Allergic contact dermatitis from spironolactone

Corazza, Monica; Strumìa, Renata; Lombardi, Anna Rita

doi:10.1111/j.1600-0536.1996.tb02421.x

Cited by 9 publications

(7 citation statements)

References 8 publications

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“…Spironolactone, a synthetic steroid derivative of 17‐spirolactone with antiandrogenic effects, at the moment is no more used as not included in current guidelines . However, this molecule showed allergenic properties and was found to be responsible for few cases of ACD in the past . The 1% pet.…”

Section: Adverse Effects To Anti‐acne Drugsmentioning

confidence: 99%

Contact dermatitis to topical acne drugs: a review of the literature

Foti

Romita

Borghi

et al. 2015

Dermatologic Therapy

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Acne vulgaris is a chronic dermatological disorder that affects the majority of teenagers in the Western world. Topical therapy is widely used to treat mild-moderate acne and is known as well-tolerated thanks to its low systemic toxicity, although associated to skin adverse effects. Acne seems to be associated also to an intrinsic alteration of the epidermal barrier, regarding both the upper and the follicular stratum corneum that promotes the onset of such local side effects. The commonest one is irritant contact dermatitis, an event of frequent observation occurring with erythema, burning, dryness, scaling, and itching, usually characterized by low severity and limited duration. Among topical acne drugs, retinoids are the most irritating ones. Another side effect is allergic contact dermatitis: it is rare and mainly associated to benzoyl peroxide.

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Section: Adverse Effects To Anti‐acne Drugsmentioning

confidence: 99%

Contact dermatitis to topical acne drugs: a review of the literature

Foti

Romita

Borghi

et al. 2015

Dermatologic Therapy

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“…Although 1% pet. is the most suitable concentration recommended for spironolactone patch test (2), for canrenone we have found positive reactions even with lower concentrations, as 0.1% pet. New cases may probably be difficult to find, knowing the current scarce use of this substance.…”

Section: Clinical Casementioning

confidence: 57%

“…In reference with its topical use, it has not been related with any adverse effect; in fact, there are no published cases of allergic contact dermatitis produced by canrenone. Indeed, very few cases of allergic contact dermatitis produced by topical spironolactone have been reported in the literature, last of them published more than 10 years ago (2).…”

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confidence: 99%

Allergic contact dermatitis produced by canrenone

et al. 2007

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“…112 Topical spironolactone has also been used to treat idiopathic hirsutism and AGA. 112,113 Ten cases of allergic contact dermatitis caused by topical spironolactone 2% or 5% have been reported in the literature. 113 …”

Section: Topical Spironolactone For Acne Vulgarismentioning

confidence: 98%