Alkaloids from Corydalis bulbosa

Kiryakov, H. G.; Iskrenova, E.; Kuzmanov, B.; Evstatieva, L.

doi:10.1055/s-2007-971472

Cited by 18 publications

(14 citation statements)

References 3 publications

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“…The dried ethanol extract (30 g) corresponding to 3 kg dried whole plant material was chromatographed on an alumina column, as previously described (1). Seven major fractions were collected when the alkaloid mixture was eluted first with benzene and then with benzene containing increasing amounts of methanol.…”

Section: Resultsmentioning

confidence: 99%

“…Seven major fractions were collected when the alkaloid mixture was eluted first with benzene and then with benzene containing increasing amounts of methanol. This procedure yielded a series of known isoquinolme alkaloids which were isolated in our earlier investigation (1).…”

Section: Resultsmentioning

confidence: 99%

“…(Fumariaceae) are common herbs that grow wild and abundantly in local grass fields. These herbs have been used in traditional eastern medicine for varied purposes including treatment of diabetes, certain metabolic diseases, liver disorders and to purify blood (1,2,3). The present investigations were undertaken to study the effect of powdered Euphorbia prostrata and Fumariaparvifiora plants on blood glucose levels following oral administration to normoglycaemic and alloxantreated hyperglycaemic male albino rabbits.…”

Section: Resultsmentioning

confidence: 99%

“…As part of our programme of studying the flora of Bulgaria for its alkaloidal content we had occasion previously to investigate Corydalis bulbosa which is widespread in this country (1). Seventeen alkaloids, including the new aporphine base corydione (1,2) were isolated and characterized as a result of this investigation (1).…”

Section: Introductionmentioning

confidence: 99%

“…Seventeen alkaloids, including the new aporphine base corydione (1,2) were isolated and characterized as a result of this investigation (1).…”

Section: Introductionmentioning

confidence: 99%

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Minor Alkaloids ofCorydalis bulbosa, Structure of Bulbodione

Kiryakov¹,

Iskrenova²

1984

Planta Med

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As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated. These six alkaloids had not been detected in our initial study of the plant. The structure of buldodione was elucidated on the basis of spectral data and confirmed by synthesis of the alkaloid by means of Fremy's radical oxidation of bulbocapnine. The identification of the known alkaloids was obtained from their IR and (1)H-NMR spectral data and by direct comparison with authentic samples.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Seventeen alkaloids, including the new aporphine base corydione (1,2) were isolated and characterized as a result of this investigation (1).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Minor Alkaloids ofCorydalis bulbosa, Structure of Bulbodione

Kiryakov¹,

Iskrenova²

1984

Planta Med

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TM-1-1DP exerts protective effect against myocardial ischemia reperfusion injury via AKT-eNOS pathway

Lee

Chen

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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Coronary heart disease remains a leading cause of death in the world. The demand on targeting therapy to reduce myocardial ischemia/reperfusion (I/R) injury is still urgent. The pathogenesis of I/R-induced myocardial injury is complicated. Reactive oxygen species (ROS) generation and inflammatory response activation participate in the development of I/R injury. Cell death occurs and finally leads to myocardial infarction. A newly phenolic aporphine alkaloid derivative, TM-1-1DP, was synthesized in our team. We aimed to investigate the effect of novel compound on myocardial I/R injury. Rats were subjected to 1-h coronary artery occlusion and followed by 2-h reperfusion. Adult rat cardimoycyte was isolated for the cell study, and H2O2 was added into culture medium to induce ROS stress. As compared to the sham group, TM-1-1DP-treated rats had better cardiac performance in association with less infarct size and cardiac injury markers after myocardial I/R. The protective effect is associated with the inhibition of inflammatory response, cell death-related pathway (caspase-3 and TNF-α), and the activation of AKT-eNOS pathway. The finding was further coincided with the cell study. TM-1-1DP treatment significantly alleviated ROS production and improved cell viability in cardiomyocyte after H2O2 exposure. The action of TM-1-1DP is via a nitric oxide (NO)-dependent manner, since NOS inhibitor, L-NAME, abolished the protective effect. We provide a new insight into this therapeutic potential for phenolic aporphine alkaloid in myocardial I/R.

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