2014
DOI: 10.1161/atvbaha.114.303458
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All Low-Density Lipoprotein Particles Are Not Created Equal

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Cited by 48 publications
(45 citation statements)
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“…Among modifiable CVD risk biomarkers, LDL-C and blood pressure have been the most strongly validated (110), and despite the complexity of individual risk assessment, they provide the major rationale for therapies aimed at reducing disease risk. As noted above, however, and described further below, reliance on identifying dietary macronutrient effects on LDL-C may obscure effects on LDL particles, especially sdLDL, that may have more direct and specific effects on the development and progression of CVD (93). …”
Section: Diet and Cardiovascular Disease Risk Factorsmentioning
confidence: 99%
“…Among modifiable CVD risk biomarkers, LDL-C and blood pressure have been the most strongly validated (110), and despite the complexity of individual risk assessment, they provide the major rationale for therapies aimed at reducing disease risk. As noted above, however, and described further below, reliance on identifying dietary macronutrient effects on LDL-C may obscure effects on LDL particles, especially sdLDL, that may have more direct and specific effects on the development and progression of CVD (93). …”
Section: Diet and Cardiovascular Disease Risk Factorsmentioning
confidence: 99%
“…Obesity is associated with increased risk of type 2 diabetes and cardiovascular disease (CVD) (2). One obesity-associated CVD risk factor is increased concentration of small dense low-density lipoprotein (LDL) particles (3). Type 2 diabetes and metabolic syndrome are known to be associated with higher incidence of the small dense LDL phenotype (4).…”
Section: Introductionmentioning
confidence: 99%
“…Variation in the concentration and size of lipoprotein particles (P), particularly LDL-P and HDL-P, has an impact on their function and relationship to atherosclerosis development [11,12]. Individuals who have normal concentrations of cholesterol that are distributed in small, dense LDL-P may be at increased risk of coronary heart disease [13].…”
Section: Introductionmentioning
confidence: 99%