Allergic respiratory disease in grain workers: The role of storage mites

Blainey, A. D.; Topping, M. D.; Ollier, S.; Davies, Robert J.

doi:10.1016/0091-6749(89)90411-9

Cited by 92 publications

(43 citation statements)

References 18 publications

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“…Storage mites are the cause of occupational allergic diseases of bakers (21) and food industrial workers (2,25) and among residents in agricultural environments (4). Koreans store uncooked rice in rice bins or chests in their homes, and thus the storage mite, T. putrescentiae, is often found on kitchen floors in urban areas (10).…”

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confidence: 99%

Immunoglobulin E Reactivity of Recombinant Allergen Tyr p 13 from Tyrophagus putrescentiae Homologous to Fatty Acid Binding Protein

Jeong

Kim

Lee

et al. 2005

Clin Vaccine Immunol

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The storage mite, Tyrophagus putrescentiae, is one of the important causes of allergic disorders. Fifteen allergenic components were demonstrated in storage mite by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting, but only the group 2 allergen Tyr p 2 has been cloned and characterized. In this study, we attempted to identify and characterize new allergens from T. putrescentiae, which is a dominant species of storage mite in Korea. Expressed sequence tags were analyzed to identify possible storage mite allergens, and the cDNA sequence encoding a protein homologous to fatty acid binding protein, a mite group 13 allergen, was identified and named Tyr p 13. Its deduced amino acid sequence showed 61.1 to 85.3% identity with other mite group 13 allergens. The recombinant protein was expressed in Escherichia coli using a pET 28b vector system, and its allergenicity was investigated by enzyme-linked immunosorbent assay (ELISA). The recombinant allergen was detected in 5 of 78 (6.4%) T. putrescentiae-positive sera tested, and it inhibited 61.9% of immunoglobulin E binding to crude extract at an inhibitor concentration of 10 g/ml by inhibition ELISA using serum from the patient who showed the strongest reaction by ELISA. In this study, a novel allergen was identified in T. putrescentiae. This allergen could be helpful for more-detailed characterizations of storage mite allergy.

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confidence: 99%

Immunoglobulin E Reactivity of Recombinant Allergen Tyr p 13 from Tyrophagus putrescentiae Homologous to Fatty Acid Binding Protein

Jeong

Kim

Lee

et al. 2005

Clin Vaccine Immunol

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“…Others who have achieved better return rates and data quality in defined populations include Gannon et al [10], who attempted to obtain records in an entire cohort of electroplaters and received satisfactory records from 78% of workers after two visits. Blainey et al [6] studied 133 grain dockers and farmers by seeing them in clinic and giving them a mini-Wright peak flow meter with a set of written instructions and obtained recordings from 62% of this epidemiologically defined cohort. Cullen et al [8] found that, out of 38 autobody shop workers given full training on how to take peak flow readings, only 24 (63%) provided adequate data.…”

Section: Discussionmentioning

confidence: 99%

“…Previous work has shown computer-assisted analysis of serial PEF records to have a sensitivity of 73 -86% and a specificity of 74 -100% [2 -4]. The ability to obtain records of diagnostic value varies considerably with success rates of 52% in laboratory animal workers, 54% in previously diagnosed workers, 62% in grain workers, 63% in autobody shop workers, 78% of workers given an electronic peak flow meter and 78% of electroplaters [5][6][7][8][9][10]. Most of these studies achieved these results by visiting workers and/or seeing them in clinic.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of occupational asthma

Burge

1989

Clin Experimental Allergy

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Summary Accurate diagnosis of occupational asthma takes time, enthusiasm and a particular knowledge of the work situation, as well as expertise in the use of diagnostic procedures. The prognosis of patients with occupational asthma is probably improved by removing them from the responsible agent as soon as possible after sensitization occurs. However, it is much easier to make the diagnosis while the worker is still exposed to the cause of the problem. Early referral for expert investigation is therefore important.

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“…House-dust mites, together with cat and dog allergens, have been considered the most important indoor factors increasing the risk of allergic reactions. In addition, storage mites have been documented as a cause of allergic symptoms, especially in cases of rural occupational exposure at sites such as farms, dairy barns, and grain elevators (9)(10)(11)(12)(13)(14)(15)(16). However, nothing is known about the occupational exposure of laboratory animal workers to mites.…”

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confidence: 99%