2022
DOI: 10.1002/ccr3.6596
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Anaphylaxis induced by intra‐articular injection of chitosan: A case report and literature review

Abstract: Generally, we consider chitosan being a safe, nontoxic natural polymer with wide clinical applications. However, allergic reactions caused by chitosan have been reported on rare occasions. We report here a case of allergy and perform a literature review.

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Cited by 4 publications
(3 citation statements)
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References 21 publications
(29 reference statements)
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“…Although the erythema worsened with standing 14 h after aspiration of the joint fluid, no respiratory or circulatory symptoms occurred. In another case report of intra‐articular chitosan‐induced anaphylaxis, the patient completely recovered 1 h after the injection 5 . Therefore, although joint fluid aspiration might not be necessary for all cases of anaphylaxis due to joint injection, the agent injected into the joint is important to our decision.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the erythema worsened with standing 14 h after aspiration of the joint fluid, no respiratory or circulatory symptoms occurred. In another case report of intra‐articular chitosan‐induced anaphylaxis, the patient completely recovered 1 h after the injection 5 . Therefore, although joint fluid aspiration might not be necessary for all cases of anaphylaxis due to joint injection, the agent injected into the joint is important to our decision.…”
Section: Discussionmentioning
confidence: 99%
“…In another case report of intra‐articular chitosan‐induced anaphylaxis, the patient completely recovered 1 h after the injection. 5 Therefore, although joint fluid aspiration might not be necessary for all cases of anaphylaxis due to joint injection, the agent injected into the joint is important to our decision. These two cases indicate that aspiration of joint fluid might be one of the treatment options for anaphylactic shock following an intra‐articular injection of diclofenac etalhyaluronate sodium because the trigger might remain in the joint cavity for a longer time because of the drug's long half‐life.…”
Section: Discussionmentioning
confidence: 99%
“…Hydrolyzed products formed during this process and its further impact over gastrointestinal tract must be assessed. Natural polymers such as chitosan can cause allergic reactions in some people since they are derived from biological sources [73,74].…”
Section: Edible Films: Are They Edible?mentioning
confidence: 99%