Allergic and non-allergic skin diseases in children of Ukraine: a retrospective study of the prevalence and incidence over the past 24 years

O.P., Volosovets; Bolbot, Yu.K.; G.V., Beketova; Березенко, В.С.; Уманец, Т.Р.; Rechkina, O.O.; I.O., Міtiuriaeva-Korniyko; T.М., Volosovets; T.V., Pochinok

doi:10.26641/2307-0404.2021.3.242265

Cited by 6 publications

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“…Ś ƌƈƉƟƑƇƂƃ žſƊƆźƌƂƌ (ŚŞ) -Ɛſ ƏƊƈƇƟƑƇſ ƁźƏżƈƊƘżźƇƇƙ ƒƄƟƊƂ, ƋƉƊƂƑƂƇſƇſ Żź-ŽźƌƖƆź ŽſƇſƌƂƑƇƂƆƂ, ƟƆƍƇƇƂƆƂ ƌź ſƄƈ-ƅƈŽƟƑƇƂƆƂ ƎźƄƌƈƊźƆƂ [9]…”

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The significance of Staphylococcus aureus skin colonization and the yeast Malassezia in children for the development of atopic dermatitis

Mozyrska¹

2022

MPU

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Patients with atopic dermatitis have a disrupted epidermal barrier, which is one of the prerequisites for the colonization of bacteria and fungi on the affected skin. Purpose - to investigate the presence of Staphylococcus aureus and Malassezia species skin colonization in patients with atopic dermatitis. Materials and methods. Skin swabs were taken in 83 patients with atopic dermatitis and 70 healthy children to determine Staphylococcus aureus skin colonization. The level of Malassezia colonization in the samples was determined by polymerase chain reaction. Results. The affected skin in patients with atopic dermatitis was significantly more often colonized with Staphylococcus aureus than in healthy children (OR=3.974 (1.861-8.486)). SCORAD was significantly higher in Staphylococcus aureus carriers (p<0.05). In the subgroup of Staphylococcus aureus carriers, children were older and the duration of disease was longer (p<0.05). Malassezia restricta and Malassezia globosa were found in 11 patients with atopic dermatitis and 10 healthy children. The prevalence of Malassezia by species depended on sex and the presence of atopic dermatitis. Conclusions. Staphylococcus aureus skin colonization is significantly more prevalent in children with atopic dermatitis than in healthy people. Malassezia species are common on the skin of both patients with atopic dermatitis and healthy people, but the ratio of species may vary depending on the presence of disease. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author. Key words: Staphylococcus aureus, Malassezia, atopic dermatitis, children.

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The significance of Staphylococcus aureus skin colonization and the yeast Malassezia in children for the development of atopic dermatitis

Mozyrska¹

2022

MPU

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“…Atopic dermatitis (AD) is a chronic, relapsing eczema. Although AD occurs mainly in children, it greatly affects the life of the whole family [1,2].…”

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confidence: 99%

“…The Family Dermatology Life Quality Index (FDLQI) is a questionnaire designed for adult family members (aged 16 years and older) or caregivers of a child with any skin di-UDС 616.5-002. 2 DOI: https://doi.org/10.22141/2224-0551. 18.1.2023.1554 O. Mozyrska Bogomolets National Medical University, Kyiv, Ukraine…”

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confidence: 99%

Study of the impact of atopic dermatitis in children on the quality of life of families

