Allergic contact dermatitis caused by alkyl glucosides

Abstract

Allergic contact dermatitis caused by alkyl glucosides in cosmetics does occur, and might be more frequent than suspected. In view of their common use, their identification as allergenic culprits is important.

Allergic contact dermatitis caused by benzoic acid and lauryl glucoside in a sunscreen

“…Lauryl glucoside is a non‐ionic biodegradable surfactant made from plants; it is a member of the alkyl glucoside group, and is used in cleaning agents and emulsions. Within the alkyl glucoside group, decyl glucoside is the one that is most frequently involved in allergies to sunscreens, as part of Tinosorb™ M . Although cross‐reactions between the different alkyl glucosides are frequent, in our case we did not observe positive reactions to Tinosorb™ M (ingredient of the sunscreen) or decyl glucoside (5% pet.)…”

Alkyl glucosides: Newly identified allergens in foam wound dressings

“…Glucopon 625, which we specifically report on here, is an aqueous solution of alkyl glucosides (C 10 ‐C 16 ); we suspect that it potentially also contains lauryl glucoside (C 18 ) as an impurity, in line with the observation that industrial glucoside samples, similarly to the patch test material of decyl glucoside, apparently also may contain alkyl glucosides with different chain lengths. Glucopon 625 is commercialized by BASF (Ludwigshafen, Germany) for use in the production of polyurethane foams. Such foams are based on the reaction of highly hydrophilic polyether alcohols containing a high level of ethylene oxide with isocyanates, and water as the chemical blowing agent.…”

“…Alkyl glucosides are low‐risk allergens that are used as non‐ionic, mild surfactants in rinse‐off and leave‐on cosmetics, antiseptics, hair dyes, and food. Recently, glucoside‐containing foam dressings, which are used in the treatment of leg ulcers, have also been reported as a cause of allergic contact dermatitis. We here report a third case of allergic contact dermatitis caused by a foam wound dressing in which the presence of lauryl glucoside (CAS no.…”

Potential Allergens in Disposable Diaper Wipes, Topical Diaper Preparations, and Disposable Diapers

“…Allergic contact dermatitis to decyl glucosides in sunscreen, soaps, and shampoos has been reported, and there is 1 case report of ACD to cetearyl glucoside (a cross-reactor) in hygiene wipes in an adult. 74 In children younger than 5 years, no RPPT reaction was seen to decyl glucoside. 5 In children younger than 18 years, 2.3% had an RPPT reaction to decyl glucoside.…”