Allergic contact dermatitis due to a moisturizing body cream with chitin

Cleenewerck, M.-B.; Martin, P.; Laurent, Didier

doi:10.1111/j.1600-0536.1994.tb01973.x

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…Beside the oral route, chitosan has also been proved safe when applied on wounded skin and is well established as a useful material in wound dressing [176][177][178]. However, two single-case reports of contact dermatitis to creams containing chitosangluconate, with confirmation of chitosan intolerance after skin patch tests, have been described [179,180]. As for nasal toxicity, 100 l of a 0.25% solution of chitosan glutamate (MW 205 kDa, DD 83%) administered once daily for 7 days in humans was shown to have no effect on nasal clearance times or the mucosal histology [156].…”

Section: In Vivo Datamentioning

confidence: 98%

Chitosan Formulations as Carriers for Therapeutic Proteins

Andrade

Antunes²,

Nascimento³

et al. 2011

CDDT

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Protein drugs represent a significant part of the new pharmaceuticals coming on the market every year and are now widely spread in therapy to treat or relief symptomatology related to many metabolic and oncologic diseases. The delivery of therapeutic proteins is still a major drawback against their maximum pharmacodynamic due to their physicochemical properties, poor stability, permeability and biodistribution. Despite the fact that the parenteral route remains the primary route of protein administration, research continues on non-parenteral delivery routes. However, the high molecular weight of proteins, combined with their hydrophilic and charged nature, renders transport through membranes very difficult. In this regard, the biopolymer chitosan exhibits several favorable biological properties, such as biocompatibility, biodegradability, low-toxicity and mucoadhesiveness, which made it a promising candidate for the formulation of protein drugs. The success of a protein formulation depends not only on the stability of the delivery system but also on their ability to maintain the native structure and activity of the protein during preparation and the delivery, as well as during longterm storage of the formulation. Chitosan-based delivery systems have been proposed as valid approaches to provide such protective conditions. The development of novel protein delivery systems based on chitosan is a rising subject irrespective of the intended route of administration. In this review, the different approaches recently exploited to formulate and deliver therapeutic proteins are underlined.

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Section: In Vivo Datamentioning

confidence: 98%

Chitosan Formulations as Carriers for Therapeutic Proteins

Andrade

Antunes²,

Nascimento³

et al. 2011

CDDT

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“…Chitin and chitosan are considered as having low allergenic potential. We found only 1 case of allergic contact dermatitis due to chitosan gluconate, contained in a moisturizing body cream reported by Cleenewerk et al (2).…”

Section: Discussionmentioning

confidence: 52%

Contact dermatitis due to a cream containing chitin and a Carbitol

Pereira

1998

Contact Dermatitis

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“…In total, we retrieved 195 related articles. We found six articles [6][7][8][9][10][11] (for a total of seven cases including our case) that reported allergic reactions caused by chitosan, including three males and four females, aged between 10 and 73 years old.…”

Section: Literature Reviewmentioning

confidence: 99%