Alkali ocular burns in Martinique (French West Indies)

Merle, H.; Donnio, A; Ayeboua, L.; Michel, F.; Thomas, Félix; Ketterlé, J.; Léonard, Christian; Josset, Patrice; Gérard, Max

doi:10.1016/j.burns.2004.09.001

Cited by 51 publications

(8 citation statements)

References 18 publications

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“…A recent study published by Merle et al 15 shows the usefulness of using Diphoterine even in cases of delayed rinsing, in the initial hours following an accident. The study compares, for equivalent grades of ocular burns, the differences which occur after rinsing with Diphoterine versus rinsing with saline solution before treatment of a base burn.…”

Section: Management Of Chemical Burnsmentioning

confidence: 96%

Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Mathieu¹,

Burgher²,

Blomet³

2007

J. Chem. Health Saf.

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Section: Management Of Chemical Burnsmentioning

confidence: 96%

Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Mathieu¹,

Burgher²,

Blomet³

2007

J. Chem. Health Saf.

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“… 6 , 7 Pre-clinical studies have demonstrated that Diphoterine was able to minimise pain and expedite wound healing by increasing the level of beta-endorphin and inhibiting the release of substance P. 13 In addition, a few clinical studies have highlighted that Diphoterine could reduce the severity of CEI when compared to normal saline irrigation. 10 , 11 Although the use of Diphoterine has been reported and adopted in certain parts of Europe, 10 , 11 , 14 only one case has been reported in the United Kingdom in relation to the efficacy of Diphoterine for ocular and cutaneous burn. 9 …”

Section: Discussionmentioning

confidence: 99%

“…Despite its ability to rapidly neutralise the pH and reduce tissue necrosis, 6 Diphoterine has not been widely adopted in the management of CEI in many countries, including the United Kingdom, primarily attributed to the limited clinical evidence available in the literature. 6 , 9 – 11 In view of the paucity of literature, our study aims to report the clinical outcomes and safety of Diphoterine in managing CEI in the United Kingdom.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes and safety of Diphoterine^® irrigation for chemical eye injury: A single-centre experience in the United Kingdom

et al. 2021

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Purpose: Diphoterine® is an amphoteric irrigating solution armed with rapid pH-neutralising action. It serves as an effective first-aid treatment for managing chemical burns, including chemical eye injury (CEI). However, its use is not widely adopted in current clinical practice, primarily attributed to limited clinical evidence. This study aims to highlight the experience in using Diphoterine for managing CEI in a UK tertiary referral centre. Methods: This retrospective case series included all patients who presented with CEI and treated with Diphoterine at the James Cook University Hospital, UK, between April 2018 and February 2020. Results: Seven patients (10 eyes) were included; the mean age was 28.2 ± 17.0 years (ranged, 3–70 years) and 85.7% were male. All patients presented with an alkaline injury with a mean presenting pH of 8.7 ± 0.7 and a median (±interquartile range [IQR]) corrected-distance visual acuity (CDVA) of 0.10 ± 0.28 logMAR. Based on Roper-Hall classification, 90% and 10% of the eyes were of grade-I and -IV CEI, respectively. All eyes received normal saline/water as the first irrigation fluid and Diphoterine as second irrigation fluid. The mean pH improved slightly after first irrigation (8.4 ± 0.7; p = 0.13) and significantly after second irrigation (7.6 ± 0.4; p = 0.001). The volume of irrigation used was significantly less for Diphoterine (520 ± 193 mL) than for normal saline/water (2700 ± 2451 mL; p = 0.016). At final follow-up (median = 5 days), the median CDVA remained stable at 0.10 ± 0.28 logMAR ( p = 0.60). One patient developed near-total limbal stem cell deficiency as a complication of grade-IV injury and was awaiting limbal stem cell transplantation at last follow-up. Conclusion: This study represents the first case series in the United Kingdom, reporting the use of Diphoterine in managing CEI. The rapid pH-neutralising action of Diphoterine, with less volume required, makes it an ideal initial treatment for efficiently managing adult and paediatric patients with CEI in clinics.

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“…30 However, in-hospital irrigation was delivered, on average, more than 40 minutes later in the group receiving normal saline. In addition, irrespective of injury severity, no significant differences were detected in vision or corneal opacification between the two groups.…”

Section: Management Of Immediate Phasementioning

confidence: 99%

Current and Upcoming Therapies for Ocular Surface Chemical Injuries

et al. 2017

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Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries.

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Alkali ocular burns in Martinique (French West Indies)

Cited by 51 publications

References 18 publications

Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Clinical outcomes and safety of Diphoterine^® irrigation for chemical eye injury: A single-centre experience in the United Kingdom

Current and Upcoming Therapies for Ocular Surface Chemical Injuries

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Alkali ocular burns in Martinique (French West Indies)

Cited by 51 publications

References 18 publications

Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Clinical outcomes and safety of Diphoterine® irrigation for chemical eye injury: A single-centre experience in the United Kingdom

Current and Upcoming Therapies for Ocular Surface Chemical Injuries

Contact Info

Product

Resources

About

Clinical outcomes and safety of Diphoterine^® irrigation for chemical eye injury: A single-centre experience in the United Kingdom