Allergen Inactivation with Colloidal Silica

Abstract

We evaluated the allergen inactivating effect of colloidal silica by performing enzyme-liked immunosorbent assay (ELISA) whose wells were coated with 150 ng/mL of Japanese cedar pollen allergen (Cry j 1) or mite allergen (Der f 2). The allergens were almost 100% inactivated by 100 microg/mL of colloidal silica having a particle size 5 nm, and the inactivating effect was increased by aluminum binding to the surface of the colloidal silica. The results show that colloidal silica is a promising material for allergen inactivation. Since colloidal silica forms an insoluble nondispersive solid when dried, it is expected that airborne allergens can be reduced by binding them to colloidal silica.

Streamer discharge reduces pollen-induced inflammatory responses and injury in human airway epithelial cells

“…Several studies have reported methods of xenobiotic reduction using corona discharge, ions generated by plasma discharge, colloidal silica and hypochlorous acid. 31–35 Additionally, we suggest usefulness of streamer discharge as one of xenobiotic reduction technologies.…”