Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis

Deng, Aiping; Zhang, Yue; Zhou, Li; Kang, Chuan-Zhi; Lv, Chao-Gen; Kang, Liping; Nan, Tie-Gui; Zhan, Zhenlin; Guo, Lan-Ping; Huang, Luqi

doi:10.1016/j.phytochem.2020.112644

Cited by 20 publications

(6 citation statements)

References 150 publications

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“…) from near sea level to more than 6,000 meters in elevation, which is of great interest to the evolutionary biologists and ecologists (Ohara and Higashi, 1994;Ohkawara et al, 1997;Kudo et al, 2001;Ehlers and Olesen, 2004;Zhang et al, 2013;Niu et al, 2014Niu et al, , 2017Zhu et al, 2018). Additionally, a large number of species in Corydalis are medicinally valuable, and some have shown a great potential for anti-hepatitis, antitumor, treating cardiovascular diseases and releasing pains, such as the famous Chinese herb "Yuanhu" (C. yanhusuo; Luo et al, 1984;Editorial Board of Chinese Tibetan medicine, 1996;Kim et al, 1999;Chlebek et al, 2011;Chinese Pharmacopoeia Commission, 2015;Zhang B. et al, 2016;Alhassen et al, 2021;Deng et al, 2021). However, the classification of Corydalis is still controversial and notoriously difficult due, at least in part, to its intensive differentiation, complex morphological characters, and narrow distribution of enormously high elevation species.…”

Section: Introductionmentioning

confidence: 99%

New Insights Into the Backbone Phylogeny and Character Evolution of Corydalis (Papaveraceae) Based on Plastome Data

Wang

2022

Front. Plant Sci.

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A robust backbone phylogeny is fundamental for developing a stable classification and is instructive for further research. However, it was still not available for Corydalis DC., a species-rich (> 500 species), ecologically and medically important, but taxonomically notoriously difficult genus. Here, we constructed backbone phylogeny and estimated the divergence of Corydalis based on the plastome data from 39 Corydalis species (32 newly sequenced), which represent ca. 80% of sections and series across this genus. Our phylogenetic analyses recovered six fully supported main clades (I–VI) and provided full support for the majority of lineages within Corydalis. Section Archaeocapnos was unexpectedly turned out to be sister to the rest of the subg. Corydalis s. l. (clades IV–VI), thus treating as a distinct clade (clade III) to render all the main clades monophyletic. Additionally, some unusual plastome structural rearrangements were constantly detected within Corydalis and were proven to be lineage-specific in this study, which, in turn, provided further support to our phylogeny. A segment containing five genes (trnV-UAC–rbcL) in the plastome's LSC region was either normally located downstream of the ndhC gene in clade I species or translocated downstream of the atpH gene in clade II species or translocated to downstream of the trnK-UUU gene in clade III–VI species. The unique large inversion (ca. 50 kb) in the plastome LSC region of clade III species, representing an intermediate stage of the above translocation in clades IV–VI, firmly supported clade III as a distinct and early diverged clade within this large lineage (clades III–VI). Our phylogeny contradicted substantially with the morphology-based taxonomy, rejected the treatment of tuberous species as an independent evolutionary group, and proved that some commonly used diagnostic characters (e.g., root and rhizome) were results of convergent evolution, suggestive of unreliability in Corydalis. We dated the origin of crown Corydalis to the early Eocene (crown age 49.08 Ma) and revealed possible explosive radiation around 25 Ma, coinciding with the drastic uplift of the Qinghai-Tibetan Plateau in Oligocene and Miocene. This study provided the most reliable and robust backbone phylogeny of Corydalis to date and shed some new insights on the evolution of Corydalis.

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Section: Introductionmentioning

confidence: 99%

New Insights Into the Backbone Phylogeny and Character Evolution of Corydalis (Papaveraceae) Based on Plastome Data

Wang

2022

Front. Plant Sci.

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“…Accordingly, Corydalis components showed vascular relaxation effect [ 47 ] and neuroprotective effect [ 48 ] in vitro and/or ex vivo . Analgesia is one of the most important effects of Corydalis components, which are relatively nonaddictive and of low tolerance as compared to other analgesics [ 49 ]. Fifty-three out of 126 Papaveraceae species are used by China ethnic minorities against hepatobiliary diseases ( Table S2 ), and Corydalis and Meconopsis species are salient in this treatment [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Distribution of Therapeutic Efficacy of Ranunculales Plants Used by Ethnic Minorities on the Phylogenetic Tree of Chinese Species

