Alginate/starch blend fibers and their properties for drug controlled release

Wang, Qun; Hu, Xianwen; Du, Yumin; Kennedy, John F.

doi:10.1016/j.carbpol.2010.06.004

Cited by 141 publications

(52 citation statements)

References 19 publications

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“…The release rate and the cumulative percentage were found to be low when the concentration of drug was low thereby proving that at higher drug concentrations, more persistent release could be achieved with a higher cumulative release percentage. This result was in agreement with that observed by Wang et al, [35] for controlledrelease.…”

Section: Effect Of Loadingsupporting

confidence: 95%

Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery

Saravanabhavan

Dharmalingam

2012

J Mater Sci: Mater Med

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The recent advances in electrospinning have resulted in technologies facilitating easy drug entrapment, obtaining high surface area and thereby higher drug loading and release efficacy, burst control as well as the specific morphology which could be controlled according to the desired requirement. The present study focused on the fabrication of collagen/poly(N-isopropyl acrylamide)/chitosan complex with incorporated 5-fluorouracil, an anticancer drug by the method of electrospinning. The effect of chitosan on the fiber morphology and release kinetics was analyzed by varying its concentration. The release kinetics showed that the increase in chitosan concentration delayed the release of the drug from the fiber network. Nano hydroxyapatite was added to the fiber matrix in order to impart bioactivity, which was confirmed by studies in simulated body fluid. The addition of poly(N-isopropyl acrylamide) increased the blood compatibility of the prepared model. Thus, the model prepared to can find potential application in the field of cancer therapy as a drug-delivery agent in post-surgical treatment of cancer and as blood contacting biomaterial.

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Section: Effect Of Loadingsupporting

confidence: 95%

Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery

Saravanabhavan

Dharmalingam

2012

J Mater Sci: Mater Med

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“…Previous studies have demonstrated that intermolecular interactions and good molecular compatibility occur between starch and alginate (Wang et al, 2010). The ratio of alginate:starch was 1:0.3 (w/w), because larger proportions can damage the alginate-chitosan cross-linking by competing in the interpolymer interactions, leading to a failed or incomplete alginate-chitosan complex.…”

Section: Microparticle Productionmentioning

confidence: 99%

Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

Fujiwara

Campos

Costa

et al. 2013

Braz. J. Pharm. Sci.

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Stigmasterol -a plant sterol with several pharmacological activities -is susceptible to oxidation when exposed to air, a process enhanced by heat and humidity. In this context, microencapsulation is a way of preventing oxidation, allowing stigmasterol to be incorporated into various pharmaceutical forms while increasing its absorption. Microparticles were obtained using a blend of polymers of sodium alginate, starch and chitosan as the coating material through a one-stage process using the external gelation technique. Resultant microparticles were spherical, averaging 1.4 mm in size. Encapsulation efficiency was 90.42% and method yield 94.87%. The amount of stigmasterol in the oil recovered from microparticles was 9.97 mg/g. This technique proved feasible for the microencapsulation of stigmasterol.Uniterms: Stigmasterol/ microencapsulation. Microencapsulation. Sodium alginate/drugs coating. Chitosan/drugs coating. Starch/drugs coating. Natural polymers/drugs coating.O estigmasterol, um fitoesterol com diversas atividades farmacológicas, é suscetível à oxidação quando exposto ao ar, calor e umidade. Neste contexto, a microencapsulação é uma forma de proteção contra oxidação, permitindo a incorporação do estigmasterol em diversas formas farmacêuticas e aumentar sua absorção. As micropartículas foram obtidas por gelificação iônica externa, em uma etapa, utilizando como revestimento polímeros naturais de alginato de sódio, amido de milho e quitosana. As micropartículas apresentaram formato esférico com tamanho aproximado de 1,4 mm. O rendimento foi de 94,87% e a eficiência média de encapsulação de 90,42%. A quantidade de estigmasterol no óleo recuperado das micropartículas foi de 9,97 mg/g. O método mostrou-se viável para a microencapsulação do estigmasterol.Unitermos: Estigmasterol/microencapsulação. Microencapsulamento. Alginato de sódio/revestimento de fámacos. Quitosana/revestimento de fámacos. Amido/revestimento de fámacos. Polímeros naturais/ revestimento de fámacos.

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“…Sterilized PDA plates were prepared and a spherical ditch was made with a sterile borer in an aseptic area (30)(31)(32)(33)(34).…”

Section: In Vitro Antifungal Activitymentioning

confidence: 99%

Nanolipidgel for Enhanced Skin Deposition and Improved Antifungal Activity

Wavikar

Vavia

2012

AAPS PharmSciTech

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Abstract. The purpose of the research was to prepare and evaluate a topical nanolipidgel (NLH) of terbinafine hydrochloride (TRB), an antimycotic agent, for enhanced skin deposition and improved antifungal activity. Topical solid lipid nanoparticles (SLN) based nanolipidgel was formulated and evaluated. TRB-loaded SLNs were formulated by high-pressure homogenization technique. The stable TRB SLN dispersion was incorporated into a gel using 1% Carbopol 980 NF. Rheological evaluation and texture analysis of the TRB NLH was carried out. Skin permeation, skin deposition, antifungal activity, and occlusivity studies of the nanolipidgel formulation were carried out. The safety of the TRB NLH gel was evaluated using acute skin irritation test on New Zealand White rabbits. The SLN dispersion containing 10% of glyceryl monostearate, 3% of Tween 80, and 1% Plurol Oleique was the most stable. The optimized TRB SLN had a particle size and zeta potential value of 148.6 ± 0.305 nm and −20.4 ±1.2 mV, respectively. TRB NLH had excellent rheological and texture properties to facilitate its topical application. TRB NLH showed increased skin deposition of the drug over plain (3-fold) and marketed TRB formulation (2-fold). TRB NLH had significantly enhanced antifungal activity against Candida albicans. TRB NLH showed efficient occlusivity and was non-irritant to the rabbit skin with no signs of erythema or edema. Solid lipid nanoparticles-based topical nanolipidgel of terbinafine can be an efficient, industrially scalable, and cost-effective alternative to the existing conventional formulations.KEY WORDS: in vitro antifungal activity; rheological analysis of gel; solid lipid nanoparticles; terbinafine; texture analysis of gel.

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Alginate/starch blend fibers and their properties for drug controlled release

Cited by 141 publications

References 19 publications

Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery

Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery

Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

Nanolipidgel for Enhanced Skin Deposition and Improved Antifungal Activity

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