Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates

Abstract

on behalf of the LISA study group Allergens and endotoxin on mothers9 mattresses and total immunoglobulin E in cord blood of neonates. J. Heinrich, G. Bolte, B.Hölscher, J. Douwes, I. Lehmann, B. Fahlbusch, W. Bischof, M. Weiss, M. Borte, H-E. Wichmann, on behalf of the LISA study group. #ERS Journals Ltd 2002. ABSTRACT: The current authors examined whether mite and cat allergen and bacterial endotoxin levels in dust of the mothers9 mattresses were associated with cord blood immunoglobulin (Ig)E (CB-IgE) levels in newborns.Data from 1,332 term and normal weight neonates, from an ongoing birth cohort study, Influences of life-style related factors on the immune system and the development of allergies in childhood (LISA), with complete information on exposure to biocontaminants in mattress dust and CB-IgE were analysed. (4th quartile) were chosen as cut-offs. Nonparametric smoothing (generalised additive models) showed statistically significant confounder-adjusted associations between elevated CB-IgE levels (o0.45 kU?L -1 ) and log-transformed exposures to cat (linear), mite (inverse u-shaped), and endotoxin (u-shaped).After adjustment for covariables, elevated CB-IgE levels (logistic regression using the 1st-4th quartiles of exposure) were positively associated with high cat-allergen exposure and medium exposure to mite allergen, but were inversely associated with exposure to endotoxin. The associations were similar, but somewhat weaker, when 0.35 kU?L -1 was used as cut-off. These results, showing an association between prenatal allergen and endotoxin exposures and immunoglobulin E production, suggest that the development of foetal immune responses may be affected.

Nonallergic respiratory morbidity improved along with a decline of traditional air pollution levels: a review

“…Within the LISA cohort study there was an association between prenatal endotoxin exposure and IgE production [29]. Additional support for the important role which endotoxin exposure might play comes from a cross-sectional study, which found an association between exposure to higher levels of house-dust endotoxin with lower prevalence of allergic sensitisation in children [30].…”

Variation of biocontaminant levels within and between homes — the AIRALLERG study

“…The AIRALLERG study was conducted in the framework of four ongoing birth cohort studies of similar design: PIAMA in the Netherlands (Brunekreef et al, 2002), BAMSE in Sweden (Wickman et al, 2002) and GINI (von Berg et al, 2003) and LISA (Heinrich et al, 2002) in Germany. The AIRALLERG study was designed to obtain environmental samples, including dust samples from mattresses and living room floors, in the homes of 180 sensitized and 180 nonsensitized children in each country.…”

Elevated Serum 25(OH)-Vitamin D Levels Are Negatively Correlated with Molar-Incisor Hypomineralization

“…At the 2-or 4-, 6-, and 10-y follow-ups, the children were clinically examined by a pediatrician, and the parents completed several age-related questionnaires regarding their children's medical, nutritional, behavioral and socioeconomic characteristics. Details concerning the study background, representative recruitment strategy, inclusion and exclusion criteria and protocols have been extensively described elsewhere (Heinrich et al 2002;Zutavern et al 2006, von Berg et al 2013. Almost 50% of subjects were lost to follow-up during the first 10 y due to various circumstances, including withdrawals, the inability to trace the participants, and waning interest.…”