Alkaloids from Egyptian Papaver rhoeas

El-Masry, Sawsan; El–Ghaz;ooly, M.; Omar, Abdallah A.; Khafagy, S. M.; Phillipson, J. David

doi:10.1055/s-2007-971675

Cited by 26 publications

(19 citation statements)

References 8 publications

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“…N-methylasimilobine (IVJ colourless crystals from diethylether m.p. 195-196° [13]; UV X I?S' 231, 272, 314 nm [13]; MS, m/e (%), 281 (M4, 90), 280 (100), 266(67), 250(96), 128 (53), 223(60) [13]; TLC Rf values and colour reactions identical with reference alkaloid (Table I) [17]; 60 MHz 'H NMR spectrum obtained from CDCI3 solution same as thebaine minus -OCH3: 11 6.6(2H, q, J = 8Hz, C-I and C-2H), 5.6 and 5.9 (2H, d, J = 5Hz, C-7 and C-8H), 5.3 (IH, s, C-5H), 3.59 (3H, s, OMe), 2.47 (3H, s, NMe); TLC R, values and colour reactions identical with reference alkaloid (Table I).…”

Section: Sariyarmentioning

confidence: 99%

Alkaloids from Papaver cylindricum

Sarıyar¹

1982

Planta Med

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Section: Sariyarmentioning

confidence: 99%

Alkaloids from Papaver cylindricum

Sarıyar¹

1982

Planta Med

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“…It has been used in folk medicine for the treatment of inflammation, cough, diarrhea, respiratory problems, asthma, insomnia, and pain, and it can also be consumed as food [1][2][3][4][5]. Various phytochemical components can be found in corn poppy, such as alkaloids [2,[6][7][8], anthocyanins [9], flavonoids [10], and essential oils [11]. P. rhoeas can be cultivated in regions with a temperate climate.…”

Section: Introductionmentioning

confidence: 99%

Identification and metabolite profiling of alkaloids in aerial parts of Papaver rhoeas by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry

Lee

et al. 2018

J of Separation Science

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Papaver plants can produce diverse bioactive alkaloids. Papaver rhoeas Linnaeus (common poppy or corn poppy) is an annual flowering medicinal plant used for treating cough, sleep disorder, and as a sedative, pain reliever, and food. It contains various powerful alkaloids like rhoeadine, benzylisoquinoline, and proaporphine. To investigate and identify alkaloids in the aerial parts of P. rhoeas, samples were collected at different growth stages and analyzed using liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry. A liquid chromatography with mass spectrometry method was developed for the identification and metabolite profiling of alkaloids for P. rhoeas by comparing with Papaver somniferum. Eighteen alkaloids involved in benzylisoquinoline alkaloid biosynthesis were used to optimize the liquid chromatography gradient and mass spectrometry conditions. Fifty‐five alkaloids, including protoberberine, benzylisoquinoline, aporphine, benzophenanthridine, and rhoeadine‐type alkaloids, were identified authentically or tentatively by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry in samples taken during various growth stages. Rhoeadine alkaloids were observed only in P. rhoeas samples, and codeine and morphine were tentatively identified in P. somniferum. The liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry method can be a powerful tool for the identification of diverse metabolites in the genus Papaver. These results may help understand the biosynthesis of alkaloids in P. rhoeas and evaluate the quality of this plant for possible medicinal applications.

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“…This plant is claimed to be useful in the treatment of respiratory problems, asthma, cough, loss of voice, hay fever, insomnia, and intestinal and urinary irritations [3,4]. Previous phytochemical investigations on this plant have revealed the presence of mainly various alkaloids [5][6][7]. As part of our on-going screening of plant extracts for activities the purpose of this study was to investigate about the preliminary phytochemical screening of Papaver rhoeas L. and to evaluate analgesic and antiinflammatory activities of Papaver rhoeas L. aqueous extract in rodents.…”

Section: Introductionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Effects of Papaver Rhoeas L. A Traditional Medicinal Plant of Morocco

Hajjaj¹

2018

JONAM

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Papaver rhoeas L. is an annual herb belongs to the Papaveraceae family that has not been investigated yet in Morocco.The flowers of this plant have been used in treating mild pain caused by earache, toothache and neuralgia, and an infusion of the petals is traditionally taken for coughs, insomnia and poor digestion.In this study the toxicological effect of Papaver rhoeas L. aqueous extract (PRAE) was determined in mice. The toxicological results obtained indicated that 2000 mg/kg is LD50. Phytochemical screening of this plant revealed the presence of various bioactive secondary metabolites as tannins, saponins, terpenoids, flavonoids, and alkaloid. PRAE have been investigated for analgesic effects in acetic acid induced pain in mice and using tail flick in rats and for the antiinflammatory effects with the carrageen and experimental trauma-induced hind paw edema tests. Results demonstrated that Papaver rhoeas L. acts as a potent analgesic and anti-inflammatory agent in all tested models for analgesia and inflammation in Morocco.

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Alkaloids from Egyptian Papaver rhoeas

Abstract: N-methylasimilobine was isolated as the major alkaloid from an Egyptian sample of P. RHOEAS L. Other alkaloids isolated from the same plant material were stylopine, coptisine, isocorydine and rhoeadine. Chromatography indicated the presence of at least nine other minor alkaloids.

Cited by 26 publications

References 8 publications

Alkaloids from Papaver cylindricum

Alkaloids from Papaver cylindricum

Identification and metabolite profiling of alkaloids in aerial parts of Papaver rhoeas by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry

Analgesic and Anti-Inflammatory Effects of Papaver Rhoeas L. A Traditional Medicinal Plant of Morocco

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