Allergic Rhinitis and Aspirin-Exacerbated Respiratory Disease as Predictors of the Olfactory Outcome after Endoscopic Sinus Surgery

Katotomichelakis, Michael; Riga, Maria; Davris, S; Trιpsianis, Grigorios; Simopoulou, Mara; Nikolettos, Nikolaos; Simopoulos, Konstantinos; Danielides, Vassilios

doi:10.2500/ajra.2009.23.3325

Cited by 31 publications

(28 citation statements)

References 32 publications

(48 reference statements)

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“…In this study, we observed that AERD patients have significantly higher SNOT-20 GAV scores when compared to CRSwNP or CRSsNP. This is in accordance with previous data showing that QoL and olfactory function of AERD patients is more compromised when compared to those CRS patients who are not aspirin-intolerant [21,23]. In our analysis of the various subcategories of the SNOT-nasal, otologic, sleep, and emotional symptoms-it became evident that the different SNOT outcome is mainly due to nasal symptom burden.…”

Section: Discussionsupporting

confidence: 92%

“…In this respect, patients with non-type 2 disease or CRSsNP suffer from fewer recurrences of the disease after surgical treatment and have a lower incidence of comorbidities than seen in type-2 inflammation or CRSwNP [4]. Furthermore, patients with AERD have a higher endoscopic polyp score [21], greater impairment of olfactory function [22,23], and a higher risk of revision surgery when compared to those suffering from nasal polyposis alone [24,25]. However, despite clear differences in CRS subtypes, studies evaluating whether this is also reflected in QoL outcomes are missing.…”

Section: Introductionmentioning

confidence: 99%

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Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease

Schneider

Campion

Villazala-Merino

et al. 2020

JCM

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Chronic rhinosinusitis (CRS) is a common disease that substantially impairs the quality of life (QoL). Here, we aimed to assess patients' QoL in different subtypes of CRS and correlated this with nasal polyp size to improve the clinical understanding of the burden of disease. In this retrospective single-center study, 107 patients with the following diagnoses were analyzed: CRS without nasal polyps (CRSsNP), CRS with nasal polyps (CRSwNP), or aspirin-exacerbated respiratory disease (AERD). Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) scores and their correlation with endoscopic Total Polyp Scores (TPS) were evaluated. The mean SNOT-20 GAV scores were highest in patients with AERD (AERD = 43.4, CRSwNP = 36.3, CRSsNP = 30.9). A statistically significant correlation of total SNOT-20 GAV score with TPS was observed in CRSwNP patients (r = 0.3398, p = 0.0195), but not in AERD patients (r = 0.2341, p = 0.1407). When analyzing single SNOT-20 parameters, a strong correlation with TPS was observed for blockage/congestion of the nose, particularly in AERD patients (r = 0.65, p < 0.0001). The impact of nasal polyp size on the QoL differs amongst the subgroups of CRS. Nasal symptoms have the greatest impact on QoL in patients suffering from AERD. CRSwNP and AERD patients should be separately analyzed in clinical investigations and interpretations due to significant differences in QoL.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease

Schneider

Campion

Villazala-Merino

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…However, a recent study has reported that patients with asthma, CRSwNP, and aspirin sensitivity have postoperative quality of life outcomes that are comparable to patients with CRSwNP who are not aspirin sensitive [27]. The olfactory recovery after FESS for CRSwNP is significantly affected by the concomitant presence of AERD [32].…”

Section: Extent Of Disease At Baseline and Comorbiditiesmentioning

confidence: 95%

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

López-Chacón

Mullol

Pujols

2015

Curr Allergy Asthma Rep

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Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS. In addition to clinical traits, numerous biological markers, with known etiopathogenic roles in CRS, have been associated to difficult-to-treat or recalcitrant CRS. This review summarizes the existing knowledge of the clinical and biological markers associated to difficult-to-treat or uncontrolled severe CRS.

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“…The recovery of a normal sense of smell after medical and surgical treatment appears to be less likely in AERD patients compared with patients with allergic rhinitis. 8 Recurrence of nasal polyps after medical or surgical treatment is typical in AERD patients and has been reported to be nearly three times higher than in aspirin-tolerant asthmatic patients. 9 …”

Section: Natural Historymentioning

confidence: 99%

Immunomodulatory Treatments for Aspirin Exacerbated Respiratory Disease

Moebus

Han

2012

Am J Rhinol�Allergy

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Allergic Rhinitis and Aspirin-Exacerbated Respiratory Disease as Predictors of the Olfactory Outcome after Endoscopic Sinus Surgery

Cited by 31 publications

References 32 publications

Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease

Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

Immunomodulatory Treatments for Aspirin Exacerbated Respiratory Disease

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