Alkali treatment of dye-doped sol–gel glass films for rapid optical pH sensing

Ismail, F; Malins, Chris; Goddard, N J

doi:10.1039/b108370h

Cited by 47 publications

(47 citation statements)

References 16 publications

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“…10 seconds per step). This agrees with other experimental observations reported in literature (Ismail, 2002;Badini, 1995). Empirical quantification of this sensor behavior is shown in Fig.…”

Section: Resultssupporting

confidence: 83%

Plastic Optical Fiber pH Sensor Using a Sol-Gel Sensing Matrix

Rovati¹,

Fabbri²,

Ferrari³

et al. 2012

Fiber Optic Sensors

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Section: Resultssupporting

confidence: 83%

Plastic Optical Fiber pH Sensor Using a Sol-Gel Sensing Matrix

Rovati¹,

Fabbri²,

Ferrari³

et al. 2012

Fiber Optic Sensors

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“…However, the introduction and entrapment of a specific sensing material into it would then be the key issue [20]. Majorities of sol-gel based pH sensors are derived from tetraethoxysilane (TEOS) based aerogel but mostly suffer from long response time and limited long-term stability [21–23]. Later development focused on covalent immobilization of the indicator molecules [24–26] and surface hydrophobicity modification with organic end-groups, such as trimethylchlorosilane (TMCS), methyltriethoxysilane (MTES) or hexamethyldisiloxane (HMDSO), lead to appropriate replacement of –OH with –CH 3 [27, 28], and thus a better performance was achieved with improved reproducibility, shorter response time and enhanced chemical stability.…”

Section: Introductionmentioning

confidence: 99%

Reflection-mode micro-spherical fiber-optic probes for in vitro real-time and single-cell level pH sensing

Yang

Wang

Lan

et al. 2015

Sensors and Actuators B: Chemical

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pH sensing at the single-cell level without negatively affecting living cells is very important but still a remaining issue in the biomedical studies. A 70 μm reflection-mode fiber-optic micro-pH sensor was designed and fabricated by dip-coating thin layer of organically modified aerogel onto a tapered spherical probe head. A pH sensitive fluorescent dye 2′, 7′-Bis (2-carbonylethyl)-5(6)-carboxyfluorescein (BCECF) was employed and covalently bonded within the aerogel networks. By tuning the alkoxide mixing ratio and adjusting hexamethyldisilazane (HMDS) priming procedure, the sensor can be optimized to have high stability and pH sensing ability. The in vitro real-time sensing capability was then demonstrated in a simple spectroscopic way, and showed linear measurement responses with a pH resolution up to an average of 0.049 pH unit within a narrow, but biological meaningful pH range of 6.12–7.81. Its novel characterizations of high spatial resolution, reflection mode operation, fast response and high stability, great linear response within biological meaningful pH range and high pH resolutions, make this novel pH probe a very cost-effective tool for chemical/biological sensing, especially within the single cell level research field.

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“…Many pH dyes have been entrapped in sol-gels for the sensing of pH and acid-base gases including CO 2 and NH 3 [3][4][5][6][7][8][9][10][11][12][13][14]. In general, dye leaching was a major problem for pH sensors based on dyes entrapped in sol-gel.…”

Section: Introductionmentioning

confidence: 99%