Allele frequencies of human platelet antigens in Banjar, Bugis, Champa, Jawa and Kelantan Malays in Peninsular Malaysia

Syafawati, Wan Ubaidillah Wan; Norhalifah, H. K.; Zulkafli, Zefarina; Zafarina, Zainuddin; Panneerchelvam, Sundararajulu; Nor, Norazmi Mohd; Chambers, Geoffrey K.; Edinur, Hisham Atan

doi:10.1111/tme.12220

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…Previously, we reported HPA allele frequency data for Malay subethnic groups [ 3 ] and Orang Asli [ 4 ] in Peninsular Malaysia. These earlier studies have provided a valuable preliminary source of genetic information for health assessments and population genetics.…”

mentioning

confidence: 99%

“…Our proposed study was reviewed and approved by the Human Ethical Committee, Universiti Sains Malaysia, Malaysia, and the Medical Research and Ethics Committee, Ministry of Health, Malaysia. The HPA typing and data analysis were performed as previously described by Wan Syafawati, et al [ 3 ] and Syafawati et al [ 4 ]. Briefly, isolated genomic DNA was amplified using polymerase chain reaction and sequence-specific primers (PCR-SSP) for HPA-1 to −6 and −15.…”

mentioning

confidence: 99%

“…The present and previously reported HPA datasets of various population groups in Peninsular Malaysia are shown in Table 1 [ 3 , 4 , 6 ]. These HPA datasets reveal that Malays and Chinese differ significantly ( P <0.05) from Indians ( Table 2 ).…”

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confidence: 99%

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Human Platelet Antigen Datasets for Malays, Chinese, and Indians in Peninsular Malaysia

et al. 2020

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confidence: 99%

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confidence: 99%

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Human Platelet Antigen Datasets for Malays, Chinese, and Indians in Peninsular Malaysia

et al. 2020

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“…In countries with multi-ethnic and admixed populations, the risk of HPA alloimmunization may be higher than that observed in more homogeneous populations [36,37]. This may occur due to a greater mismatch probability caused by the chance of ethnic differences between donors/patient (increasing the risk of alloimmunization by transfusion) and mothers/fathers (increasing the risk of NAIT).…”

Section: Discussionmentioning

confidence: 89%

Human Platelet Antigens in Brazilian Multiethnic Populations: Occurrence of Regional Variation and Frequency in a Large Urban Center (Belo Horizonte)

Silva-Malta

Oliveira

Barreiros

et al. 2018

Transfus Med Hemother

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Background: The frequency of human platelet antigens (HPA) varies according to ethnicity, which causes differences in the morbidity of alloimmune and autoimmune thrombocytopenic disorders in different populations. Studies on HPA frequencies in Brazil have reported differences among Brazilian populations produced by the diverse degrees of admixture throughout the country. Methods: In the present study, we investigated the variation of HPA distribution in Brazil, compared with worldwide populations, and describe the frequencies of HPA-1, -2, -3, -5, and -15 in a large urban center in Southern Brazil (Belo Horizonte) based on a sample of blood donors. Results: The principal component analysis and the dendrogram based on genetic distance revealed a clear relationship between Brazilian populations and the groups formed by European and African populations. The coefficients of variation for HPA allele frequencies suggest that Brazilian populations presented variations for HPA alleles comparable with the populations from continental groups. In Belo Horizonte, the allele a frequencies for HPA-1, -2, -3, -5 and -15 were 0.8575, 0.8400, 0.6225, 0.8525 and 0.5825 respectively. The genotypes with higher frequencies were a/a (72-74%), except for HPA-3 and -15, whose heterozygous a/b genotypes were shown to be more prevalent (43.5 and 44.5%, respectively). Conclusion: We confirmed the heterogeneity of HPA antigens in Brazilian populations, reinforcing the importance of HPA panels composed of regional blood donors, or a national panel that contemplates the specificities of the different regions of the country, in order to provide support in platelet transfusions and to minimize the risks associated with HPA alloimmunization. The evaluation of HPA data from Belo Horizonte represents the initial step toward the development of a genotyped platelet donor registry in order to treat HPA alloimmunized patients in this region.

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“…These systems include HLA, MICA, KIR, blood group, cytokine, HNA and HPA [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. These new datasets not only provide special insights into the ancestry of these people, but also is of significant value in health; as recently reviewed by [21][22].…”

Section: Ancestry and Healthmentioning

confidence: 99%

Genetic Ancestry and Health

Edinur¹,

Chamber²

2017

MOJI

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Information about genetic ancestry has a great value in health studies and other related areas of expertise such as anthropology, forensics and pharmacogenomics. In this review, we highlight several aspects of health that can be significantly improved by better understanding of genetic ancestry. These observations were made possible based on our own medical genetic research in Asia/Pacific populations (i.e. in particular regarding Maori and Orang Asli of New Zealand and Peninsular Malaysia, respectively). The major objectives of this programme of investigations has been to capture and understand genetic diversity in these populations and subsequently to make recommendations in order to maximise the health benefits of this type of population genetic research.

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Allele frequencies of human platelet antigens in Banjar, Bugis, Champa, Jawa and Kelantan Malays in Peninsular Malaysia

Cited by 9 publications

References 29 publications

Human Platelet Antigen Datasets for Malays, Chinese, and Indians in Peninsular Malaysia

Human Platelet Antigen Datasets for Malays, Chinese, and Indians in Peninsular Malaysia

Human Platelet Antigens in Brazilian Multiethnic Populations: Occurrence of Regional Variation and Frequency in a Large Urban Center (Belo Horizonte)

Genetic Ancestry and Health

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