Allergic Bronchopulmonary Mycosis Due to &lt;i&gt;Schizophyllum commune&lt;/i&gt; Treated Effectively with Voriconazole

Ishiguro, Takashi; Kagiyama, Naho; Kojima, Ayako; Yamada, Masami; Nakamoto, Yoshiaki; Takaku, Yotaro; Shimizu, Yoshihiko; Kurashima, Kazuyoshi; Takayanagi, Noboru

doi:10.2169/internalmedicine.0668-17

Cited by 12 publications

(18 citation statements)

References 15 publications

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“…We previously identified a S. commune antigen Sch c1 [5]. Although the increased titer against Sch c1 was auxiliary used for the diagnosis of S. commune infection, serum samples are required for the method [6]. Further options, especially non-invasive and rapid options, are being awaited for for the diagnosis of diseases by S. commune.…”

Section: Introductionmentioning

confidence: 99%

Identification of Volatile Sulfur Compounds Produced by Schizophyllum commune

Toyotome

Takino

Takaya

et al. 2021

JoF

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Schizophyllum commune is a causative agent of allergic bronchopulmonary mycosis, allergic fungal rhinosinusitis, and basidiomycosis. Diagnosis of these diseases remains difficult because no commercially available tool exists to identify the pathogen. Unique volatile organic compounds produced by a pathogen might be useful for non-invasive diagnosis. Here, we explored microbial volatile organic compounds produced by S. commune. Volatile sulfur compounds, dimethyl disulfide (48 of 49 strains) and methyl ethyl disulfide (49 of 49 strains), diethyl disulfide (34 of 49 strains), dimethyl trisulfide (40 of 49 strains), and dimethyl tetrasulfide (32 of 49 strains) were detected from headspace air in S. commune cultured vials. Every S. commune strain produced at least one volatile sulfur compound analyzed in this study. Those volatile sulfur compounds were not detected from the cultures of Aspergillus spp. (A. fumigatus, A. flavus, A. niger, and A. terreus), which are other major causative agents of allergic bronchopulmonary mycosis. The last, we examined H2S detection using lead acetate paper. Headspace air from S. commune rapidly turned the lead acetate paper black. These results suggest that those volatile sulfur compounds are potent targets for the diagnosis of S. commune and infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Identification of Volatile Sulfur Compounds Produced by Schizophyllum commune

Toyotome

Takino

Takaya

et al. 2021

JoF

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“…As to laboratory examination, nearly half (12/25) of the patients showed elevation of eosinophils, 7 of 25 patients showed increased serum total IgE, 10 of 25 patients revealed elevation of serum antibody to S. commune (including specific IgE and IgG).In addition, elevated serum aspergillus fumigatus IgG and/ or serum aspergillus fumigatus IgE in ABPM due to S. commune were found in some cases, which might be related to the presence of antigenic cross-reactivity between S. commune and aspergillus fumigatus. [11,14] The imaging of chest CT of pneumonia caused by S. commune can be classified into followings according to the literature: Mucous plugs or glove finger sign. These were the most common manifestation; Pulmonary fungal balls or uniformly dense strips.…”

Section: Discussionmentioning

confidence: 99%

“…[11] Recently, accurate identification has been increasingly achieved by molecular methods using nucleotide sequencing of the internal transcribed spacer, 18S rRNA gene and/or large subunit rRNA gene. [1,26] While metagenomic next-generation Sigler [2] 1995 1995 Amitani [5] 1996 Japan Improved and no recurrence 5 Lizasa [7] 2001 Japan 6 Kawayama [8] 2003 Bulajic [23] 2006 UK Tullio [24] 2008 Italy Roan [25] 2009 Taiwan Improved and no recurrence 11 Ogawa [10] 2011 Japan Seki [12] 2014 Japan 18 Kobayashi [13] 2016 Japan [14] 2018 Japan Ito [15] 2019 sequencing is gradually applied in the detection of S. commune. [12] It can be misdiagnosed as invasive pulmonary aspergillosis or allergic bronchopulmonary aspergillosis/ABPM because of the similar clinical manifestations and imaging.…”

