Allergic angiitis and granulomatosis. Prolonged remission induced by combined prednisone--azathioprine therapy

Cooper, Barry; Bacal, Edita; Patterson, Roy

doi:10.1001/archinte.138.3.367

Cited by 33 publications

(9 citation statements)

References 4 publications

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“…In light of the sustained and general escalation of asthma therapy prior to CSS onset (table 1), the most plausible explanation for linking montelukast to CSS appears to be confounding by indication due to gradually worsening asthma. Albeit poorly documented, this scenario fits the concept of a prodromal phase characterised by increasing frequency and severity of asthma attacks before vasculitis emerges as the hallmark of CSS 28 37 38. Moreover, we confirmed previous observations7 9 that the time from montelukast initiation to CSS onset frequently lasted many months.…”

Section: Discussionsupporting

confidence: 57%

The leucotriene receptor antagonist montelukast and the risk of Churg-Strauss syndrome: a case-crossover study

Hauser

Mahr

Metzler

et al. 2008

Thorax

134

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Background: There has been some concern that leucotriene receptor antagonists might precipitate the onset of Churg-Strauss syndrome (CSS). A study was undertaken to investigate the relationship between the leucotriene receptor antagonist montelukast and the onset of CSS. Methods: Medication histories of 78 patients with CSS from France and Germany were retraced by questioning the patients, treating physicians and dispensing pharmacists, and from medical records. Using a case-crossover research design, exposures to montelukast and other asthma medications during the 3-month ''index'' period immediately preceding the onset of CSS were compared with those of four previous 3-month ''control'' periods. Odds ratios (ORs) were computed by conditional logistic regression. Results: The ORs for CSS onset were 4.5 (95% CI 1.5 to 13.9) for montelukast, 3.0 (95% CI 0.8 to 10.5) for inhaled long-acting b 2 agonists, 1.7 (95% CI 0.5 to 5.4) for inhaled corticosteroids and 4.0 (95% CI 1.3 to 12.5) for oral corticosteroids. Montelukast exposure during control periods increased temporally over

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Section: Discussionsupporting

confidence: 57%

The leucotriene receptor antagonist montelukast and the risk of Churg-Strauss syndrome: a case-crossover study

Hauser

Mahr

Metzler

et al. 2008

Thorax

134

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“…Prolonged remission has also been reported with combined corticosteroid and azathioprine therapy (6). Our observations underscore the importance of early diagnosis and aggressive treatment of this disorder with corticosteroids and immunosuppressors.…”

supporting

confidence: 72%

Eosinophilic vasculitic neuropathy in the Churg‐Strauss syndrome

Herrara

Spalding

1986

Arthritis & Rheumatism

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“…If detected early, CSS would be more responsive to corticosteroid therapy, while cases with advanced vasculitis may require the addition of more powerful immunosuppressive drugs. (11) Our patient was put on intravenous methylprednisolone, followed by oral steroids. He was initially prescribed oral cyclophosphamide, as per conventional textbook guidelines of the management of CSS.…”

Section: Discussionmentioning

confidence: 99%

Churg-Strauss syndrome presenting with focal segmental glomerulosclerosis without proteinuria: response to unconventional therapy

Guha

Thakur²,

Ray³

et al. 2013

SMedJ

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Churg-Strauss syndrome (CSS), or allergic granulomatosis, is a rare disease manifested by tissue infiltration, hypereosinophilia and vasculitis. Renal involvement may be seen in up to 50% of cases. We report the case of a 25-yearold man who presented with a history of fever for two months, tingling, numbness, and paraesthesia of the upper limbs and left lower limb, along with diarrhoea for one month and an inability to walk for the past seven days. Serial laboratory investigations helped to reach the final diagnosis of CSS with mononeuritis multiplex, and skin, pulmonary and gastrointestinal involvement with hypertension. This is due to renal involvement in the form of focal segmental glomerulosclerosis without any nephrotic range proteinuria, which is a very rare clinical entity. The patient's symptoms were relieved after the administration of an unconventional mode of therapy.

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Allergic angiitis and granulomatosis. Prolonged remission induced by combined prednisone--azathioprine therapy

Cited by 33 publications

References 4 publications

The leucotriene receptor antagonist montelukast and the risk of Churg-Strauss syndrome: a case-crossover study

The leucotriene receptor antagonist montelukast and the risk of Churg-Strauss syndrome: a case-crossover study

Eosinophilic vasculitic neuropathy in the Churg‐Strauss syndrome

Churg-Strauss syndrome presenting with focal segmental glomerulosclerosis without proteinuria: response to unconventional therapy

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