Allergic contact dermatitis caused by octylisothiazolinone in a leather car seat: Case report and emergence of octylisothiazolinones in leather goods in Switzerland

Tehrany, Yassaman Alipour; André, R; Bugey, Aurélie; Santimaria, Doriane; Edder, Patrick; Piletta, Pierre

doi:10.1111/cod.14188

Cited by 4 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 In the last few years, some cases of non-occupational ACD to leather goods containing OIT added for its strong fungicidal properties during the tanning process and leather transport were reported. 11,12 In our case, MI, MCI and OIT were detected in the analysed leather, cloth and foam rubber samples, while OIT also in plastic disc. The highest level of these isothiazolinones were detected in the leather sample and lower levels in the cloth, foam rubber and plastic disc ones.…”

Section: Discussionsupporting

confidence: 47%

“…Rarely, isothiazolinones are described to be responsible for ACD due to leather and textiles not only due to contamination from detergents, 10 but also to their addition during the production process to prevent microbial contamination of various textiles (e.g., garments and mattresses) and leather wear 11 . In the last few years, some cases of non‐occupational ACD to leather goods containing OIT added for its strong fungicidal properties during the tanning process and leather transport were reported 11,12 . In our case, MI, MCI and OIT were detected in the analysed leather, cloth and foam rubber samples, while OIT also in plastic disc.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Wireless over‐ear headphones: A new source of allergic contact dermatitis to isothiazolinones

Caroppo,

Stingeni,

Goracci

et al. 2024

Contact Dermatitis

View full text Add to dashboard Cite

Psoralen-containing plants have a significant role in the treatment of vitiligo in both traditional and modern medicine systems.There are many modern medicines that contain psoralens isolated from plants (rather than artificially synthesised psoralens), which are administered in regulated protocols for photochemotherapy using artificial UV-A light (PUVA) or sunlight as the source of UV-A (PUVAsol). Even therapies developed from traditional systems also mention titration of dose and duration of sun exposure, and gradual increase, similar to PUVAsol therapy in modern medicine. But such traditional preparations are often used unsupervised by the patients. They often use excessive dose of the active component or excessive sun exposure without subsequent photoprotection, often intentionally in hopes of getting faster pigmentation, or inadvertently due to unregulated preparations leading to severe adverse effects. The topical formulations can lead to very high concentration of the drug in the skin, which can be more injurious and have lower thresholds of sun exposure to produce phototoxic reactions. 4 Frequently, after resolution of acute dermatitis, there might be development of slight hyperpigmentation over the exposed normal skin and some repigmentation over the vitiligo patches. It is suggested that the perifollicular melanocytes undergo significant damage during the acute dermatitis episodes, limiting the response to future phototherapy interventions. [4][5][6] Mild hypopigmented scarring, as seen in our patient, can also occur, which also limits future response.In conclusion, severe phytophototoxic reactions to psoralen-containing plants taken for treatment for vitiligo can present as thermal burns. When introduced to such therapies, patients must be sensitised about the potential adverse effects of overdose or overexposure and the need for complete photoprotection apart from the strictly titrated duration of sun exposure similar to PUVAsol therapy.

show abstract

Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Wireless over‐ear headphones: A new source of allergic contact dermatitis to isothiazolinones

Caroppo,

Stingeni,

Goracci

et al. 2024

Contact Dermatitis

View full text Add to dashboard Cite

show abstract

“…Reports on cases of contact allergy to BIT, OIT, DCOIT, and causative exposures, including non‐occupational and occupational exposure, are listed in Table 2 35–54 . Various types of products and materials included biocidal products in industry, detergents, leather articles (furniture and shoes), oils, paint, plastic and rubber articles, printing ink, and textiles (e.g., clothing and bed sheets).…”

Section: Skin Sensitizationmentioning

confidence: 99%

Increasing non‐cosmetic exposure and sensitization to isothiazolinones require action for prevention: Review

Lidén,

White

2024

Contact Dermatitis

View full text Add to dashboard Cite

Frequent use of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI in cosmetic products has been the main cause of widespread sensitization and allergic contact dermatitis to these preservatives (biocides). Their use in non‐cosmetic products is also an important source of sensitization. Less is known about sensitization rates and use of benzisothiazolinone (BIT), octylisothiazolinone (OIT), and dichlorooctylisothiazolinone (DCOIT), which have never been permitted in cosmetic products in Europe. BIT and OIT have occasionally been routinely patch‐tested. These preservatives are often used together in chemical products and articles. In this study, we review the occurrence of contact allergy to MI, BIT, OIT, and DCOIT over time, based on concomitant patch testing in large studies, and case reports. We review EU legislations, and we discuss the role of industry, regulators, and dermatology in prevention of sensitization and protection of health. The frequency of contact allergy to MI, BIT, and OIT has increased. The frequency of contact allergy to DCOIT is not known because it has seldom been patch‐tested. Label information on isothiazolinones in chemical products and articles, irrespective of concentration, is required for assessment of relevance, information to patients, and avoidance of exposure and allergic contact dermatitis.

show abstract