Allantoin ameliorates chemically-induced pancreatic<i>β</i>-cell damage through activation of the imidazoline I3 receptors

Amitani, Marie; Cheng, Kai‐Chun; Asakawa, Akihiro; Amitani, Haruka; Kairupan, Timothy Sean; Sameshima, Nanami; Shimizu, Toshiaki; Hashiguchi, Teruto; Inui, Akio

doi:10.7717/peerj.1105

Cited by 7 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allantoin is a natural compound, which found in many plants, and its wound healing, anti-inflammatory, antidiabetic, and antihyperlipidemic effects have been demonstrated ( 19 20 21 22 26 ).…”

Section: Discussionmentioning

confidence: 99%

“…showed that allantoin increased the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), Sirt-1, and Nrf-1 in skeletal muscle cells ( 19 ). Previous studies have also indicated positive effects of allantoin on metabolic functions and streptozotocin-induced β-cells ( 20 ). We recently showed that allantoin improved NASH via downregulation of lipid metabolism-related genes such as SREBP1c, PPARα, and apolipoprotein B and attenuation of inflammation and apoptosis in methionine-choline deficient diet (MCD)-induced animals ( 21 ).…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis

Hamidizad

Moslehi

Rastegarpanah

2021

Research in Pharmaceutical Sciences

View full text Add to dashboard Cite

Background and purpose: Nonalcoholic steatohepatitis (NASH) is considered a common and serious liver disease, which develops into cirrhosis, fibrosis, and even hepatocellular carcinoma. Oxidative stress is identified as an important factor in the induction and promotion of NASH. Allantoin is a natural and safe compound and has notable effects on lipid metabolism, inflammation, and oxidative stress. Therefore, this study was aimed to assess the role of allantoin on the oxidative stress and SIRT1/Nrf2 pathway in a mouse model of NASH. Experimental approach: C57/BL6 male mice received saline and allantoin (saline as the control and allantoin as the positive control groups). NASH was induced by a methionine-choline deficient diet (MCD). In the NASH-allantoin (NASH-Alla) group, allantoin was injected for 4 weeks in the mice feeding on an MCD diet. Afterward, histopathological, serum, oxidative stress, and western blot evaluations were performed. Findings/Results: We found NASH provided hepatic lipid accumulation and inflammation. Superoxide dismutase (SOD) and glutathione (GSH) levels decreased, lipid peroxidation increased, and the expression of SIRT1 and Nrf2 downregulated. However, allantoin-treatment decreased serum cholesterol, ALT, and AST. Liver steatosis and inflammation were improved. Protein expression of SIRT1 and Nrf2 were upregulated and SOD, CAT, and GSH levels increased and lipid peroxidation decreased. Conclusion and implications: It seems that the antioxidant effects of allantoin might have resulted from the activation of SIRT1/Nrf2 pathway and increase of cellular antioxidant power.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis

Hamidizad

Moslehi

Rastegarpanah

2021

Research in Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

“…Besides, accumulated studies have revealed potential mechanisms of active compounds in YYT. The main active component of Dioscorea oppositifolia L. includes allantoin, which has been demonstrated with protective effects on pancreas β-cells in metabolic dysfunction model ( 12 ). Allantoin can also improve nonalcoholic steatohepatitis disease by activating the SIRT1/Nrf2 pathway, increasing the activities of antioxidant enzymes, and reducing lipid peroxidation ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats

Ma,

Sun,

Wang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

IntroductionYu–Ye Tang (YYT) is a classical formula widely used in treatment of type 2 diabetes mellitus (T2DM). However, the specific mechanism of YYT in treating T2DM is not clear.MethodsThe aim of this study was to investigate the therapeutic effect of YYT on T2DM by establishing a rat model of T2DM. The mechanism of action of YYT was also explored through investigating gut microbiota and serum metabolites.ResultsThe results indicated YYT had significant therapeutic effects on T2DM. Moreover, YYT could increase the abundance of Lactobacillus, Candidatus_Saccharimonas, UCG-005, Bacteroides and Blautia while decrease the abundance of and Allobaculum and Desulfovibrio in gut microbiota of T2DM rats. Nontargeted metabolomics analysis showed YYT treatment could regulate arachidonic acid metabolism, alanine, aspartate and glutamate metabolism, arginine and proline metabolism, glycerophospholipid metabolism, pentose and glucuronate interconversions, phenylalanine metabolism, steroid hormone biosynthesis, terpenoid backbone biosynthesis, tryptophan metabolism, and tyrosine metabolism in T2DM rats.DiscussionIn conclusion, our research showed that YYT has a wide range of therapeutic effects on T2DM rats, including antioxidative and anti-inflammatory effects. Furthermore, YYT corrected the altered gut microbiota and serum metabolites in T2DM rats. This study suggests that YYT may have a therapeutic impact on T2DM by regulating gut microbiota and modulating tryptophan and glycerophospholipid metabolism, which are potential key pathways in treating T2DM.

show abstract

“…Of particular interest in this region are the numerous extracts, which include allantoin, dioscorin, sapogenins, prosapogenin, gracillin, choline, L-arginine, polysaccharides and proteins. Several in vitro and in vivo studies have highlighted the antidiabetic action of a number of these extracts, including dioscorea ethanol extract (18) , total saponins (19)(20)(21)(22) allantoin (23,24) , water soluble polysaccharides (25) , DA-9801 (26) and diosgenin (27,28) . However, many of these studies have been conducted in animal models in which diabetes was induced by streptozotocin (STZ) (19)(20)(21)(22) or alloxan (18,25) .…”

mentioning

confidence: 99%

Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review

et al. 2021

View full text Add to dashboard Cite

Yam (Dioscorea spp.) and its associated extracts have been shown to possess a variety of biological activities and identified as beneficial in the control of glycaemia in patients with Type II Diabetes Mellitus (T2DM). The objective was to conduct a systematic search of the literature to investigate whether yam and its extract can improve glycaemia and whether consumption of yam could be beneficial for managing T2DM. Using the PRISMA guidelines and the PICO framework, three databases (PubMed, Scopus, and Web of Science) were searched using a key term strategy. Strict inclusion criteria were employed to identify all relevant and available studies. The quality of these studies was assessed using SYRCLE’s Risk of Bias tool. Ten studies were included; and all studies consisted of findings from rodent models of diabetes, including animals consuming high fat diets or genetic models of diabetes. All ten studies showed that consumption of yam and/or its extract (containing dioscin, dioscorin, diosgenin, DA-9801/02, or Chinese yam polysaccharides) improved glycaemia. These included improvements in fasting blood glucose and reductions in glucose and increase in insulin levels following a glucose tolerance test. Furthermore, significant changes in body weight and adiposity were observed in nine studies, these included improvements in lipid biomarkers in four and reductions in inflammatory markers in one. The current work indicates that the consumption of yam or its extracts can be beneficial for improving blood glucose however the molecular mechanism for these effects remain largely unknown. Future trials on human subjects are warranted.

show abstract

Allantoin ameliorates chemically-induced pancreaticβ-cell damage through activation of the imidazoline I3 receptors

Cited by 7 publications

References 37 publications

Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis

Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis

Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats

Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review

Contact Info

Product

Resources

About