Alkaloids of Nelumbo lutea (Willd.) pers. (Nymphaeaceae)

Zelenski, Steven G.

doi:10.1002/jps.2600661132

Cited by 16 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent study, we found that Nelumbinis Semen (NS) had a distinct antidepressant effect in that it reduced the immobility time of rats in the forced swim (Kang et al 2005), reversing decreases of sucrose intake and serotonin (5-HT) 1A receptor binding in hippocampus (5-HT1A hetero-receptors) induced by CMS (Jang et al 2004). It is known that NS contains various alkaloids (Table 1) (Zelenski 1977;Wang et al 1991). Of these components, anonaine, asimilobine, isoquercitrin, hyperoside, lirinidine and nornuciferine have been most widely recognized as having antidepressant effects, as evaluated by neurotransmitter reuptake inhibition and the forced swimming test (Shoji et al 1987;Protais et al 1995;Hasrat et al 1997;Butterweck et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats

Kang

Pyun

Jang

et al. 2005

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Depression is associated with a dysfunctional serotonin system. Recently, several lines of evidence have suggested that a very important evoking factor in depression may be a serotonin deficit in the hippocampus. This study assessed the antidepression effects of Nelumbinis Semen (NS) through increasing serotonin concentrations under normal conditions and reversing a decrease in serotonin concentrations in rat hippo-campus with depression-like symptoms induced by chronic mild stress (CMS). Using an in-vivo microdialysis technique, the serotonin-enhancing effect of NS on rat hippocampus was investigated and its effects compared with those of two well-known antidepressants, Hypericum perforatum (St John's wort) and fluoxetine (Prozac). Rats were divided into five groups: saline-treated normal, without CMS; saline-treated stress control; NS-, St John's wort- and fluoxetine-treated rats under CMS for 8 weeks or no stress treatment. NS and fluoxetine significantly increased serotonin in normal conditions and reversed a CMS-induced decrease in serotonin release in the hippocampus (P<0.05 compared with normal group or control group under CMS). These results suggest that NS increases the serotonin levels normally decreased in depression, resulting in an enhancement of central serotonergic transmission and possible therapeutic action in depression. It is suggested that NS may present an antidepressant effect through enhancement of serotonin.

show abstract

Section: Discussionmentioning

confidence: 99%

Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats

Kang

Pyun

Jang

et al. 2005

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…-OCH 3 -OCH 3 -H -CH 3 -H -H -H -H Nelumbinis [78] Papaver armeniacum [94] P. fugax [94] P. tauricola [94] Nelumbo lutea (Wild.) -pers [75] [79] Annona squamosa [80] Nelumbo lutea (Wild.) -pers.…”

Section: Nuciferinementioning

confidence: 99%

“…pers. [75] Stephania kwangsiensis-H.S. Lo [17] O-Methylanolobine [1] - [72] Sparsiflorine [1] -OH [90] Variabiline [l] -OH…”

Section: Nuciferinementioning

confidence: 99%

Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Chen¹,

Gao²,

Liu³

et al. 2013

Asian J. Chem.

View full text Add to dashboard Cite

As a kind of common compositions in plants, there are many researches about alkaloids, which was firstly found from Nelumbo nucifera. Now more and more aporphine alkaloids appear during the experiments, which belong to isoquinoline type. There are number of pesticide effects about them, which have been revealed in recent years. So comprehensive information about the locality, formation and pesticide effects have been studied and presented in this research in different botany about aporphine alkaloids.

show abstract

“…It is known that Nelumbinis Semen contains various alkaloids [8]. Of the components of Nelumbinis Semen, anonaine, asimilobine, isoquercitrin, hyperoside, lirinidine and nornuciferine have been most recognized as having antidepressant effects, as evaluated by neurotransmitter reuptake inhibition and the forced swimming test [9].…”

Section: Discussionmentioning

confidence: 99%

Development of better antidepressant using Nelumbinis Semen in an animal model of depression

Shim

Bae

Kang

et al. 2006

International Congress Series

View full text Add to dashboard Cite

Alkaloids of Nelumbo lutea (Willd.) pers. (Nymphaeaceae)

Cited by 16 publications

References 3 publications

Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats

Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats

Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Development of better antidepressant using Nelumbinis Semen in an animal model of depression

Contact Info

Product

Resources

About