Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity

Abstract

Four new alkaloids, ficuhismines A-D (1-4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1-2) or with a N-oxide motif (2-4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC 50 value of 0.52 ± 0.11 μM.

Ficus spp.: Phytochemical composition and medicinal potential

“…Ficuhismine B, an alkaloid isolated from the ethanol extract of branches and leaves, showed anti-inflammatory activity in vitro through the NF-κB pathway luciferase assay (Jia et al, 2020). The ethanolic and hydroethanolic extracts of the stem bark of F.…”

Crystallographic structure, antibacterial effect, and catalytic activities of fig extract mediated silver nanoparticles

“…Native to southwest Asia, Thailand, the Mediterranean, India, Australia, Burma, and the Andaman Islands. All parts of this plant (such as root, stem, bark, leaves, fruits, and latex) have long served in treating ulcers, diabetes, jaundice, and more [ 45 , 46 ]. Recent studies have highlighted its diverse therapeutic potential, including cardioprotective effects, vaginal diseases, wound healing, anti-diarrheal, astringent, emetic, hepatic protective, antipyretic, antitussive, anti-inflammatory, vulnerary, depurative, hemostatic, anemia, and antiulcer agents, yet gaps persist in comprehending its full electrical activity [ 47 , 48 ].…”

Chemical Constituents from the Stem Bark of Ficus thonningii and their Chemotaxonomic Significance

“…Phytochemical investigations on the genus Ficus have revealed flavonoids (especially isoflavones) [14][15][16][17][18] and terpenoids [19][20][21][22][23][24][25] as the major chemical constituents. Phytochemicals such as alkaloids [26][27][28], coumarins [29][30][31], and phenolic acids [32,33] have also been reported from various species of Ficus. However, the systematic phytochemical studies of F. thonningii from East Africa has hitherto not been reported.…”