Allantoin as a Vitamin

Gus'kov, E. P.; Прокофьев, В. Н.; Клецкий, М. Е.; Корниенко, И. В.; Gapurenko, Olga A.; Olekhnovich, L. P.; Chistyakov, V. A.; Шестопалов, А. В.; Сазыкина, М. А.; Markeev, A. V.; Шкурат, Т. П.; Malkhosyan, Sergei; Zhdanov, Yu. A.

doi:10.1023/b:dobi.0000046649.11374.8d

Cited by 22 publications

(21 citation statements)

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“…Allantoin was analysed in homogenates of chorion and placental villi. Similarly, in the 2nd trimester of pregnancy, Gus'kov et al [23] observed higher concentration of allantoin in normal pregnancy (5.01±0.34 µmol/g protein) than in women with late miscarriages (2.03±0.32 µmol/g protein; p < 0.001; N = 10). It was probably associated with the development of hypoxia in the placenta.…”

Section: Allantoinmentioning

confidence: 74%

“…Concentration of allantoin in plasma at rest was 11.9±2.6 µmol/l whereas after the exercise it was 2 times higher within 5 min, and remained high throughout recovery (p < 0.05) [26]. In another report, Gus'kov et al [23] describe statistically significant decrease in concentration of allantoin in placenta, in the first trimester of pregnancy, which was observed in women with non-progressive pregnancy (4.21±0.14 µmol/g protein; p < 0.001; N = 10), compared with women with physiological pregnancy (5.18±0.13 µmol/g protein; N = 35). On the other hand, early miscarriages were associated with increased concentration of allantoin in placenta (6.54±0.42 µmol/g protein; p < 0.05; N = 10).…”

Section: Allantoinmentioning

confidence: 88%

“…Allantoin production is independent of changes in the concentration of uric acid, and therefore, may be a good biomarker for assessing oxidative status in humans. It has been shown that the concentration of allantoin in the plasma increases in heavy smokers [20], type 2 diabetics [9,21], patients after chemotherapy [22], neonatal hypoxia during labour [23]. It was also found that the concentration of allantoin correlated with other markers of oxidative stress analyzed in the urine (e.g., F2-isoprostanes).…”

Section: Allantoinmentioning

confidence: 97%

“…It was probably associated with the development of hypoxia in the placenta. Moreover, it contributed to the activation of free radicals generation and non-enzymatic degradation of uric acid resulting in formation of allantoin [23].…”

Section: Allantoinmentioning

confidence: 99%

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Today’s oxidative stress markers

Czerska¹,

Mikołajewska²,

Zieliński³

et al. 2015

Med Pr

152

103

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Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop methods and find appropriate biomarkers that may be used to assess oxidative stress in vivo. It is significant because appropriate measurement of such stress is necessary in identifying its role in lifestyle-related diseases. Previously used markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS) or malondialdehyde (MDA), are progressively being supplemented by new ones, such as isoprostanes (IsoPs) and their metabolites or allantoin. This paper is focusing on the presentation of new ones, promising markers of oxidative stress (IsoPs, their metabolites and allantoin), taking into account the advantage of those markers over markers used previously. Med Pr 2015;66(3):393-405Key words: isoprostanes, oxidative stress, oxidative stress markers, allantoin, metabolites of isoprostanes StreszczenieStres oksydacyjny jest stanem braku równowagi między działaniem reaktywnych form tlenu (RFT) a działaniem antyoksydantów. Równowaga ta może być zakłócona w wyniku zwiększonego działania wolnych rodników lub spadku aktywności antyoksydacyjnej. Zaburzenia te mogą występować zarówno na poziomie komórkowym, jak i całego organizmu. Ponieważ stres oksydacyjny może być podłożem wielu zespołów chorobowych, niezwykle istotne jest znalezienie odpowiednich markerów, które mogą być wykorzystane do oceny jego poziomu in vivo. Stosowane od wielu lat markery -ocenę stężenia aldehyd dimalonowy (MDA) i substancji reagujących z kwasem tiobarbiturowym (thiobarbituric acid reactive substances -TBARS) -stopniowo uzupełnia się nowymi, takimi jak alantoina czy izoprostany (IzoP) wraz z ich metabolitami (IzoP-M). W niniejszej pracy skupiono się na zaprezentowaniu nowych, obiecujących markerów stresu oksydacyjnego (alantoina, IzoP, IzoP-M), ukazując korzyści wynikające z ich stosowania i prognozując dalsze kierunki badań nad ich zastosowaniem. Med. Pr. 2015;66(3):393-405 Słowa kluczowe: izoprostany, stres oksydacyjny, markery stresu oksydacyjnego, alantoina, metabolity izoprostanów Corresponding author / Autorka do korespondencji: Marta Czerska,

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Section: Allantoinmentioning

confidence: 74%

Section: Allantoinmentioning

confidence: 88%

Section: Allantoinmentioning

confidence: 97%

Section: Allantoinmentioning

confidence: 99%

See 2 more Smart Citations

Today’s oxidative stress markers

Czerska¹,

Mikołajewska²,

Zieliński³

et al. 2015

Med Pr

152

103

View full text Add to dashboard Cite

show abstract

“…[9,10] In aqueous solutions, the antioxidative properties of ALN and ascorbic acid were reported to be thermodynamically very close, allowing it to be regarded as a potential vitamin. [11,12] Electron spin resonance (ESR) spectrometry is a very important technique for the characterization of the paramagnetic species. [13] The technique is very sensitive, easy, nondestructive, and highly reliable and a useful technique for organic and inorganic materials.…”

Section: Introductionmentioning

confidence: 99%

Radiostability of Allantoin by Using Electron Spin Resonance Spectroscopy

Üstündağ

Korkmaz

2013

Spectroscopy Letters

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The radiosterilization potential and dosimetric feature of allantoin were investigated through the molecular degradations produced after ultraviolet and gamma irradiation using electron spin resonance, infrared, and ultraviolet spectroscopies and thermal measurement techniques (differential thermal analysis and the glass transition temperature). Although ultraviolet-irradiated allantoin presents no electron spin resonance signal, gamma irradiation exhibited an electron spin resonance signal of triplet appearance. Room temperature and high-temperature line intensity and spectrum area data and their variations with applied microwave power, storage time, annealing time, annealing temperature, and applied radiation dose were analyzed by assuming the production of two different types of radicals having different spectroscopic and decay characteristics. Based on its relatively stable nature toward gamma and ultraviolet radiations, it was concluded that allantoin itself and the products containing it can be sterilized by gamma and=or ultraviolet radiations without creating a great loss in its beneficial effects in the allowed radiosterilization dose limits.

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