All in the family: TGF-β family action in testis development

Itman, Catherine; Mendis, Sirisha; Barakat, Badia Maria; Loveland, Kate

doi:10.1530/rep.1.01075

Cited by 186 publications

(150 citation statements)

References 98 publications

(100 reference statements)

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“…33 This is supported by the finding that ActA can promote meiotic initiation in female germ cells in mice, and regulate spermatogenic cell and sertoli cell proliferation and differentiation, along with its functions in germ cell development in vivo and in vitro. 34,35 ActA is thus considered to be an important factor for PGCLC differentiation and development in vitro, as well as meiotic entry.…”

Section: Introductionmentioning

confidence: 99%

The crucial role of Activin A on the formation of primordial germ cell-like cells from skin-derived stem cells in vitro

Sun

et al. 2015

Cell Cycle

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Section: Introductionmentioning

confidence: 99%

The crucial role of Activin A on the formation of primordial germ cell-like cells from skin-derived stem cells in vitro

Sun

et al. 2015

Cell Cycle

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“…Many of these are involved in the reproductive function of both sexes (Itman et al 2006, Knight & Glister 2006. The AMH gene is located on chromosome 19 (Cohen-Haguenauer et al 1987, Cate et al 1990) and encodes a 140 kDa dimeric glycoprotein.…”

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian hormone and polycystic ovary syndrome: a mountain too high?

Pellatt¹,

Rice²,

Mason³

2010

Reproduction

190

112

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Anti-Mü llerian hormone (AMH) was initially thought to be produced solely by the foetal male during sexual differentiation to promote regression of the Mü llerian ducts. Over the last decade, however, a new and interesting role has emerged for AMH in the ovary. In human ovaries, AMH is produced by granulosa cells from 36 weeks of gestation until menopause, with the highest expression being in small antral follicles. AMH production gradually declines as follicles grow; once follicles reach a size at which they are dominant, it has largely disappeared. Its removal from these larger follicles appears to be an important requirement for dominant follicle selection and progression to ovulation as AMH has an inhibitory role in the ovary, reducing both primordial follicle initiation and follicle sensitivity to FSH by inhibition of aromatase. It is for this reason that AMH is a focus of interest in polycystic ovary syndrome (PCOS). Serum levels are doubled, and granulosa cell production is greatly increased. Interestingly, there appear to be two groups of women with PCOS who can be distinguished by their AMH level: one group consists of those who have high levels which do not reduce with treatment and who respond less well to induction of ovulation, and a second group consists of those in whom the level is less elevated and reduces on treatment and who seem to respond rather better. Understanding the reason for the raised AMH in PCOS may give clues as to the mechanism of anovulation. To conclude, AMH appears to have a major inhibitory role during folliculogenesis, which may contribute to anovulation in PCOS.

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“…Spermatogenesis can be theoretically separated into three phases: the mitotic, meiotic and spermiogenesis phases. For mice, the first wave of spermatogenesis takes about 35 days, during which the first generation of spermatogonia emerge at the 6th day post -partum (dpp), and the type B spermatogonia first appear at the 8th dpp, whereas the pre-leptotene spermatocytes emerge around the 10th dpp and the round spermatids at the 20th dpp [7].…”

Section: Introductionmentioning

confidence: 99%

Cyclin T2: A novel miR‐15a target gene involved in early spermatogenesis

Teng

Wang

et al. 2011

FEBS Letters

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Edited by Tamas DalmayKeywords: miR-15a Cyclin T2 Cell differentiation Spermatogenesis MicroRNA microarray a b s t r a c t MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression that play important roles in various biological processes. Spermatogenesis is a highly regulated process in which diploid spermatogonia eventually differentiate into haploid spermatozoa. In this study, we identified four differentially expressed miRNAs between two premeiotic male germ cells, made predictions about their putative targets, and confirmed cyclin T2 (Ccnt2) as a direct target of miR-15a. We also report that miR-15a inhibited muscle differentiation at least in part by targeting Ccnt2, which represents a novel interaction. Subsequently, miR-15a and Ccnt2 were profiled in developing mice testes to observe their inverse correlations in the postnatal 3-week period to understand their roles in spermatogenesis.

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All in the family: TGF-β family action in testis development

Cited by 186 publications

References 98 publications

The crucial role of Activin A on the formation of primordial germ cell-like cells from skin-derived stem cells in vitro

The crucial role of Activin A on the formation of primordial germ cell-like cells from skin-derived stem cells in vitro

Anti-Müllerian hormone and polycystic ovary syndrome: a mountain too high?

Cyclin T2: A novel miR‐15a target gene involved in early spermatogenesis

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