All‐Dry Synthesis and Coating of Methacrylic Acid Copolymers for Controlled Release

Lau, Kenneth K. S.; Gleason, Karen K.

doi:10.1002/mabi.200700017

Cited by 73 publications

(69 citation statements)

References 15 publications

(15 reference statements)

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“…The ability to dynamically alter surface properties is useful in a wide range of applications including biosensors, cell culture, microfluidics, and tissue engineering. The response of the surface can depend on externally applied stimuli, such light,150, 151, 152 temperature,87 or pH 153, 154, 155. The high degree of organic functional group retention by the iCVD synthesis method is essential for achieving the responsiveness.…”

Section: Responsive Icvd Surfaces and Devicesmentioning

confidence: 99%

“…pH‐responsive iCVD films have been incorporated into a variety of controlled release applications. Methacrylic acid (MAA)‐containing iCVD copolymers have been used as enteric coatings for pharmaceuticals 153. The benign reaction conditions inherent to the iCVD process make it an ideal method for coating thermally‐sensitive drugs.…”

Section: Responsive Icvd Surfaces and Devicesmentioning

confidence: 99%

“…The iCVD p(PFDA) has been widely studied either pure145, 168, 169 and copolymerized100, 153, 170 with other monomers. The side chains with eight perfluorinated carbons, so called “C8”, was completely retained during the polymerization169 giving interesting properties to the iCVD polymer such as hydrophobicity, oleophobicity, crystallinity.…”

Section: Fluoropolymersmentioning

confidence: 99%

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25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

et al. 2013

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Well-adhered, conformal, thin (<100 nm) coatings can easily be obtained by chemical vapor deposition (CVD) for a variety of technological applications. Room temperature modification with functional polymers can be achieved on virtually any substrate: organic, inorganic, rigid, flexible, planar, three-dimensional, dense, or porous. In CVD polymerization, the monomer(s) are delivered to the surface through the vapor phase and then undergo simultaneous polymerization and thin film formation. By eliminating the need to dissolve macromolecules, CVD enables insoluble polymers to be coated and prevents solvent damage to the substrate. CVD film growth proceeds from the substrate up, allowing for interfacial engineering, real-time monitoring, and thickness control. Initiated-CVD shows successful results in terms of rationally designed micro- and nanoengineered materials to control molecular interactions at material surfaces. The success of oxidative-CVD is mainly demonstrated for the deposition of organic conducting and semiconducting polymers.

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Section: Responsive Icvd Surfaces and Devicesmentioning

confidence: 99%

Section: Responsive Icvd Surfaces and Devicesmentioning

confidence: 99%

Section: Fluoropolymersmentioning

confidence: 99%

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25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

et al. 2013

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“…Some studies reported that low loading efficiency and burst release were observed in microcapsules, which indicates that it is challenging to regulate the release rate of G-Rg3 in order to maintain suitable drug concentration within a therapeutic window for enough exposure time [12]–[15]. The main formulation of G-Rg3 medications is a mixture suspension of G-Rg3 and physiological saline [16], [17].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Poly(L-Lactide) Fiber with Ginsenoside Rg3 for Inhibiting Scar Hyperplasia of Skin

Cui

Cheng

et al. 2013

PLoS ONE

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Hypertrophic scarring (HS) has been considered as a great concern for patients and a challenging problem for clinicians as it can be cosmetically disfiguring and functionally debilitating. In this study, Ginsenoside Rg3/Poly(l-lactide) (G-Rg3/PLLA) electrospun fibrous scaffolds covering on the full-thickness skin excisions location was designed to suppress the hypertrophic scar formation in vivo. SEM and XRD results indicated that the crystal G-Rg3 carried in PLLA electrospun fibers was in amorphous state, which facilitates the solubility of G-Rg3 in the PLLA electrospun fibrous scaffolds, and solubility of G-Rg3 in PBS is increased from 3.2 µg/ml for pure G-Rg3 powders to 19.4 µg/ml for incorporated in PLLA-10% fibers. The released G-Rg3 content in the physiological medium could be further altered from 324 to 3445 µg in a 40-day release period by adjusting the G-Rg3 incorporation amount in PLLA electrospun fibers. In vitro results demonstrated that electrospun G-Rg3/PLLA fibrous scaffold could significantly inhibit fibroblast cell growth and proliferation. In vivo results confirmed that the G-Rg3/PLLA electrospun fibrous scaffold showed significant improvements in terms of dermis layer thickness, fibroblast proliferation, collagen fibers and microvessels, revealing that the incorporation of the G-Rg3 in the fibers prevented the HS formation. The above results demonstrate the potential use of G-Rg3/PLLA electrospun fibrous scaffolds to rapidly minimize fibroblast growth and restore the structural and functional properties of wounded skin for patients with deep trauma, severe burn injury, and surgical incision.

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“…[24-27] We have already described in a previous paper the use of iCVD to produce 2-hydroxymethyl methacrylate (HEMA) based hydrogels with tunable swelling properties depending on the amount of incorporated crosslinking agent. [18] Also we have described the use of pentafluophenyl methacrylate (PFM) as reactive monomer for attaching biomolecules through nucleophilic substitution.…”

Section: Introductionmentioning

confidence: 99%

Functionalized, Swellable Hydrogel Layers as a Platform for Cell Studies

Marí-Buyé

OShaughnessy

Colominas

et al. 2009

Adv Funct Materials

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This paper reports the design, synthesis and characterization of thin films as a platform for studying the separate influences of physical and chemical cues of a matrix on the adhesion, growth and final phenotype of cells. Independent control of the physical and chemical properties of functionalized, swellable hydrogel thin films was achieved using initiated Chemical Vapor Deposition (iCVD). The systematic variation in crosslink density is demonstrated to control the swelling ability of the iCVD hydrogel films based on 2-hydroxyethyl methacrylate (HEMA). At the same time, the incorporation of controllable concentrations of the active ester pentafluorophenyl methacrylate (PFM) allows easy immobilization of aminated bioactive motifs, such as bioactive peptides. Initial cell culture results with Human Umbilical Vein Endothelial Cells (HUVEC) indicated that the strategy of using PFM to immobilize a cell-adhesion peptide motif onto the hydrogel layers promotes proper HUVEC growth and enhances their phenotype.

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All‐Dry Synthesis and Coating of Methacrylic Acid Copolymers for Controlled Release

Cited by 73 publications

References 15 publications

25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

Electrospun Poly(L-Lactide) Fiber with Ginsenoside Rg3 for Inhibiting Scar Hyperplasia of Skin

Functionalized, Swellable Hydrogel Layers as a Platform for Cell Studies

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