Alkaloids from Narcissus cv. Salome

Revised NMR data for Incartine: an Alkaloid from Galanthus elwesii

“…Hordenine (2) was identified by comparison of its spectroscopic data with those already reported [11]. Lycorine (3) [12], 8-O-demethylhomolycorine (4) [13] and hippeastrine (5) [14] were identified by direct comparison of their chromatographic and spectroscopic properties (TLC, CG-MS, MS, 1 H-NMR) with those of authentic samples obtained in our laboratory from other plant sources.…”

Phytochemical and Biological Investigation of Hymenocallis littoralisSalisb.

“…In fact, the EI-MS spectrum showed, beside the molecular ion at m/z 315, fragment peaks at m/z 190, 125, 124, and 96, in accord with the fragmentation mechanism characteristic for lycorenine-type alkaloids [10 -12]. From these data, the structure of 2 was identified as hippeastrine [10] [13] [14].…”

A New Amaryllidaceae Alkaloid from the Bulbs of Lycoris radiata

“…2 Actually, the bulbs of the species contains a lot of isoquinoline-based amine components, so called Amaryllidaceae alkaloids, which have been reported to possess a variety of pharmacological activities such as anti-cancer, 3 anti-viral, 4 anti-acetylcholinesterase 5 and anti-inflammatory 6 activities. Amaryllidaceae alkaloids are produced almost by plants of galanthus genus 7 in Amaryllidaceae and are classified with three distinct scaffolds, lycorine (3)(4)(5)(6)(7)(8)(9)14), haemanthamine (1-2, 10, 15-18) and galanthamine (11)(12)(13) series, which are classified depending on the pattern of oxidative phenolic coupling. For the purpose of searching for bioactive alkaloids from natural resources, extensive phytochemical investigation of the bulbs extract of L. radiata had undertaken and finally resulted in the isolation of a new amaryllidaceae alkaloid (1), together with seventeen related alkaloids (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

“…The chemical structures of isolated 1-18 ( Fig. 1) were established by spectroscopic analyses as 6-hydroxytazettine (1), tazettine (2), lycorine (3), 2-O-acetyllycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), hippeastrine (7), O-methyllycorenine (8), 2-α-hydroxy-6-O-methyloduline (9), haemanthidine (10), galantamine (11), dihydrogalantamine (12), lycoramine N-oxide (13), lycosinineB (14), ismine (15), trisphaeridine (16), 3-epimacronine (17), and 6-O-methylpretazettine (18), [8][9][10][11][12][13][14][15][16][17][18] respectively. In the present paper, we describe briefly the isolation and identification of a new Amaryllidaceae alkaloid (1), as well as the inhibitory activities of isolated alkaloids (1-18) on acetylcholinesterase, in vitro assay.…”

“…The other purified components (2-18) were identified by direct comparison of their spectral data with those in the literatures. [8][9][10][11][12][13][14][15][16][17][18] All isolated Amaryllidaceae alkaloids (1-18) were evaluated for the inhibitory effect on acetylcholinesterse (EC 3.1.1.7. electric eel) using acetylcholine as substrate in vitro 20 and it was observed that galantamine (11) and ismine (15) exhibited a significant inhibitory effect on the acetylcholinesterase with IC 50 values of 27.9 and 109.7 µM, when other isolated compounds showed poor inhibitions (IC 50 > 300 µM) on acetylcholinesterse, in vitro assay. …”