Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines

RETRACTED: Why are we vaccinating children against COVID-19?

“…The vaccine is injected into the deltoid muscle, at which time it contributes to inflammation at the injection site due in part to the LNP and potentially to anaphylaxis from the LNP PEG-2000 component. Some of the injected material stays at the injection site, where it combines with cells through endocytosis to express spike protein on the cell surface, stimulating the adaptive immune system to eventually produce antibodies to the spike protein ( Moghimi, 2021 ).…”

Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 Vaccine in Saudi Arabia

“…Severe reactogenicity (grade ≥3) and the need for hospitalization were not reported by the included vaccinees in this study. There had been no reported anaphylactic reactions among AstraZeneca Oxford COVID-19 vaccine recipients (Moghimi, 2021). Previous studies had shown the occurrence of anaphylactic reactions after AstraZeneca COVID-19 vaccine and one study reported thrombotic events at the time when 17 million people were vaccinated (Tobaiqy et al, 2021).…”

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

“…This approach could lead to the development of a broader spectrum of complement-evading multifunctional nanomedicines and nanotheranostics. These dendrimers might also prove useful in vaccine stabilization and overcoming anaphylactoid reactions seen with PEGylated lipid nanoparticles (e.g., as in COVID-19 vaccines), where a role for anti-PEG antibodies has been speculated 51 . From a broader perspective, we also envisage dendrimeric (e.g., pyrrolidone-terminated) coating of drug-eluting stent surfaces, contact lenses and (haemo)dialysis membrane filters to minimise protein binding and complement activation.…”