Alkaloids of the root-bark of Solanum paludosum Moric

Bhattacharyya, Jnanabrata; Basílio, Ionaldo José Lima Diniz; Morais, Liana Clébia Soares Lima de; Agra, Maria de Fátima; Majetich, George

doi:10.1016/j.bse.2009.02.005

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…FAT-SP, provided by our collaborator of phytochemistry (Bhattacharyya et al, 2009) was dissolved in distilled water to the concentration of (10 mg/mL) and stored at 0 • C. The stock solution was diluted in distilled water according to each experimental protocol.…”

Section: Drugsmentioning

confidence: 99%

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Vasorelaxant action of the total alkaloid fraction obtained from Solanum paludosum Moric. (Solanaceae) involves NO/cGMP/PKG pathway and potassium channels

Monteiro

Silva

Martins

et al. 2012

Journal of Ethnopharmacology

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Section: Drugsmentioning

confidence: 99%

“…A chemical study of the FAT-SP resulted in the identification (IR, 1 H and 13 C NMR with APT and DEPT) of the following compounds: N-hydroxysolasodine, leptinidine, tomatidenol and a new compound, putuline (see Bhattacharyya et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Vasorelaxant action of the total alkaloid fraction obtained from Solanum paludosum Moric. (Solanaceae) involves NO/cGMP/PKG pathway and potassium channels

Monteiro

Silva

Martins

et al. 2012

Journal of Ethnopharmacology

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“…Chemical studies resulted in the isolating of flavonoids (genkwanin, kumatakenin, ramnocitrin, protocatechuic acid, 3,4´,7,8-tetramethyl gossypetin ether, 3,3´,4´,7,8-pentamethyl gossypetin ether, retusin, 3-methyl quercetin ether) and an alkamide (N-p-coumaroyltyramine) from the aerial parts (Silva et al, 2002). The total alkaloid fraction from root bark showed the identification N-hydroxysolasodine, leptinidine, tomatidenol and putuline (Bhattacharyya et al, 2009). Previous result our showed SP-AcOEt presents endothelium-dependent and independent vasorelaxation.…”

Section: Introductionmentioning

confidence: 61%

Vasorelaxation endothelium-independent of the ethyl acetate phase from aerial parts of Solanum paludosum Moric. envolves channels-calcium L-type blockade

Silva¹,

Cavalcante

Silva

et al. 2021

RSD

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Previous results showed the ethyl acetate phase (SP-AcOEt), obtained from aerial parts of Solanum paludosum, relaxed the aorta isolated in the endothelium-dependent and -independent manner. The vasorelaxant effects of SP-AcOEt was not characterized on aorta rings endothelium-denuded, thus this work aimed to elucidate the mechanisms endothelium-independent vasorelaxation on rat isolated aorta. The aorta was isolated from Wistar rats and mounted in glass baths containing 6 mL of normal Krebs physiological solution with pH at 7.4. The preparation was maintained at 37ºC and bubbled continuously with a mixture of 95% O2 and 5% CO2. Aortic rings were maintained for 1 hour by a resting tension of 1g and next were contracted with phenylephrine after the sustained contraction ACh was added to access the integrity of the endothelium. SP-AcOEt relaxed pre-contracted aorta by KCl-30mM or -80mM in a similar manner, suggesting blockade CaV, but not channel-K+ participating. SP-AcOEt also inhibited the contraction induced by CaCl2 and relaxed pre-contracted aorta by (±)-BayK8644 (EC50 = 16.9±1.3 μg/mL), which confirms the involvement of L-type CaV blockade. SP-AcOEt presented vasorelaxation endothelium-independent that involves L-type CaV blockade.

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The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

103

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Alkaloids of the root-bark of Solanum paludosum Moric

Cited by 5 publications

References 8 publications

Vasorelaxant action of the total alkaloid fraction obtained from Solanum paludosum Moric. (Solanaceae) involves NO/cGMP/PKG pathway and potassium channels

Vasorelaxant action of the total alkaloid fraction obtained from Solanum paludosum Moric. (Solanaceae) involves NO/cGMP/PKG pathway and potassium channels

Vasorelaxation endothelium-independent of the ethyl acetate phase from aerial parts of Solanum paludosum Moric. envolves channels-calcium L-type blockade

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

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