Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery

Abstract

The recent advances in electrospinning have resulted in technologies facilitating easy drug entrapment, obtaining high surface area and thereby higher drug loading and release efficacy, burst control as well as the specific morphology which could be controlled according to the desired requirement. The present study focused on the fabrication of collagen/poly(N-isopropyl acrylamide)/chitosan complex with incorporated 5-fluorouracil, an anticancer drug by the method of electrospinning. The effect of chitosan on the fiber morphology and release kinetics was analyzed by varying its concentration. The release kinetics showed that the increase in chitosan concentration delayed the release of the drug from the fiber network. Nano hydroxyapatite was added to the fiber matrix in order to impart bioactivity, which was confirmed by studies in simulated body fluid. The addition of poly(N-isopropyl acrylamide) increased the blood compatibility of the prepared model. Thus, the model prepared to can find potential application in the field of cancer therapy as a drug-delivery agent in post-surgical treatment of cancer and as blood contacting biomaterial.

Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications

“…It was observed from drug release kinetics that the drug was released in a sustained manner for a period of 180 h in PBS at pH 6.8. The initial phase or burst release was observed in all three cases the models that is in par with other research reports [26–29]. It has to be noted that the drug release in model 1 may be due to fickian diffusion and took a very long time owing to higher concentration & hydrophilic nature of PMMA that makes the drug release in a much-sustained fashion.…”

“…The release kinetics were fitted onto peppas model to further be confirmative about the type of release that might have occurred from composite models [29]. The model 1 had a value of n≥5 when fitted onto peppas model attributing to the fickian diffusion, the other two composite did not fit into any other models, which is out of the scope of our study.…”

[Retracted] An Investigation of Electrospun Clerodendrum phlomidis Leaves Extract Infused Polycaprolactone Nanofiber for In Vitro Biological Application

“…The nanofibers were deposited onto the aluminum-foil-wrapped grounded collector. To remove any remaining solvents from the nanofibers, they were processed in a vacuum dryer [ 30 – 32 ].…”

Bioactivity, hemocompatibility, and inflammatory response of calcium incorporated sulfonated polyether ether ketone on mouse-derived bone marrow cells

“…The procedure was described in one of our previous studies. In this study, the protocol described in our early study was followed [ 2 ], with the HITACHI S-3400N Scanning Electron Microscope (SEM) used to examine the immersed membrane for detailed fibrin formation. In addition, the weight of the blood clot formed against SPEEK and Ca-SPEEK was measured.…”

“…These include chitosan, polyacrylate, polysiloxanes, polysulfone, polyether ether ketone (PEEK), ultrahigh molecular weight polyethylene, polyurethane, polyamides, and polytetrafluoroethylene. PEEK is widely used for load-bearing orthopedic applications, as it is biocompatible and possesses good mechanical properties [1][2][3][4]. Many reports suggest using hydroxyapatite as a filler to enhance its bioactivity.…”