Mozyrska

2023

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Background. Atopic dermatitis is a chronic, relapsing eczema. Although atopic dermatitis occurs mainly in children, it greatly affects the life of the whole family. The purpose was to assess the quality of life of the families of children with atopic dermatitis and to study the correlation between the severity of atopic dermatitis and the quality of life of family members according to the Family Dermatology Life Quality Index (FDLQI) questionnaire. Materials and methods. The study included 104 patients with atopic dermatitis aged 6 months to 17 years (median of 6 [3; 9] years) who were treated at the Allergy Department of the Kyiv City Children’s Clinical Hospital 2. Clinical parameters included age, sex of the patients, disease duration and severity of atopic dermatitis. The latter was assessed by the SCORing for Atopic Dermatitis (SCORAD) tool. Spearman’s rank correlation index was used for analysis of correlation between FDLQI and SCORAD indicators. Р < 0.05 was considered statistically significant. Results. The quality of life of the family of 104 children with atopic dermatitis was assessed using the FDLQI questionnaire. Four parents (3.8 %) reported no impact of the disease on the family’s quality of life, 65 (62.5 %) — a mild effect, 34 (32.7 %) — a moderate impact, parents of 1 patient (1.0 %) noted a very large effect. The average FDLQI was 6.4 ± 2.8. There was a correlation between the FDLQI and the SCORAD severity index (Ro = 0.714, p < 0.01). In the subgroup of children under 4 years of age, a strong correlation between the FDLQI and the SCORAD was found (Ro = 0.789, p < 0.01). Child’s age and disease duration were not associated with the quality of life score (Ro = –0.011, p > 0.05 and Ro = 0.076, p > 0.05, respectively). In the subgroup of children aged 4–17 years, a strong positive correlation of FDLQI and the SCORAD was also determined (Ro = 0.714, p < 0.01). The age of the children and the duration of the disease were not related to the quality of life score (Ro = –0.011, p > 0.05 and Ro = –0.027, p > 0.05, respectively), although in the subgroup of younger children (4–7 years) we noted a tendency towards a greater influence of the disease on the family’s quality of life. Conclusion. In this study, most parents of children with atopic dermatitis reported a mild to moderate impact of the disease on their quality of life. The FDLQI of family members correlated with the severity of atopic dermatitis.

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Îðèã³íàëüí³ äîñë³äaeåííÿ / Original Researches

ВступАтопічний дерматит (АД) є поширеним свербіжним захворюванням шкіри, що несе значний тягар для пацієнтів, їхніх сімей і суспільства [1]. АД уражає приблизно 20 % дітей і 1-10 % дорослих із зростаючою поширеністю в усьому світі [2]. Перебіг АД може бути тривалим, рецидивуючим і часто суттєво впливає на якість життя пацієнтів та їхніх родин [2].

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“…АД уражає приблизно 20 % дітей і 1-10 % дорослих із зростаючою поширеністю в усьому світі [2]. Перебіг АД може бути тривалим, рецидивуючим і часто суттєво впливає на якість життя пацієнтів та їхніх родин [2]. Вимірювання показників для оцінки АД зазвичай базуються на клінічних ознаках, оскільки на сьогодні небагато…”

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Clinical experience of using the Children’s Dermatology Life Quality Index in children with atopic dermatitis

Mozyrska

2023

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Background. Atopic dermatitis is a common pruritic skin disease that causes a significant burden on patients, their families, and society. The purpose of this work was to evaluate the quality of life of children with atopic dermatitis and to study the correlation between the severity of atopic dermatitis and the quality of life according to the Children’s Dermatology Life Quality Index (CDLQI). Materials and methods. Patients with atopic dermatitis (n = 71) aged 4–17 years from the allergy department of the Kyiv City Children’s Clinical Hospital No. 2 were included in the study. The severity of atopic dermatitis was assessed by the SCORing Atopic Dermatitis (SCORAD) tool, and the quality of life — by the CDLQI. Spearman’s rank correlation coefficient was used for correlation analysis of the CDLQI and the SCORAD indicators. Correlation was considered probable at p < 0.05. Results. Atopic dermatitis had a small effect on the quality of life in 25.4 % patients, a moderate effect — in 40.8 %, a very large effect — in 19.7 %, and in 12.7 % of patients, atopic dermatitis caused an extremely large effect on the quality of life. Spearman’s correlation coefficient of severity indicators on the SCORAD and the CDLQI was Ro = 0.932; a correlation was found at the significance level of p < 0.01. When evaluating correlation indicators in subgroups of children by degree of severity, a difference was found: in patients with mild atopic dermatitis, there was no correlation (Ro = 0, p > 0.05), in contrast to the group with moderate to severe (Ro = 0.625, p < 0.01) and severe atopic dermatitis (Ro = 0.688, p = 0.01). The quality of life indicator had a positive correlation with the age of patients and duration of the disease, which may be related to a more severe course and a greater social and psychological burden for older children. Conclusions. The Ukrainian version of CDLQI is a reliable tool for assessing the quality of life of paediatric patients with atopic dermatitis.

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Allergic and non-allergic skin diseases in children of Ukraine: a retrospective study of the prevalence and incidence over the past 24 years

Cited by 6 publications

References 0 publications

The significance of Staphylococcus aureus skin colonization and the yeast Malassezia in children for the development of atopic dermatitis

The significance of Staphylococcus aureus skin colonization and the yeast Malassezia in children for the development of atopic dermatitis

Study of the impact of atopic dermatitis in children on the quality of life of families

Clinical experience of using the Children’s Dermatology Life Quality Index in children with atopic dermatitis

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