Alkaloid and flavonoid rich fractions of fenugreek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects

Mandegary, Ali; Pournamdari, Mostafa; Sharififar, Fariba; Pournourmohammadi, Shirin; Fardiar, Reza; Shooli, Sedigheh

doi:10.1016/j.fct.2012.04.020

Cited by 94 publications

(46 citation statements)

References 16 publications

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“…The presence of phytoestrogen compounds like diosgenin in T. foenum-graecum may be responsible for this estrogenic effect (35). On the other hand, several studies have shown that T. foenum-graecum has antioxidative, anti-inflammatory, and immunomodulatory activities in male and female animals (16)(17)(18)(19). For example, it was demonstrated that diosgenin induces anti-inflammatory action in adipose tissue (36).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies also support anti-inflammatory and immunomodulatory activities of T. foenum-graecum in adult male animals (16)(17)(18). Recently, Sindhu et al (19) reported that mucilage extracted from ethanolic extract (EE) of T. foenum graecum has anti-inflammatory and antioxidative properties on adjuvant-induced arthritis in female rats.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Abedinzade¹,

Nasri²,

Omodi³

et al. 2015

Iran Red Crescent Med J

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Background: Several experimental and clinical studies support beneficial effects of Trigonella foenum-graecum (fenugreek) in the management of metabolic diseases and inflammatory disorders. Objectives: The purpose of this study was to examine the effect of T. foenum-graecum seed extract in reducing the metabolic and inflammatory alternations associated with menopause. Materials and Methods: In this experimental study, 49 rats were divided into seven groups: (I) sham-control, (II) ovariectomized-control, (III and IV) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum seed ethanolic extract, (V and VI) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum hexanic extract, (VII) ovariectomized-positive control treated with 10 µg/kg of estradiol. The extracts were injected intraperitoneally one day after ovariectomy and the treatments were lasted for 42 days. Results: Fasting blood glucose and body weight gain increased significantly in the ovariectomized-control group compared with that in the sham animals (P < 0.05). Administration of estradiol and T. foenum-graecum (50 and 150 mg/dL of hexanic extract and 150 mg/kg of ethanolic extract) significantly diminished the increase in glucose and body weight (P < 0.05). The serum level of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the ovariectomized control group was significantly higher than those in the sham animals (P < 0.05). Both hexanic and ethanolic extracts as well as estradiol were able to decrease level of these cytokines in the serum of ovariectomized rats (P < 0.05). Conclusions:The results of the present study show that administration of T. foenum-graecum corrects metabolic and inflammatory alterations associated with ovariectomy and has a potential for the management of menopause.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Abedinzade¹,

Nasri²,

Omodi³

et al. 2015

Iran Red Crescent Med J

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“…Among the listed medicinal herbs, Allium cepa, 41 Althaea officinalis, 42,43 Malva sylvestris, 44 Trigonella foenum-graecum, 45 and Vitex agnus-castus 46 contain flavonoid compounds that can be responsible for their anti-inflammatory effects. On the other hand, mucilaginous compounds of Althaea officinalis, 47 Malva sylvestris, 48 and Trigonella foenum-graecum, 49 in addition to anti-inflammatory activity, can be involved in the relief of symptoms through laxative effects.…”

Section: Discussionmentioning

confidence: 99%

Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)

Derakhshan

2016

J Evid Based Complementary Altern Med

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Most cases of chronic fissure do not respond to medical treatment. Razi and Ibn Sina were 2 of the best-known scientists of ancient Persia. The purpose of this study was to find out new scientific evidence in modern medicine about their recommendations, in order to find certain clues to conduct useful researches in the future. First, treatments of anal fissure mentioned by Razi and Ibn Sina were reviewed. Then, literature search was made in electronic databases including PubMed, Scopus, and Google Scholar. Management of anal fissure according to Razi's and Ibn Sina's practices is done based on 3 interventions: lifestyle modifications, drug treatments, and manual procedures. Almost all remedies suggested by Razi and Ibn Sina have shown their effects on fissure in ano via several mechanisms of action in many in vitro and in vivo studies; Still there is lack of human studies on the subject.

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“…), free amino acids (4-hydroxyisoleucine) and individual spirostanols and furastanols like vicenin-1, vitexin, diosgenin, gitogenin, yamogenin, etc. (Bhaskaran & Vishwaraman 2012;Mandegary et al 2012;Kandhare et al 2015b). All these ingredients have a broad spectrum of biological activities including antibacterial, anti-inflammatory, insulinotropic, antidiabetic, hypocholesterolemic, antifertility and anticancer activity (Valette et al 1984;Madar et al 1988;Al-Habori & Raman 1998;Aswar et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies

Kandhare

Bodhankar

Thakurdesai

2016

Pharmaceutical Biology

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Context: Vicenin-1, a flavonol glycoside, has potent platelet aggregation inhibition, antioxidant, radioprotectants and anti-inflammatory activities. Objective: To establish a rapid, simple, precise and sensitive high-performance liquid chromatography (HPLC) method for determination of vicenin-1 in rat plasma, and to investigate the pharmacokinetics, tissue distribution and excretion after a single 60 mg/kg oral dose in rats. Materials and methods: Vicenin-1 was extracted by solid-liquid extraction through Tulsicon V R ADS-400 (0.40-1.2 mm). Chromatographic separation was achieved by HPLC with a C 18 column with a mobile phase composed of water and acetonitrile (75:25 v/v) and a flow rate of 1 mL/min along with UV detection at 210 nm. Results: Good linearity of calibration curve was found between 10.5 and 100.5 lg/mL (R 2 ¼ 0.995) for plasma and tissue, whereas 2.5-500 lg/mL (R 2 ¼ 0.999) for the urine and stool samples. The extraction recoveries were 98.51-99.58% for vicenin-1 in plasma, whereas intra-day and inter-day precision were validated by relative standard deviation (%RSD), that came in the ranges of 1.16-1.79% and 1.28-1.73%, respectively. The pharmacokinetics results showed C max (7.039 lg/mL) and T max (2 h) after oral administration of vicenin-1. Tissue distribution study showed that the highest concentration of vicenin-1 was achieved in the liver followed by the lung. Approximately 24.2% of its administered dose was excreted via urinary excretion route. Conclusion: The first-pass metabolism, poor solubility and presence of reducing sugar moiety in vicenin-1 may decrease its bioavailability. The developed method is sensitive, specific and was successfully applied to the pharmacokinetics, tissue distribution and excretion studies of vicenin-1 in rats.ARTICLE HISTORY

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Alkaloid and flavonoid rich fractions of fenugreek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects

Cited by 94 publications

References 16 publications

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)

Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies

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