Hao

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The medicinal properties of plants can be evolutionarily predicted by phylogeny-based methods, which, however, have not been used to explore the regularity of therapeutic effects of Chinese plants utilized by ethnic minorities. This study aims at exploring the distribution law of therapeutic efficacy of Ranunculales plants on the phylogenetic tree of Chinese species. We collected therapeutic efficacy data of 551 ethnomedicinal species belonging to five species-rich families of Ranunculales; these therapeutic data were divided into 15 categories according to the impacted tissues and organs. The phylogenetic tree of angiosperm species was used to analyze the phylogenetic signals of ethnomedicinal plants by calculating the net relatedness index (NRI) and nearest taxon index (NTI) in R language. The NRI results revealed a clustered structure for eight medicinal categories (poisoning/intoxication, circulatory, gastrointestinal, eyesight, oral, pediatric, skin, and urinary disorders) and overdispersion for the remaining seven (neurological, general, hepatobiliary, musculoskeletal, otolaryngologic, reproductive, and respiratory disorders), while the NTI metric identified the clustered structure for all. Statistically, NRI and NTI values were significant in 5 and 11 categories, respectively. It was found that Mahonia eurybracteata has therapeutic effects on all categories. iTOL was used to visualize the distribution of treatment efficacy on species phylogenetic trees. By figuring out the distribution of therapeutic effects of Ranunculales medicinal plants, the importance of phylogenetic methods in finding potential medicinal resources is highlighted; NRI, NTI, and similar indices can be calculated to help find taxonomic groups with medicinal efficacy based on the phylogenetic tree of flora in different geographic regions.

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“…Chronic atrophic gastritis is a precancerous stage that accelerates the progression from intestinal epithelial metaplasia to gastric cancer. Patients often experience bile reflux and bile-containing duodenal fluid in the stomach, which can seriously damage the gastric mucosa, which in turn can lead to gastric mucosal atrophy [ 10 , 11 ]. For this reason, effective clinical measures should be developed to reduce the inflammatory response of the gastric mucosa and prevent the deterioration of the disease.…”

Section: Discussionmentioning

confidence: 99%

A Web‐Based Pharmacological Approach to the Mechanism of Action of Rhizoma Phragmitis and Rhizoma Curcumae in the Treatment of Chronic Atrophic Gastritis

Zhi

Xie

Shao

et al. 2022

Contrast Media & Molecular Imaging

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Objective. To analyze and test the effect of Rhizoma phragmitis and Rhizoma curcumae on the network pharmacology of MAPK (mitogen-activated protein kinase) and TNF (tumor necrosis factor) signaling channels and inflammatory factor target gene regulation in successful modeling of chronic atrophic gastritis rats. Methods. Rats with chronic atrophic gastritis that were modeled successfully were randomly divided into control and study groups and were treated with conventional western medicine or Rhizoma phragmitis and Rhizoma curcumae, respectively. The pharmacological mechanism of action and efficacy were evaluated. Results. The treatment efficiency was 76.32% and 97.37% in the control and study group, respectively. After treatment, the serum tumor necrosis factor-α (TNF-α) and serum malondialdehyde (MDA) levels in the study group were lower than those in the control group and the serum epidermal growth factor (EGF) and superoxide dismutase (SOD) levels in the study group were higher than those in the control group (P < 0.05); the pain behavioral scores in the study group were lower than those in the control group, and the free acid quantity and total acid quantity in the study group were higher than those in the control group (P < 0.05); the serum MTL index in the study group was higher than that in the control group, and the serum gastrin (GAS) and pepsinogen I (PG I) indices in the study group were lower than those in the control group (P < 0.05); the number of 24-hour reflux in the study group was less than that in the control group (P < 0.05), and the longest reflux time in the study group was lower than that in the control group (P < 0.05). Conclusion. Based on the network pharmacological results, Rhizoma phragmitis and Rhizoma curcumae will modulate MAPK, TNF signaling circuits, and inflammatory factor target genes in the chronic atrophic gastritis rat model. This treatment protocol is efficient and beneficial to enhance the gastric function of the chronic atrophic gastritis rat model, while it can alleviate the inflammatory response and significantly reduce the number and duration of reflux, which is a safe and reliable treatment modality.

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Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis

Cited by 20 publications

References 150 publications

New Insights Into the Backbone Phylogeny and Character Evolution of Corydalis (Papaveraceae) Based on Plastome Data

New Insights Into the Backbone Phylogeny and Character Evolution of Corydalis (Papaveraceae) Based on Plastome Data

Distribution of Therapeutic Efficacy of Ranunculales Plants Used by Ethnic Minorities on the Phylogenetic Tree of Chinese Species

A Web‐Based Pharmacological Approach to the Mechanism of Action of Rhizoma Phragmitis and Rhizoma Curcumae in the Treatment of Chronic Atrophic Gastritis

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