Elevation of IgE in patients with psoriasis: Is it a paradoxical phenomenon?

Shi, Leyao; Liu, Chen; Xiong, Huabao; Shi, Dongmei

doi:10.3389/fmed.2022.1007892

Cited by 6 publications

(6 citation statements)

References 192 publications

(207 reference statements)

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“…Hypersensitivity reaction I begins with Th2, which will stimulate the differentiation of B cells into plasma cells, producing IgE. Furthermore, a cross-reaction occurs among basophils, mast cells, and IgE, making basophils release inflammatory mediators chemotactic for eosinophils (Shi et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Humoral Inflammatory Markers of Total Immunoglobulin E (IgE) Exposure on Palm Oil Plantation Pesticide Sprayers

Awantari,

Susilowati

2023

Kemas

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Pesticides are often used in oil palm plantations to prevent disturbing animals and plants. Pesticide sprayers are vulnerable to pesticide exposure which can reduce cholinesterase levels is an indicator of pesticide poisoning. Long-term pesticide exposure and excessive doses cause the production of free radicals in the body, thereby increasing inflammatory markers, one of which is total IgE. This study aimed to describe cholinesterase and total IgE levels in oil palm farmers. This study used the quantitative-descriptive research method. The sampling was conducted at PT. X in Sanggau District of West Kalimantan Province. Examining cholinesterase levels used the Architec c-8000 device with the DGKC butyrylthiocholine 37°C method, while total IgE used the immunochemmiluminescent method with the Immulite 2000 device. The examination was carried out at the Prodia National Reference Lab in Jakarta. Based on the cholinesterase measurement results taken from 133 workers who underwent medical check-ups, 20 data were taken that were close to the threshold value less than normal to examine total IgE levels. The results obtained from the overview of cholinesterase levels showed that 20 pesticide sprayers (100%) had normal cholinesterase levels, and four (20%) had normal total IgE levels. Pesticide exposure will decrease cholinesterase levels, and increase IgE levels.

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Section: Resultsmentioning

confidence: 99%

Humoral Inflammatory Markers of Total Immunoglobulin E (IgE) Exposure on Palm Oil Plantation Pesticide Sprayers

Awantari,

Susilowati

2023

Kemas

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“…Thus, our results with the STAT6 inhibitor were insufficient to show an indispensable role for Th2 responses, including IL-4/IL-13 and IgE/IgG1 in imiquimod-induced and OVA-exacerbated psoriasis, although Th2 responses are thought to participate in psoriasis development. 5) The beneficial potential of the STAT6 inhibitor on imiquimod-induced psoriasis should be examined in more detail, and, in turn, the importance of the role of Th2 in human psoriasis may become an attractive research focus.…”

Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 99%

“…4) Additionally, the Th2 response is expected to be implicated in psoriasis. 5) However, the relationship between the two diseases remains controversial. Dai et al 6) revealed that the presence of each disease increases the risk of the other, but Kirsten et al 7) found that the prevalence of atopic diseases was lower in patients with psoriasis than in those without.…”

Section: Introductionmentioning

confidence: 99%

Co-induced Allergic Response to an Unrelated Allergen Exacerbates Imiquimod-Induced Psoriasis in Mice

Yamaki,

Egi,

Segawa

et al. 2023

Biological & Pharmaceutical Bulletin

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Psoriasis is classically regarded as a Th1 response-dominant disease believed to be antagonized by the Th2 response, which is responsible for allergic diseases, such as atopic dermatitis. The roles of these responses in psoriasis and the relationship between psoriasis and atopic dermatitis have received increasing attention because it is estimated that more than one million patients are concomitantly affected by psoriasis and atopic dermatitis. To address this, we attempted to determine the characteristics of imiquimod-induced psoriasiform lesions in mice with a concomitant allergic response after co-application of the unrelated allergen ovalbumin onto the skin. Imiquimod cream containing ovalbumin was successively applied to the right back skin of hairless HR female mice. Psoriasiform scores were determined for 11 days, and then, the resected skin thickness, spleen weight, and serum antibody levels were examined. In some experiments, mice were allowed free access to ovalbumin-containing water for 10 days before skin application to induce oral tolerance. Imiquimod cream induced psoriasis, and its severity increased upon simultaneous ovalbumin treatment. Increases in anti-ovalbumin IgG2a levels, a Th1 response indicator, and IgG1 and IgE levels, Th2 response indicators, were mediated by ovalbumin addition. Oral tolerance against ovalbumin effectively decreased ovalbumin-exacerbated imiquimod-induced psoriasis, in parallel with a decrease in levels of anti-ovalbumin antibodies. These results suggest that the concomitant allergic response induced by ovalbumin application exacerbates imiquimod-induced psoriasis. This implies that allergic responses to unrelated allergens might exacerbate psoriasis in humans and that modulating such responses could be an effective new approach to treat psoriasis.

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“…Moreover, cytokines contribute to inflammation and exacerbation of atopic lesions . Indeed, atopic patients exhibit higher levels of immunoglobulins E (IgE), which is overproduced as a consequence of inflammatory response and contributes to the prolongation of atopic lesions . Furthermore, the genetic alterations in cell-mediated immune responses lead to disruption of the stratum corneum (SC), the outermost layer of skin .…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Nanofiber Patches with Sustainable Oil Delivery Eliminate Inflammation in Atopic Skin

Sroczyk,

Tarasiuk,

Talar

et al. 2024

ACS Appl. Mater. Interfaces

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Atopic skin is dry and itchy and lacks integrity. Impaired skin barrier results from altered lipid composition of the skin. A crucial skin lipid, cholesterol, provides flexibility and homeostasis of the cell membranes' lipid bilayer. Cholesterol-based creams and natural oils, especially blackcurrant seed oil, are beneficial for skin care as they hydrate the skin and improve its integrity. The major atopic symptom, skin dryness, can be overcome by the application of porous patches enhanced with cholesterol and natural oil. The base of the patches is constructed of polyimide (PI) nanofibers with cholesterol coatings and externally added blackcurrant seed oil. The presence of cholesterol in PI mats hinders the passage of oil through the patches to the skin, resulting in sustained and prolonged skin hydration. The theoretical and numerical investigations of oil dynamics in porous mats confirmed the experimental results, showing a prolonged skin hydration effect up to 6 h. Additionally, as demonstrated by in vivo tests on atopic mice, cholesterol patches lower serum immunoglobulin E levels and expression of proinflammatory cytokines in the skin, thereby accelerating skin healing. Our results hold great promise for the longterm application of the patches in atopic dermatitis treatment.

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Elevation of IgE in patients with psoriasis: Is it a paradoxical phenomenon?

Cited by 6 publications

References 192 publications

Humoral Inflammatory Markers of Total Immunoglobulin E (IgE) Exposure on Palm Oil Plantation Pesticide Sprayers

Humoral Inflammatory Markers of Total Immunoglobulin E (IgE) Exposure on Palm Oil Plantation Pesticide Sprayers

Co-induced Allergic Response to an Unrelated Allergen Exacerbates Imiquimod-Induced Psoriasis in Mice

Cholesterol Nanofiber Patches with Sustainable Oil Delivery Eliminate Inflammation in Atopic Skin

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