Alkaloids of the menispermaceae

Thornber, C.W.

doi:10.1016/s0031-9422(00)86628-5

Cited by 58 publications

(36 citation statements)

References 134 publications

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“…This variation in activity may be due to the fact that 6 is composed of two coclaurinetype isoquinoline units linked by two C8-C12′ and C8′-C12 head-tail ether bonds, while in 4 and 5, the units are linked by C8-C12′ and C11-C7′ head-tail bonds. Previous studies with compounds such as isotetrandrine, pheanthine, cepha- ranthine and cycleanine highlight the important role played by stereochemistry in their activity (Thornber 1970). In our study, cycasin (1) was not active.…”

Section: Identification and Effects Of Mixtures And Isolated Compoundscontrasting

confidence: 52%

Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants

et al. 2011

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Extracts (34) from eight plant species of the Peruvian Amazonia currently used in traditional Peruvian medicine, mostly as antileishmanial remedies and also as painkiller, antiseptic, antipyretic, anti-inflamatory, antiflu, astringent, diuretic, antipoison, anticancerous, antiparasitic, insecticidal, or healing agents, have been tested for their antileishmanial, antitrypanosomal, and cytotoxic activity. Plant species were selected based on interviews conducted with residents of rural areas. The different plant parts were dried, powdered, and extracted by maceration with different solvents (hexane, chloroform, and 70% ethanol-water). These extracts were tested on promastigote forms of Leishmania infantum strain PB75, epimastigote forms of Trypanosoma cruzi strain Y, and the mammalian CHO cell line. Parasite viability and nonspecific cytotoxicity were analyzed by a modified MTT colorimetric assay method. The isolation and identification of pure compounds from selected extracts were performed by column chromatography, gas chromatography mass spectrometry (GC-MS; mixtures), spectroscopic techniques [MS, infrared (IR), ultraviolet (UV)], and mono and two-dimensional (1)H and (13)C nuclear magnetic resonance (NMR; COSY, HSQC, NOESY) experiments. Chondodendron tomentosum bark and Cedrela odorata were the most active extracts against Leishmania, while C. odorata and Aristoloquia pilosa were the most active against Trypanosoma, followed by Tabebuia serratifolia, Tradescantia zebrina, and Zamia ulei. Six compounds and two mixtures were isolated from Z. ulei [cycasin (1)], T. serratifolia {mixtures 1-2, and naphthoquinones 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione (2) and 2-(1-hydroxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione (3)}, and C. tomentosum [chondrocurine (4); (S,S')-12-O-methyl(+)-curine (5); and cycleanine (6)]. Four compounds and the two mixtures exhibited significant activity.

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Section: Identification and Effects Of Mixtures And Isolated Compoundscontrasting

confidence: 52%

Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants

et al. 2011

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“…The reaction centers from B.:.. viridis and Chromatium Fraction A were prepared fn the laboratory of J .. t1, Olson, using the methods of Thornber (1970Thornber ( , 1971. Key·steps in the isolation procedures involve the use of the deterge~t, sodium dodecyl sulfate (SDS), for solubilization, and hydroxylapatite chromatography.…”

Section: Methodsmentioning

confidence: 99%

“…(BCh 1) l molecules, which_ function to transfer lightexcitation energy to the reaction center. Several purified 0~ enri.ched re-action center preparations have been made from these bacteria (Reed and Clayton, 1968;Reed, 1969;Gingras and Jol-chine, 1969; Thornber et aL~ 1969; Thornber, 1970;Smith et al, 1972}. This is in (Fowler et .ll.…”

mentioning

confidence: 99%

Comparative study of the circular dichroism spectra of reaction centers from several photosynthetic bacteria

Philipson¹,

Sauer²

1973

Biochemistry

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“…This transfer would differ from induced host preference described by Bernays (1995) unless T. smilacina contains the same compounds found also in E. variegata. Thornber (1970) suggested that the utilisation of Erythrina spp. and Menispermaceae by O. fullonia was due to the similarity of their alkaloids, a suggestion also made by Cochereau (1977).…”

Section: Resultsmentioning

confidence: 99%

Survivorship of Australian Othreis fullonia on Erythrina variegata: hypotheses for development of host‐plant biotypes in the Pacific

Sands

Chan

1996

Entomologia Exp Applicata

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Alkaloids of the menispermaceae

Cited by 58 publications

References 134 publications

Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants

Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants

Comparative study of the circular dichroism spectra of reaction centers from several photosynthetic bacteria

Survivorship of Australian Othreis fullonia on Erythrina variegata: hypotheses for development of host‐plant biotypes in the Pacific

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