Allergen extract vs. component sensitization and airway inflammation, responsiveness and new‐onset respiratory disease

Abstract

Measurement of IgE sensitization to cat allergen components would seem to have a higher clinical value than extract-based measurement, as it related better to airway inflammation and responsiveness and had a higher prognostic value for the development of asthma and rhinitis over a 12-year period.

Sensitization to minor cat allergen components is associated with type‐2 biomarkers in young asthmatics

“…In a recent population‐based study, an independent association between IgE to Fel d 1 and both FeNO and airway responsiveness was seen, which might appear inconsistent with our findings. However, it is important to keep in mind the fundamental difference between a population‐based study that compares asthmatic and non‐asthmatic individuals, and our study, which investigates associations within a group of asthmatics.…”

Molecular Allergology between Precision Medicine and the Choosing Wisely initiative

“…The identification of IgE to profilins, polcalcins or other panallergens requires further workup checking IgE sensitizations to major, species-specific allergenic molecules before prescribing allergen immunotherapy (AIT) [18]. The study by Patelis et al [16] suggests that a CRD may refine a diagnosis based on allergen extracts and potentially increases the prognostic value for new onset of rhinitis and asthma.…”

“…Similarly, a 'negative' IgE-extract assay should always correspond to 'negative' outcomes in molecular-based IgE assays covering all the extract's components. Nevertheless, in this issue of Clinical and Experimental Allergy, Patelis et al [16] describe frequent conditions that serum IgE antibodies of allergic subjects recognize allergenic extracts of different sources (e.g. cat) but not their inherent components (e.g.…”

Multiplex component‐based allergen microarray in recent clinical studies

“…). Sensitization to both cat extract and any cat component but not sensitization to only extract was independently associated with more bronchial responsiveness and higher FeNO . Results from studies on the BAMSE cohort where the MEDALL customized version of the ISAC chip was used show that sensitization to Fel d 1 and Can f 1 in childhood and polysensitization to either cat or dog allergen molecules predict cat and dog allergy cross‐sectionally and longitudinally better than IgE to cat or dog extract .…”

“…A high level of sIgE to Bet v 1 or sensitization to many PR-10 proteins at 4 years of age was associated with increased incidence and persistence of AR up to age 16 [18]. IgE sensitization to cat and timothy components had higher clinical value as they associated independently with new onset of rhinitis and asthma, compared with traditional extract-based methods [53].…”