Alkaline Hydrogen Peroxide Solution is an Expectorant, Pyolytic, Mucolytic, Hemolytic, and Bleaching Drug for Treating Purulent Diseases, Hematomas and Bruising

Abstract

It has been established that warm alkaline solutions of hydrogen peroxide with local interaction with thick pus, mucus, sputum and blood have local pyolytic, mucolytic and hemolytic effects. It was found that the dissolving effect is associated with the alkaline properties of the drug, which are provided by sodium bicarbonate. Sodium bicarbonate provides the process of alkaline saponification of proteins and protein-lipid complexes. It is shown that hydrogen peroxide intensively decomposes into water and oxygen gas under the action of the catalase enzyme. In turn, catalase is always present in blood, mucus, sputum, pus, fibrous and serous fluid. At the same time, the released oxygen forms gas bubbles that literally tear apart biological masses during cold boiling and turn them into fluffy white foam. At the same time, the appearance of oxygen in an alkaline environment ensures the process of discoloration of biological pigments, such as hemoglobin and its color metabolites. The indicated pharmacological effect of a warm alkaline solution of hydrogen peroxide at local interaction is proposed to be used for the treatment of purulent diseases, thrombosis, bruising and hematomas. The technologies of using the drug for urgent restoration of breathing in obstructive purulent bronchitis, for urgent discoloration of the skin and nail plate with bruising and hematoma, as well as for urgent and safe peeling of a bloody bandage from a wound are listed.

Local Warm Alkaline Hydrogen Peroxide Solutions and Targeted Temperature Management Improve the Treatment of Chronic Wounds

“…It was found that additional dissolution of gases (carbon dioxide gas, oxygen gas, or inert gases) in WAHPSs under overpressure increased the efficiency of the pyolytic activity of WAHPss [20], [26]- [29]. Very soon, antiseptics with pyolytic activity were called "pyolytics" [19], and warm alkaline hydrogen peroxide solutions (WAHPSs) were proposed as a reference representative of this group [30], [31].…”

“…Moreover, this process is very intense and resembles a "cold boiling". The very intensive release of oxygen, which forms the process of cold boiling, "explodes" the purulent masses and turns them into oxygen foam [25]- [28], [30], [31].…”

Development of New Generation Drugs by Enriching Them with Gases

“…vascular catheter thrombosis, ischemia, hypoxia, and respiratory obstruction in COVID-19 [35]. In addition, new drugs allow to discolor the skin in the area of bruises, bloody areas of skin and other tissues, skin and nail plate in the area of the hematoma, to whiten teeth, dental and ceramic products [12,13,[14][15][16]31,32,33,34,35]. Therefore, it is necessary to continue research in this direction in order to get more information about the advantages and disadvantages of drugs enriched with gases both with the help of a WAHPS and/or with the help of overpressure of various gases.…”

Supplementing traditional drug formulation with the “needed” gases opens the way for the development of a new generation of drugs

“…«Лимфозаменитель для локального сохранения жизнеспособности органов и тканей при гипоксии и ишемии» (RU 2586292, 10.06.2016). Состав раствора: 0,01-0,03 % гидрокарбоната натрия и 0,88 % гидрокарбоната натрия [32].…”

“…«Энергетический напиток» (RU 2639493, 21.12.2017). Состав раствора: 7,0 % глюкозы, 0,7 % этилового спирта, 0,3-0,5 % перекиси водорода, лимонная кислота до pH 4,0 ± 0,5 и газ кислород в условиях избыточного давления 0,2 атм при температуре 8 °C [32].…”