A New Amaryllidaceae Alkaloid from the Bulbs of Lycoris radiata

Lee, Ji Young; Cha, Mi-Ran; Lee, Ji Eun; Kim, Jinhee; Cho, Heeyeong; Park, Woo Kyu; Choi, Sang Un; Ryu, Shi Yong

doi:10.5012/bkcs.2014.35.12.3665

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…A new tazettine-type alkaloid 6-hydroxytazettine 7, together with seventeen known compounds tazettine, 3-epi-macronine, 6-O-methylpretazettine, haemanthidine, lycorine, 2-O-acetyllycorine, homolycorine, 9-O-demethylhomolycorine, hippeastrine, Omethyllycorenine, 2a-hydroxy-6-O-methyloduline, galanthamine, dihydrogalanthamine, lycoramine N-oxide, lycosinine B, ismine and trisphaeridine, was isolated from the bulbs extract of Korean L. radiata. 9 From the bulbs of L. radiata collected at Lanxi city of Zhejiang province, China, ten Amaryllidaceae alkaloids were isolated, and alkaloid oxovittatine 8 was identied as a new natural product, while others belong to known apohaemanthamine, 9-Odemethylhomolycorine N-oxide, incartine, ismine, 6-O-methylpretazettine, tazettine, ungeremine, homolycorine and O-methyllycorenine. 10 Alkaloids apohaemanthamine and 9-Odemethylhomolycorine N-oxide were isolated for the rst time from this genus.…”

Section: Occurrence Isolation and Identicationmentioning

confidence: 99%

Amaryllidaceae and Sceletium alkaloids

Jin

2016

Nat. Prod. Rep.

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Section: Occurrence Isolation and Identicationmentioning

confidence: 99%

Amaryllidaceae and Sceletium alkaloids

Jin

2016

Nat. Prod. Rep.

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ChemInform Abstract: A New Amaryllidaceae Alkaloid from the Bulbs of Lycoris radiata.

et al. 2015

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The Amaryllidaceae alkaloids: an untapped source of acetylcholinesterase inhibitors

et al. 2021

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The AChE inhibitory activity of alkaloid extracts and compounds has been in the focus of research on the plants of Amaryllidoideae subfamily since the approval of galanthamine in 2001 by FDA for treatment of mild to moderate Alzheimer's disease. A small fraction of the huge biodiversity of the plants producing Amaryllidaceae alkaloids has been studied as a source of AChE inhibitors. Less than 20% of the known Amaryllidaceae alkaloids have been tested in vitro for their ability to inhibit AChE. Galanthamine, lycorine and haemanthamine are scaffolds for semi-synthesis of potent AChE inhibitors. In the last years, galanthamine has been studied in silico for drug optimization and synthesis of potent dual-binding AChE inhibitors. In silico studies of other Amaryllidaceae alkaloids have also provoked the interest of researchers in the last years. The aim of this article is to provide a comprehensive review on studies of the AChE inhibitory activity of extracts and compounds from the plants of Amaryllidoideae subfamily covering the literature from the last two decades.

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A New Amaryllidaceae Alkaloid from the Bulbs of Lycoris radiata

Cited by 4 publications

References 13 publications

Amaryllidaceae and Sceletium alkaloids

Amaryllidaceae and Sceletium alkaloids

ChemInform Abstract: A New Amaryllidaceae Alkaloid from the Bulbs of Lycoris radiata.

The Amaryllidaceae alkaloids: an untapped source of acetylcholinesterase inhibitors

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