Alginate-pluronic topical gels loaded with thymol, norfloxacin and ZnO nanoparticles as potential wound dressings

Buyana, Buhle; Aderibigbe, Blessing Atim; Ndinteh, D. T.; Fonkui, Y.T.; Kumar, Pradeep

doi:10.1016/j.jddst.2020.101960

Cited by 30 publications

(13 citation statements)

References 34 publications

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“…The antibacterial activity of the NPs comes from the interaction with microbial cells, but at the same time the ZnO NPs can interact with human cells. In order to enhance the antibacterial activity of the packaging films, the ZnO can be loaded with other potent agents [ 48 , 49 , 50 ]. The use of a natural antimicrobial agent, like an essential oil, along with ZnO permits the use of low concentration for nanoparticles due to the synergic action.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Alginate Films with ZnO Nanoparticles and Citronella Essential Oil—A Novel Antimicrobial Structure

et al. 2021

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The petroleum-based materials could be replaced, at least partially, by biodegradable packaging. Adding antimicrobial activity to the new packaging materials can also help improve the shelf life of food and diminish the spoilage. The objective of this research was to obtain a novel antibacterial packaging, based on alginate as biodegradable polymer. The antibacterial activity was induced to the alginate films by adding various amounts of ZnO nanoparticles loaded with citronella (lemongrass) essential oil (CEO). The obtained films were characterized, and antibacterial activity was tested against two Gram-negative (Escherichia coli and Salmonella Typhi) and two Gram-positive (Bacillus cereus and Staphylococcus aureus) bacterial strains. The results suggest the existence of synergy between antibacterial activities of ZnO and CEO against all tested bacterial strains. The obtained films have a good antibacterial coverage, being efficient against several pathogens, the best results being obtained against Bacillus cereus. In addition, the films presented better UV light barrier properties and lower water vapor permeability (WVP) when compared with a simple alginate film. The preliminary tests indicate that the alginate films with ZnO nanoparticles and CEO can be used to successfully preserve the cheese. Therefore, our research evidences the feasibility of using alginate/ZnO/CEO films as antibacterial packaging for cheese in order to extend its shelf life.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Alginate Films with ZnO Nanoparticles and Citronella Essential Oil—A Novel Antimicrobial Structure

et al. 2021

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“…The presence of thymol can justify the findings as the main component of the Thymus vulgaris essential oil [ 77 ]. This compound has been proven effective in boosting the wound care process in various studies; Buyana et al showed the potential wound healing properties of topical gels loaded with thymol as dressings [ 78 ]. Pires et al [ 79 ] also tested the addition of thymol to poly(dimethylsiloxane) on chitosan-alginate film.…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Mekkaoui

Assaggaf

Qasem

et al. 2021

Foods

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Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits. Dressing mixtures of Thymus vulgaris honey with three essential oils (Origanum vulgare, Rosmarinus officinalis, and Thymus vulgaris) were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time. The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and Thymus vulgaris essential oil, which had wound closure rates of 85.21% and 82.14% in thermal- and chemical-induced burns, respectively, and showed the shortest healing time (14 days) in comparison to other groups. Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials.

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“…They are found in thyme oil extracted from Thymus vulgaris, a plant from the Lamiaceae family and a native plant of Southern Europe ranging from the Western Mediterranean to Southern Italy [14]. Many studies have shown that carvacrol and thymol have anti-inflammatory, antioxidant, skin fibroblast-stimulating, and antibiotic effects in the wound-healing process [138][139][140][141][142][143][144][145][146]. In this regard, Hamedi et al loaded a thyme oil nanoemulsion in chitosan alginate films (TM-PEC) at two different polymer ratios of polymers of 0.4 and 1 w/v% through a solvent evaporation technique [103].…”

Section: Essential Oils As Active Secondary Compounds In Wound Dressingsmentioning

confidence: 99%

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

Luca¹,

Pedram

Moeini

et al. 2021

Applied Sciences

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Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.

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Alginate-pluronic topical gels loaded with thymol, norfloxacin and ZnO nanoparticles as potential wound dressings

Cited by 30 publications

References 34 publications

Biodegradable Alginate Films with ZnO Nanoparticles and Citronella Essential Oil—A Novel Antimicrobial Structure

Biodegradable Alginate Films with ZnO Nanoparticles and Citronella Essential Oil—A Novel Antimicrobial Structure

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

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