Allergic contact stomatitis caused by neem leaves (<i>Azadirachta indica</i>)

Ambooken, Betsy; Sarin, A; Asokan, Neelakandhan; Abraham, A.M López

doi:10.1111/cod.12732

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…Natural products alone have low solubility, rapid blood clearance, potential toxicity to unwanted sites, and low bioavailability and, thus, require a good lipophilic carrier such as liposome formulations for adequate drug delivery in clinical settings ( 107 ). Moreover, allergic dermatitis to natural products such as neem may also be an associated risk for certain individuals ( 99 ). Despite these limitations, the therapeutic potential of natural products can be explored as drug delivery research using liposomes is promising, and monitoring for allergic reactions is feasible ( 107 ).…”

Section: Discussionmentioning

confidence: 99%

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2

Kaur,

Dey,

Rawat

et al. 2024

Front. Immunol.

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BackgroundThis review analyzed the magnitude of the COVID-19 pandemic globally and in India and the measures to counter its effect using natural and innate immune booster molecules. The study focuses on two phases: the first focuses on the magnitude, and the second on the effect of antioxidants (natural compounds) on SARS-CoV-2.MethodsThe magnitude of the prevalence, mortality, and comorbidities was acquired from the World Health Organization (WHO) report, media, a report from the Ministry of Health and Family Welfare (MoHFW), newspapers, and the National Centre of Disease Control (NCDC). Research articles from PubMed as well as other sites/journals and databases were accessed to gather literature on the effect of antioxidants.ResultsIn the elderly and any chronic diseases, the declined level of antioxidant molecules enhanced the reactive oxygen species, which in turn deprived the immune system.ConclusionInnate antioxidant proteins like sirtuin and sestrin play a vital role in enhancing immunity. Herbal products and holistic approaches can also be alternative solutions for everyday life to boost the immune system by improving the redox balance in COVID-19 attack. This review analyzed the counteractive effect of alternative therapy to boost the immune system against the magnitude of the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2

Kaur,

Dey,

Rawat

et al. 2024

Front. Immunol.

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“…[ 49 50 ] Allergic contact stomatitis has been reported after the ingestion of neem leaves. [ 51 ] Jadhav reported a case series of lip leukoderma secondary to the use of neem twigs for oral hygiene. Three of the seven patients developed delayed depigmentation when patch tested with powdered neem leaves and neem twig scrapings.…”

Section: Tradition To Sciencementioning

confidence: 99%

Neem in Dermatology

Gopinath¹,

Karthikeyan²

2021

Indian Journal of Dermatology

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“…[2][3][4][5][6][7] Use of leaves for religious purposes has also been linked to a case of contact stomatitis. 8 Patch testing with the TRUE-Test and the undiluted product provided by the patient "as is" was performed. Prior literature has tested this product "as is" negative in controls.…”

mentioning

confidence: 99%