Allergic manifestations of contact lens wearing

Solomon, Abraham

doi:10.1097/aci.0000000000000311

Cited by 21 publications

(18 citation statements)

References 32 publications

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“…Giant papillary conjunctivitis (GPC), an ocular allergic condition most often seen in contact lens (CL) wearers, is characterized by papillary hypertrophy, mucous discharge, itching, redness, and foreign body sensation [22]. Several clinical trials evaluated the use of LE 0.5% suspension for CL-associated GPC.…”

Section: Giant Papillary Conjunctivitismentioning

confidence: 99%

Loteprednol etabonate for inflammatory conditions of the anterior segment of the eye: twenty years of clinical experience with a retrometabolically designed corticosteroid

Comstock¹,

Sheppard

2018

Expert Opinion on Pharmacotherapy

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Topical corticosteroids are an important pharmacotherapy for the management of various inflammatory conditions affecting the anterior segment of the eye. However, medications in this class are associated with well-known risks including increased intraocular pressure (IOP) and development of cataracts. The topical corticosteroid loteprednol etabonate (LE) was developed with the specific intention of minimizing these side effects. Areas covered: The focus of this review is to examine published efficacy and safety data for LE, a drug engineered to undergo rapid metabolism to inactive metabolites with the goal of improved safety. Two decades of clinical research focused on LE formulations are reviewed, including the use of LE in combination with tobramycin. The cumulative body of experience affirms the concept that the molecular design of LE confers certain safety benefits without compromising the desired anti-inflammatory efficacy of a topical corticosteroid. Expert opinion: Loteprednol etabonate is a mainstay for topical therapy of a wide variety of commonplace and niche conditions of the ocular surface and the anterior segment, including in the healing post-operative patient. Its versatility and safety allow eye care providers to recommend both acute induction as well as chronic maintenance therapy with appropriate follow-up.

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Section: Giant Papillary Conjunctivitismentioning

confidence: 99%

Loteprednol etabonate for inflammatory conditions of the anterior segment of the eye: twenty years of clinical experience with a retrometabolically designed corticosteroid

Comstock¹,

Sheppard

2018

Expert Opinion on Pharmacotherapy

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“…In addition, there is a need to identify risk factors such as the coexistence of allergy, for example, which can further induce or exacerbate the symptoms of CLD leading to discontinuation of contact lens wear. 80 , 81 …”

Section: Managing Cldmentioning

confidence: 99%

Contact lens wear and dry eyes: challenges and solutions

Markoulli¹,

Kolanu²

2017

OPTO

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The number of contact lens wearers worldwide has remained relatively stable over the past decade, despite the investment that has gone into contact lens technology. This is largely because 10%–50% of wearers dropout of contact lens wear within 3 years of commencement; the most common reason cited being contact lens discomfort (CLD). Of the symptoms reported, sensation of dry eye is the most common. Given the outcome of reduced wearing time, increased chair time, and ultimate contact lens discontinuation, the challenge is to identify the warning signs of CLD early on. Clinically detectable changes such as conjunctival staining, conjunctival indentation, conjunctival epithelial flap formation, lid wiper epitheliopathy, Demodex blepharitis, and meibomian gland dysfunction have been linked to CLD, highlighting the need to perform regular aftercare visits to identify these changes. At a cellular level, conjunctival metaplasia and reduced goblet cell density have been linked to CLD, leading to a downstream effect on the tear film breakup time of contact lens wearers. These factors suggest a strong link between CLD and friction, raising the need to target this as a means of minimizing CLD. The purpose of this review is to identify the clinical signs that relate to CLD as a means of earlier detection and management in order to combat contact lens dropout.

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“…Interestingly, family Oxalobacteraceae was prevalently detected in the conjunctival microbiota of lens wearers 25 and contact lens wearing is in turn associated with ocular allergy. 26 Rothia was also enriched in samples from participants with AC, including Rothia aeria (P = 1.8×10 -4 ) and Rothia dentocariosa (P = 0.0010). In addition, we detected the enrichment of Moraxella catarrhalis in AC (P = 0.0033).…”

Section: Dysbiosis Of Conjunctival Microbiome In Allergic Conjunctivitismentioning

confidence: 97%

Characterization of conjunctival microbiome dysbiosis associated with allergic conjunctivitis

Liang

Zhang

et al. 2020

Preprint

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Background: Evidence shows that the microbiome plays an important role in allergic diseases. The associations between the conjunctival microbiome dysbiosis and ocular allergy remain unknown. This study investigates the characteristics of the conjunctival microbiome in allergic conjunctivitis (AC). Methods: We performed metagenomic shotgun sequencing on conjunctival samples from 48 healthy subjects and 39 patients with AC. The AC group comprised 21 patients with seasonal allergic conjunctivitis or perennial allergic conjunctivitis (SAC/PAC) and 18 patients with vernal keratoconjunctivitis (VKC). Results: We identified a signature microbiome associated with the dysbiosis of conjunctival microbiota on the ocular surface of patients with AC. Interestingly, SAC/PAC and VKC harbor distinct microbial communities. Specifically, Brevibacterium aurantiacum is enriched in SAC/PAC, whereas a group of Streptococcus species and Haemophilus parainfluenzae are enriched in VKC. Conclusion: Dysbiosis of conjunctival microbiome is found on the ocular surface of AC patients. These results suggest a new microbial mechanism of AC and provide a potential target for AC treatment.

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Allergic manifestations of contact lens wearing

Cited by 21 publications

References 32 publications

Loteprednol etabonate for inflammatory conditions of the anterior segment of the eye: twenty years of clinical experience with a retrometabolically designed corticosteroid

Loteprednol etabonate for inflammatory conditions of the anterior segment of the eye: twenty years of clinical experience with a retrometabolically designed corticosteroid

Contact lens wear and dry eyes: challenges and solutions

Characterization of conjunctival microbiome dysbiosis associated with allergic conjunctivitis

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