), compared with controls without psoriasis. Moderate-to-severe psoriasis was associated with allergic rhinitis (aOR 1.3; 95% CI 1.1-1.5) and asthma (aOR 1.5; 95% CI 1.2-1.7), while mild psoriasis was only associated with allergic rhinitis (aOR 1.4; 95% CI 1.2-1.6). In conclusion, amongst adolescents, psoriasis was found to be associated with allergic rhinitis and asthma.

Elevation of IgE in patients with psoriasis: Is it a paradoxical phenomenon?

“…A previous study showed that RAST was positive in 58 and 22% of patients with chronic plaque psoriasis and active psoriasis, respectively ( 79 ). Several studies showed similar results, in which the positive RAST tests were significantly higher in patients with chronic plaque psoriasis(CPP) than those with progressive psoriasis ( 50 , 80 ). However, contradictory results have also been reported.…”

Alerjik rinit ve astım olan hastalarda prick testi sonuçlarımız

“…Alerjik rinit ve bronşiyal astım birlikteliği sık görüldüğü bildirilmiştir (11,12). Çalışmamızda da literatürle uyumlu olarak çalışma grubunun yaklaşık yarısında bu iki alerjik hastalığın birlikteliği görülmüştür.…”

Chronic Inflammation as the Underlying Mechanism of the Development of Lung Diseases in Psoriasis: A Systematic Review

“…Older patients with psoriasis (≥50 years) had a higher risk of asthma (OR = 1.64, 95% CI: 1.44-1.88) and chronic obstructive pulmonary disease (HR = 2.19, 95% CI: 1.27-3.77) than younger ones [12,23]. In children, observational studies suggest an increased risk of asthma compared to the general population, but the data are inconsistent [13,[17][18][19]. Furthermore, the increased susceptibility to asthma in children was associated with moderate to severe psoriasis [17].…”

“…In children, observational studies suggest an increased risk of asthma compared to the general population, but the data are inconsistent [13,[17][18][19]. Furthermore, the increased susceptibility to asthma in children was associated with moderate to severe psoriasis [17].…”