Alginate nanoparticles protect ferrous from oxidation: Potential iron delivery system

Katuwavila, Nuwanthi P.; Perera, A. D. L. Chandani; Dahanayake, Damayanthi; Karunaratne, Veranja; Amaratunga, G.A.J.; Karunaratne, D. Nedra

doi:10.1016/j.ijpharm.2016.09.053

Cited by 72 publications

(42 citation statements)

References 26 publications

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“…Many polymers, which are biodegradable and biocompatible, have been utilized to prepare nanocarriers for drug delivery [11]. Among them, sodium alginate (NaAlg) broadly used in drug delivery application [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin – an antimicrobial drug

Güncüm

Işıklan

Anlaş

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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In this study, amoxicillin (AMO)-loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) nanoparticles were prepared as a polymer-based controlled release system. The physicochemical properties of the obtained nanoparticles were investigated by XRD, DSC/TGA, particle size analyses and zeta potential measurements. The average particle sizes were in the range from 336.3 ± 25.66 to 558.3 ± 31.39 nm with negative zeta potential values from -41.86 ± 0.55 to -47.3 ± 2.76 mV. The influences of PVA/NaAlg ratio, span 80 concentration, exposure time to glutaraldehyde (GA) and the drug/polymer ratio on AMO release profiles were evaluated. In vitro drug release studies showed a controlled and pH dependent AMO release with an initial burst effect. XRD patterns and DSC thermograms of AMO-loaded nanoparticles revealed that the drug in the nanoparticles was in amorphous form, which was more stable than the crystalline form. The antibacterial activity of the optimal formulation was also investigated. The minimum inhibitory concentration (MIC) values of this formulation had the comparable antibacterial activity with that of pure AMO. These results indicate that the developed nanoparticles could be a promising candidate drug delivery system for AMO.

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Section: Introductionmentioning

confidence: 99%

Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin – an antimicrobial drug

Güncüm

Işıklan

Anlaş

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…At pH > pKa, the carboxylate groups of alginates are ionized (Alg-COO − ) and electrostatically linked to calcium ions and cationic polymers [ 92 ]. Furthermore, the negatively charged carboxylate groups are predominant at weak acid medium around pH = 5 [ 85 ]. While, amino groups (NH 2 ) of chitosan are protonated (NH 3 + ) at pH below its pKa (6.5), it allows chitosan to coacervate with anionic polymers such as alginate [ 176 ].…”

Section: Factors Influencing Alginate Nanoparticles’ Characteristimentioning

confidence: 99%

Alginate Nanoformulation: Influence of Process and Selected Variables

2020

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Nanocarriers are defined as structures and devices that are constructed using nanomaterials which add functionality to the encapsulants. Being small in size and having a customized surface, improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create new biomedical applications owing to their stability, solubility, and bioavailability, as well as controlled release of drugs. The type and physiochemical as well as morphological attributes of nanoparticles influence their interaction with living cells and determine the route of administration, clearance, as well as related toxic effects. Over the past decades, biodegradable polymers such as polysaccharides have drowned a great deal of attention in pharmaceutical industry with respect to designing of drug delivery systems. On this note, biodegradable polymeric nanocarrier is deemed to control the release of the drug, stabilize labile molecules from degradation and site-specific drug targeting, with the main aim of reducing the dosing frequency and prolonging the therapeutic outcomes. Thus, it is essential to select the appropriate biopolymer material, e.g., sodium alginate to formulate nanoparticles for controlled drug delivery. Alginate has attracted considerable interest in pharmaceutical and biomedical applications as a matrix material of nanocarriers due to its inherent biological properties, including good biocompatibility and biodegradability. Various techniques have been adopted to synthesize alginate nanoparticles in order to introduce more rational, coherent, efficient and cost-effective properties. This review highlights the most used and recent manufacturing techniques of alginate-based nanoparticulate delivery system, including emulsification/gelation complexation, layer-by-layer, spray drying, electrospray and electrospinning methods. Besides, the effects of the main processing and formulation parameters on alginate nanoparticles are also summarized.

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“…Hixson-Crowell, and Korsemeyer-Peppas. [39][40][41] The model that exhibited the adjusted R 2 closest to unity (highest R 2 value) was selected as the best fit. The functions of the models with minor modifications are given as follows:…”

Section: X-ray Powder Diffraction (Xrd)mentioning

confidence: 99%

“…Korsmeyer-Peppas model proposed a semi-empirical design in which the drug release is proportional to the sum of two different powers of time which account for the pure diffusivity contribution. 39 In this kinetic model, the release exponent "n" is an important indicator of the mechanism of the drug release from the nanocomposites. For spherical particles, n ≤ 0.43 indicates a Fickian diffusion, while 0.43< n <0.85, indicates a non-Fickian release (an anomalous transport behavior), and n ≥ 0.85 represent Case II transport mechanism.…”

Section: Qualitative Identification Of the Nanocomposites A Simple Cmentioning

confidence: 99%

Novel Flaxseed Gum Nanocomposites Are Slow Release Iron Supplements

Liang

Huang

Shim

et al. 2018

J. Agric. Food Chem.

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Nanocomposites, based on iron salts and soluble flaxseed gum (FG), were prepared as potential treatments of iron deficiency anemia (IDA). FG was extracted, characterized, and formulated into iron-loading nanocomposites via ion-exchange against FeCl, Fe(SO), FeCl, and FeSO·7HO. FG-iron nanocomposites preparation condition was optimized, and physicochemical properties of the nanocomposites were investigated. In vitro release kinetics of iron in simulated gastric fluid (SGF) was also evaluated. FG heteropolysaccharide, consisting of rhamnose (33.73%), arabinose (24.35%), xylose (14.23%), glucose (4.54%), and galactose (23.15%) monosaccharides, linked together via varieties of glycosidic bonds, was a good recipient for both ferric and ferrous irons under screened conditions (i.e., 80 °C, 2 h, I/G = 1:2). Iron loaded contents in the nanocomposites prepared from FG-FeCl, FG-Fe(SO), FG-FeCl, and FG-FeSO·7HO were 25.51%, 10.36%, 5.83%, and 22.83%, respectively. Iron in these nanocomposites was mostly in a bound state, especially in FG-FeCl, due to chelation forming bonds between iron and polysaccharide hydroxyl or carboxyl groups and formed stable polysaccharide-iron crystal network structures. Free iron ions were effectively removed by ethanol treatments. Because of chelation, the nanocomposites delayed iron release in SGF and the release kinetics were consistent with Korsmeyer-Peppas model. This indicates that such complexes might reduce side effects of free iron in human stomach. Altogether, this study indicates that these synthetic FG-iron nanocomposites might be developed as novel iron supplements for iron deficiency, in which FG-FeCl is considered as the best option.

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Alginate nanoparticles protect ferrous from oxidation: Potential iron delivery system

Cited by 72 publications

References 26 publications

Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin – an antimicrobial drug

Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin – an antimicrobial drug

Alginate Nanoformulation: Influence of Process and Selected Variables

Novel Flaxseed Gum Nanocomposites Are Slow Release Iron Supplements

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