All-sealed paper-based electrochemiluminescence platform for on-site determination of lead ions

Zhu, Lin; Lv, Xue Fei; Li, Zhenglin; Shi, Huihui; Zhang, Yan; Zhang, Lina; Yu, Jinghua

doi:10.1016/j.bios.2021.113524

Cited by 20 publications

(8 citation statements)

References 41 publications

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“…In the era of sustainability, the use of paper-based devices and smartphone-assisted biosensors has established one of the main pillars in the diagnostics field. The use of paper in their design allows for: i) the fabrication of the plastic-free devices; ii) the loading of the reagents onto the cellulose network delivering a reagent-free measure; iii) the customization of microfluidics with an equipment-free system exploiting the capillarity of the paper; iv) a treatment-free measurement thanks to the filter paper which can treat the sample during the analysis, v) the possibility to be incinerated, rendering more sustainable the management of waste in the case of infected samples ( Cate et al, 2015 ; Hamedi et al, 2016 ; Caratelli et al, 2020 ; Grant et al, 2020; Antiochia, 2021 , Zhu et al, 2021 , Zhang et al, 2020 , Noviana et al, 2021 ). At the same level, smartphone-assisted devices can boost the acquisition of the signal by smartphone, avoiding the use of a dedicated instrument.…”

Section: Introductionmentioning

confidence: 99%

Paper-based immunoassay based on 96-well wax-printed paper plate combined with magnetic beads and colorimetric smartphone-assisted measure for reliable detection of SARS-CoV-2 in saliva

Fabiani

Mazzaracchio

Moscone

et al. 2022

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 99%

Paper-based immunoassay based on 96-well wax-printed paper plate combined with magnetic beads and colorimetric smartphone-assisted measure for reliable detection of SARS-CoV-2 in saliva

Fabiani

Mazzaracchio

Moscone

et al. 2022

Biosensors and Bioelectronics

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“…More interestingly, the ECL zone and identify zone could be separated by the integrated BPE-ECL device, thus effectively preventing interference between each other. In addition, prior to constructing the BPE-ECL platform, the RGPEs were fabricated by the in situ growth method based on previous research 43 (details illustrated in the Supporting Information). As displayed in Figure 4A and the inset of Figure S3A, the AuNPs were compactly deposited on cellulose fibers, providing enough active sites for biological ligands immobilization.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Paper-Based Bipolar Electrode Electrochemiluminescence Platform Combined with Pencil-Drawing Trace for the Detection of M.SssI Methyltransferase

Zhu

et al. 2022

Anal. Chem.

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Herein, a hand-drawing paper-based bipolar electrode (BPE) electrochemiluminescence (ECL) platform for M.SssI methyltransferase (M.SssI MTase) assay was proposed via employing high electrocatalytic Pt@CeO2 as an ECL co-reaction accelerator and pencil-drawing graphite electric circuits as wires and electrodes. Notably, the introduction of pencil-drawing trace not only simplified the manufacturing process but also reduced the cost and saved fabricating time. Meanwhile, Pt@CeO2 with good electrocatalytic activity and satisfactory chemical stability was used at the anode of the closed BPE-ECL device to accelerate the oxidation rate of uric acid. Due to the balanced charges of the bipolar electrode, the ECL response of the MnS: CdS@ZnS/S2O8 2– system emitted on the cathode was enhanced. In situ growth of gold nanoparticles in the two electrode areas was convenient for DNA immobilization. With the above points in mind, the specific DNA double strands functionalized via Pt@CeO2 were employed to identify M.SssI MTase. The unmethylated DNA double strands were cut by HpaII endonuclease, resulting in the quenching of the ECL signal. Under the optimal conditions, sensitive detection of M.SssI MTase in a wide linear range of 0.01–100 U·mL–1 with a satisfactory detection limit of 0.008 U·mL–1 was realized. The reliable and versatile BPE-ECL tool for the determination of M.SssI MTase with easy-to-operate pencil-drawing traces and independent solution systems provides a new opportunity to develop paper-based devices applied in early disease diagnosis and pathogenesis research.

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“…Compared with chemiluminescence, this process can realize reasonable control of time and space. The use of ECL makes μPADs excellent for metal ion identification [ 82 ] and biomarker detection [ 83 ].…”

Section: μPads Based On Different Detection Methodsmentioning

confidence: 99%

Research Progress and Future Trends of Microfluidic Paper-Based Analytical Devices in In-Vitro Diagnosis

et al. 2022

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In vitro diagnosis (IVD) has become a hot topic in laboratory research and achievement transformation. However, due to the high cost, and time-consuming and complex operation of traditional technologies, some new technologies are being introduced into IVD, to solve the existing problems. As a result, IVD has begun to develop toward point-of-care testing (POCT), a subdivision field of IVD. The pandemic has made governments and health institutions realize the urgency of accelerating the development of POCT. Microfluidic paper-based analytical devices (μPADs), a low-cost, high-efficiency, and easy-to-operate detection platform, have played a significant role in advancing the development of IVD. μPADs are composed of paper as the core material, certain unique substances as reagents for processing the paper, and sensing devices, as auxiliary equipment. The published reviews on the same topic lack a comprehensive and systematic introduction to μPAD classification and research progress in IVD segmentation. In this paper, we first briefly introduce the origin of μPADs and their role in promoting IVD, in the introduction section. Then, processing and detection methods for μPADs are summarized, and the innovative achievements of μPADs in IVD are reviewed. Finally, we discuss and prospect the upgrade and improvement directions of μPADs, in terms of portability, sensitivity, and automation, to help researchers clarify the progress and overcome the difficulties in subsequent μPAD research.

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All-sealed paper-based electrochemiluminescence platform for on-site determination of lead ions

Cited by 20 publications

References 41 publications

Paper-based immunoassay based on 96-well wax-printed paper plate combined with magnetic beads and colorimetric smartphone-assisted measure for reliable detection of SARS-CoV-2 in saliva

Paper-based immunoassay based on 96-well wax-printed paper plate combined with magnetic beads and colorimetric smartphone-assisted measure for reliable detection of SARS-CoV-2 in saliva

Paper-Based Bipolar Electrode Electrochemiluminescence Platform Combined with Pencil-Drawing Trace for the Detection of M.SssI Methyltransferase

Research Progress and Future Trends of Microfluidic Paper-Based Analytical Devices in In-Vitro Diagnosis

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