Section: Discussionmentioning

confidence: 99%

“…Despite of the increasing number of cases of S. Commune infections to pulmoanry recent years, most cases were reported from Japan. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] In addition, there is still unclear about the clinical presentation, imaging, therapeutic agents and prognosis of pneumonia to S. Commune. We herein reported a rare case of pulmonary mycosis due to S. Commune in a diabetic patient and relevant published global literature were also reviewed.…”

Section: Introductionmentioning

confidence: 99%

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Pneumonia caused by Schizophyllum commune in a patient with diabetes: A case report and comprehensive literature review

et al. 2023

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Rationale: Schizophyllum commune (S. commune) is a basidiomycete bracket fungus that rarely causes invasive fungal infections. It is often misdiagnosed as other invasive fungal disease because of its atypical clinical features. Here we report a case of pneumonia due to S commune and review the relevant literature. Patient concerns and diagnoses: A 55-year-old male with a history of diabetes and poor glycemic control presented with cough and sputum for half a month. Laboratory examination showed elevated peripheral blood eosinophils, bronchoalveolar lavage fluid eosinophils and increased serum total immunoglobulin E. Chest computed tomography revealed a gloved finger sign and consolidation in the middle lobe of the right lung and the upper lobe of the left lung. Bronchoscopy revealed thick white mucous plugs in the left lingular bronchus, which could be removed partially by suctioning. The culture of bronchoalveolar lavage fluid and bronchoscopy brush specimens grew cottony white mold in sabouraud dextrose agar. Pneumonia caused by S. commune was diagnosed based on clinical features and microbial methods. Interventions and outcomes: Voriconazole combined with inhaled budesonide and formoterol (inhaled corticosteroids + long-acting β-2 receptor agonist) were given, and his symptoms improved. The count of peripheral blood eosinophils and serum total immunoglobulin E decreased after 1 month. Repeated chest computed tomography showed remarkable improvement over the previous lesions. Lessons: Although rarely reported, infections in the lungs caused by S commune should be reminded especially in patients with immunocompromised. This case illustrates the risk factors, clinical symptoms and imaging features of the pneumonia caused by S. commune. It also further highlights the diagnosis and treatment of this disease through reviewing relevant literature.

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“…While the diagnosis of ABPA is usually straightforward if suspected, occasionally, the disorder needs to be differentiated from the following conditions: Aspergillus -sensitized bronchial asthma 109 ; severe asthma with fungal sensitization, an entity described by the presence of fungal sensitization and severe asthma, where patients do not meet the criteria for ABPA 110 111 ; pulmonary tuberculosis (in high tuberculosis prevalence areas) 112 ; eosinophilic pneumonia (acute and chronic) and Churg-Strauss syndrome 113 ; and tropical pulmonary eosinophilia 114 .…”

Section: Differential Diagnosismentioning

confidence: 99%

Allergic bronchopulmonary aspergillosis

et al. 2020

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Allergic bronchopulmonary aspergillosis (ABPA) is an inflammatory disease caused by immunologic reactions initiated against Aspergillus fumigatus colonizing the airways of patients with asthma and cystic fibrosis. The common manifestations include treatment-resistant asthma, transient and fleeting pulmonary opacities and bronchiectasis. It is believed that globally there are about five million cases of ABPA, with India alone accounting for about 1.4 million cases. The occurrence of ABPA among asthmatic patients in special clinics may be as high as 13 per cent. Thus, a high degree of suspicion for ABPA should be entertained while treating a patient with bronchial asthma, particularly in specialized clinics. Early diagnosis and appropriate treatment can delay (or even prevent) the onset of bronchiectasis, which suggests that all patients of bronchial asthma should be screened for ABPA, especially in chest clinics. The current review summarizes the recent advances in the pathogenesis, diagnosis and management of ABPA.

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Allergic Bronchopulmonary Mycosis Due to <i>Schizophyllum commune</i> Treated Effectively with Voriconazole

Cited by 12 publications

References 15 publications

Identification of Volatile Sulfur Compounds Produced by Schizophyllum commune

Identification of Volatile Sulfur Compounds Produced by Schizophyllum commune

Pneumonia caused by Schizophyllum commune in a patient with diabetes: A case report and comprehensive literature review

Allergic bronchopulmonary aspergillosis

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