Allergic contact dermatitis from Kathon 893

Octylisothiazolinone, an additional cause of allergic contact dermatitis caused by leather: case series and potential implications for the study of cross-reactivity with methylisothiazolinone

“…Interestingly, through skin contact with OIT-treated textiles and leather goods, not only those who are occupationally exposed, but also consumers, may be at risk for OIT sensitization (Table S2). In 1992, Oleaga et al (5) were the first to describe OIT as the cause of foot dermatitis in a patient wearing leather shoes; the manufacturer admitted the use of it as a fungicide (no chemical analysis was performed at that time). Rani et al (16), and more recently Febriana et al (17), identified another 4 and 2 patients, respectively, all presenting with foot dermatitis possibly caused by OIT in leather shoes.…”

Non‐occupational allergic contact dermatitis from 2‐N‐octyl‐4‐isothiazolin‐3‐one in a Japanese mattress gel‐sheet used for cooling

“…It is used in latex and oil‐based paints (1), adhesives, wood preservatives, cutting oils for the preservation of leather (2), plastic manufacture (3), and in the textile industry (4). Although occupational allergic contact dermatitis from octylisothiazolinone has been reported (1–4), only one case of non‐occupational allergic contact dermatitis from leather shoes containing octylisothiazolinone has been reported so far (2). Here, we report two cases of non‐occupational allergic contact dermatitis from octylisothiazolinone used in a new Japanese product for mattresses.…”

Contact dermatitis from 2‐n‐octyl‐4‐isothiazolin‐3‐one in a PhD student

“…It is used in latex paints (1, 2), adhesives, wood preservatives, cutting oils, for the preservation of leather (3) and in plastics manufacture (4, 5). Allergic contact dermatitis from 2‐n‐octyl‐4‐isothiazolin‐3‐one is rare, but has previously been reported through exposure to paints (1, 2) and also, in one case, to leather shoes (3). We believe that this is the first reported case of occupational allergic contact dermatitis from 2‐n‐octyl‐4‐isothiazolin‐3‐one in a laboratory worker.…”