Allergic conditions and risk of glioma and meningioma in the CERENAT case-control study

Pouchieu, Camille; Piel, Clément; Migault, Lucile; Carles, Camille; Fabbro-Perray, P.; Loiseau, Hugues; Guillamo, Jean-Sébastien; Lebailly, Pierre; Baldi, Isabelle

doi:10.1007/s11060-018-2816-6

Cited by 15 publications

(35 citation statements)

References 36 publications

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“…In that same year, an expanded genome-wide association study of meningioma, including 2,000 patients and 6,000 controls, was initiated by the National Institutes of Health ( 17 ), which earned a significant contribution in understanding genetic factors of meningioma. Notably, the results, including an inverse relationship between hormones and allergies, provided a clear framework and direction for further meningioma study as well as the establishment of comparative oncology ( 18 – 20 ). Furthermore, a genotype analysis in 65 samples using high-density single nucleotide polymorphism (SNP) arrays found associations between meningiomas and variation in PIAS2, KATNAL2, TCEB3C, TCEB3CL , and CTNNA3 , especially TARDBP mutations with amyotrophic lateral sclerosis ( 21 ), which further improves the identification of susceptible sites of meningioma by genomics.…”

Section: Genomicsmentioning

confidence: 87%

Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis

2020

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Meningiomas are common intracranial tumors that can be cured by surgical resection in most cases. However, the most disconcerting is high-grade meningiomas, which frequently recur despite initial successful treatment, eventually conferring poor prognosis. Therefore, the early diagnosis and classification of meningioma is necessary for the subsequent intervention and an improved prognosis. A growing body of evidence demonstrates the potential of multi-omics study (including genomics, transcriptomics, epigenomics, proteomics) for meningioma diagnosis and mechanistic links to potential pathological mechanism. This thesis addresses a neglected aspect of recent advances in the field of meningiomas at multiple omics levels, highlighting that the integration of multi-omics can reveal the mechanism of meningiomas, which provides a timely and necessary scientific basis for the treatment of meningiomas.

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Section: Genomicsmentioning

confidence: 87%

Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis

2020

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“…Second, further study is needed to determine whether the AA genotype of rs4252707 affects the expression of MDM4 . Third, increasing evidences suggest an association between the history of allergy or asthma and glioma risk 50 , 51 . However, because of the lack of the relevant environmental data in our cohort, it is unclear whether this would affect the observed association in the study.…”

Section: Discussionmentioning

confidence: 99%

MDM4 contributes to the increased risk of glioma susceptibility in Han Chinese population

Sun

Yan

Fang

et al. 2018

Sci Rep

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Recently, MDM4 gene has been reported to be a susceptibility gene for glioma in Europeans, but the molecular mechanism of glioma pathogenesis remains unknown. The aim of this study was to investigate whether common variants of MDM4 contribute to the risk of glioma in Han Chinese individuals. A total of 24 single-nucleotide polymorphisms (SNPs) of the MDM4 gene were assessed in a dataset of 562 glioma patients (non-glioblastoma) and 1,192 cancer-free controls. The SNP rs4252707 was found to be strongly associated with the risk of non-GBM (P = 0.000101, adjusted odds ratio (OR) = 1.34, 95% confidence interval (CI) = 1.16–1.55). Further analyses indicated that there was a significant association between A allele of rs4252707 associated with the increased non-GBM risk. Haplotype analysis also confirmed a result similar to that of the single-SNP analysis. Using stratification analyses, we found the association of rs4252707 with an increased non-GBM risk in adults (≥18 years, P = 0.0016) and individuals without IR exposure history (P = 0.0013). Our results provide strong evidence that the MDM4 gene is tightly linked to genetic susceptibility for non-GBM risk in Han Chinese population, indicating a important role for MDM4 gene in the etiology of glioma.

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“…In this study, allergy/atopy of long latency (≥10 years) was associated with a reduced risk of developing brain cancer (rate ratio = 0.60, 95% CI, 0.43–0.83) [25]. Last, a recent multicenter case-control study carried out in four areas in France in 2004–2010 has explored the relationship between allergy (e.g., asthma, eczema, rhinitis/hay fever and other allergic conditions) and the risk of glioma in 273 glioma cases and 982 matched controls [26]. In addition to confirming previous findings, this work highlighted a dose-effect relationship between the number of allergic conditions and the inverse association with glioma risk and a stronger relationship in women [26].…”

Section: Epidemiology Of Gliomas and Gbm In Allergic Subjectsmentioning

confidence: 99%

“…Last, a recent multicenter case-control study carried out in four areas in France in 2004–2010 has explored the relationship between allergy (e.g., asthma, eczema, rhinitis/hay fever and other allergic conditions) and the risk of glioma in 273 glioma cases and 982 matched controls [26]. In addition to confirming previous findings, this work highlighted a dose-effect relationship between the number of allergic conditions and the inverse association with glioma risk and a stronger relationship in women [26]. To avoid the possibility that allergic inflammation might be somehow influenced by (or be the effect of) brain tumor itself, Schwartzbaum and colleagues have investigated germline polymorphisms as potential biomarkers of GBM susceptibility, selecting five single nucleotide polymorphisms (SNPs) strongly associated with asthma and allergic conditions [27].…”

Section: Epidemiology Of Gliomas and Gbm In Allergic Subjectsmentioning

confidence: 99%

Allergic Signs in Glioma Pathology: Current Knowledge and Future Perspectives

Costanza

Finocchiaro

2019

Cancers

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Historically restrained to immune defense against parasite infections, allergic inflammation has been recently rediscovered to protect from a wide array of environmental triggers, such as xenobiotics and carcinogens, which can induce DNA damage and ultimately lead to cancer development. Moreover, cells and mediators typical of allergic responses can importantly modulate the tissue inflammatory milieu, which represents a crucial gatekeeper towards the acquisition of malignancy by cancer cells through immune escape. Numerous studies have described an inverse association between allergies and glioma development. Mast cells, key players of allergic reactions, have been recently found at increased numbers in glioblastoma multiforme (GBM), the most common and lethal primary brain tumor, and they have been implicated in GBM pathogenesis. In this review, we summarize epidemiological studies and discuss the main evidence highlighting a potential interplay between allergic responses, and glioma formation and progression. Last, we draw future lines of research for better clarification whether and through which mechanisms allergic inflammation might impact on gliomagenesis. The comprehension of the immune mechanisms favoring or counteracting tumor growth might open the path to novel immunotherapy approaches.

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Allergic conditions and risk of glioma and meningioma in the CERENAT case-control study

Cited by 15 publications

References 36 publications

Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis

Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis

MDM4 contributes to the increased risk of glioma susceptibility in Han Chinese population

Allergic Signs in Glioma Pathology: Current Knowledge and Future Perspectives

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