Allergen sensitisation among chronic respiratory diseases in urban and rural areas of the south of Viet Nam

Chu, Ha Thi; Godin, Isabelle; Phương, Nguyễn Thanh; Nguyen, Lan Huu; Hiep, Tran Thi Mong; Michel, Olivier

doi:10.5588/ijtld.17.0069

Cited by 8 publications

(19 citation statements)

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“…The high prevalence of dust mite sensitization was consistent with previous studies in Vietnam [ 8 9 17 ]. Consistently with our data, a recent study in northern Vietnam reported a prevalence of sensitization by SPT of 23%, 13%, and 13% to Blo t, Der p, and cockroach, respectively, while sensitization was not associated with asthma [ 8 ].…”

Section: Discussionsupporting

confidence: 91%

“…Both active and suspected tuberculosis patients were excluded by routine chest X-ray and microbial sputum analysis. After obtained informed written consent, a lung function test (LFT) was measured [ 9 ] while blood sampling and SPT were performed after stopping antihistamines at least 5 days.…”

Section: Methodsmentioning

confidence: 99%

“…The main inclusion criteria were the presence of chronic respiratory symptoms lasting 3 months or more with a significant defect of lung function [ 9 ]. After measurement of the LFT before and after bronchodilator, asthma and COPD were defined as recommended by Global Initiative for Asthma and the Global Initiative for Chronic Obstructive Lung Disease guidelines [ 10 11 ].…”

Section: Methodsmentioning

confidence: 99%

“…Sensitization to house dust mite is the most frequent allergen among asthmatics in China [ 5 ], Thailand [ 6 ], Singapore [ 7 ], and the North of Vietnam [ 8 ]. In the South of Vietnam, we recently reported that, dust mites and cockroaches were the most frequent allergens sensitizers among patients with CRD and that the migration from rural to urban area increased the risk of dust mite sensitization [ 9 ]. However, due to the frequent consumption of shrimp, as well as the possible known cross-reactivity between dust mite and shrimp, its sensitization has to be considered in this population.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of skin prick test to screen dust mite sensitization in chronic respiratory diseases in Southern Vietnam

Chu¹,

Godin

Phương³

et al. 2018

Asia Pacific Allergy

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BackgroundIn the view of the epidemic growth of sensitization to indoor allergens in Southern Vietnam, there is a requirement to screen large population.ObjectiveTo evaluate skin prick tests (SPTs) as predictors of positive specific IgE (sIgE) to dust allergens, among patients with chronic respiratory diseases (CRDs).MethodsThe sensitization to Blomia tropicalis (Blo t), Dermatophagoides pteronissinus (Der p), and Blattella germanica allergens (Bla g) were evaluated among 610 CRD, both SPT (≥4 mm) and sIgE by immuno-CAP (≥0.7 kUA/L).ResultsBased on sIgE, 45%, 32%, and 33% of patients with CRD were sensitized to Blo t, Der p, and Bla g, respectively, compared to 19%, 18%, and 13% by SPT. The association between SPT and sIgE was statistically significant, though the Kappa factor was fair (i.e., 0.39 to 0.23). While the specificity of SPT to detect sensitization (compared to sIgE) was >90% among the whole population, the sensitivity was only 34%, 41%, and 24% for Bo t, Der p, and Bla g, suggesting that SPT was not enough sensitive to screen the indoor allergen sensitization. Though, among the <10 pack-year (PY) smokers, the sensitivity was 43% for Blo t, 52% for Der p, and 61% for Blo t and/or Der p, compared to 27%, 30%, and 35% among the ≥10 PY smokers. The sensitivity/specificity was not associated with the diagnosis of asthma compared to chronic obstructive pulmonary disease.ConclusionIn the present circumstance, SPT to dust mites allergens can be used to detect a sensitization among CRD population in Southern Vietnam.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of skin prick test to screen dust mite sensitization in chronic respiratory diseases in Southern Vietnam

Chu¹,

Godin

Phương³

et al. 2018

Asia Pacific Allergy

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“…The prevalence of allergic sensitization is rising in developing countries, 1 a phenomenon related to rapid urbanization 2 , 3 . In Vietnam, preliminary data suggest that an adult's migration from a rural to an urban area increases their risk of sensitization to mite allergens 4 that could contribute to a rapid increase of chronic respiratory diseases (CRD), which is one of the priorities of public health in Vietnam 5 . Compared to rural life, urban life is characterized by different outdoor and indoor pollution, disappearance of gut parasitosis, occupational factors, and food habits.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of rural life on mite sensitization disappears among urban migrants in the South of Vietnam

Chu

Tran

Doyen

et al. 2019

World Allergy Organization Journal

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BackgroundRapid urbanization combined with rural migration to urban areas in southern Vietnam could be risk factors for allergen sensitization, contributing to chronic respiratory diseases (CRD). We aimed to evaluate the prevalence of mite sensitization and its relation to house dust characteristics among rural and urban native and migrating populations with CRD.MethodsRural (n = 19) and urban (n = 46) dwellings were defined on the basis of a home typology. Controls were western Belgian houses (n = 14). Besides the house characteristics, both endotoxin and mite allergens were measured in the settled dusts. The sensitization to mite allergens was defined by positive skin prick test (SPT) and concentration of specific IgE (sIgE)≥ 0.7 U/mL. The prevalence of mite sensitization was evaluated among 610 patients with CRD and compared according to both their home types and places of birth and residences.ResultsThe concentration of endotoxin (but not mite allergen) was higher in rural compared to urban dusts (440 (95%CI: 314–566) versus 170 (95%CI: 115–226) EU/mg; p < 0.0001). The prevalence of positive sIgE to Der p1 and Der p2 was significantly lower in rural (9% and 5%) compared to urban (15% and 9%) population, consistent with the positive SPT to mite (14% and 21%, respectively). Among the urban migrants, the risk of mite sensitization (SPT) was higher compared to the rural natives (OR: 1.79 (1.02–3.15), p < 0.05) and not different to the urban ones (OR: 1.35 (0.82–2.23) p NS).ConclusionIn Vietnam, associated with higher endotoxin (but not allergen) dust concentrations, the risk of mite sensitization was lower in rural compared to the native urban population, but this protective effect could disappear among rural to urban migrants.

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Characteristics of allergen profile, sensitization patterns and Allergic Rhinitis in SouthEast Asia

Pham

Trinh

et al. 2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewTo highlight the characteristics of allergic rhinitis, local allergic rhinitis (LAR), and importance of allergens in Southeast Asian countries. Recent findingsThe Asia-Pacific region is very diverse with disparities in the epidemiological data between countries as well as in the unmet needs. The prevalence of allergic rhinitis has markedly increased in the past decades, with a high variation between countries, ranging from 4.5-80.3%. In terms of LAR, the reported prevalence in Southeast Asia is similar to that of other Asian countries (3.7-24.9%) but lower than that in western countries. House dust mites, cockroach, pollens, and molds are major allergens that are known triggers for of allergic rhinitis in this region, whereas the association with helminth infection requires further investigation.

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Allergen sensitisation among chronic respiratory diseases in urban and rural areas of the south of Viet Nam

Cited by 8 publications

References 0 publications

Evaluation of skin prick test to screen dust mite sensitization in chronic respiratory diseases in Southern Vietnam

Evaluation of skin prick test to screen dust mite sensitization in chronic respiratory diseases in Southern Vietnam

The protective effect of rural life on mite sensitization disappears among urban migrants in the South of Vietnam

Characteristics of allergen profile, sensitization patterns and Allergic Rhinitis in SouthEast Asia

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